2022
Marx, Sebastian; Baluschev, Stanislav; Sickenberger, Wolfgang
Effect of phospholipid-containing eye drops on the dewetting behaviour of soft contact lenses Journal Article
In: Optometry and Contact Lenses, iss. 1, pp. 133-140, 2022.
@article{Marx2022b,
title = {Effect of phospholipid-containing eye drops on the dewetting behaviour of soft contact lenses},
author = {Sebastian Marx and Stanislav Baluschev and Wolfgang Sickenberger },
doi = {doi.org/10.54352/dozv.ILCA8295},
year = {2022},
date = {2022-05-30},
urldate = {2022-05-30},
journal = {Optometry and Contact Lenses},
issue = {1},
pages = {133-140},
abstract = {Abstract
Purpose: The primary objective of the study was to determine differences between in vitro surface de-wetting of soft contact lens (SCL) materials out of saline solution, before and after treatment with phospholipid containing rewetting drops.
Method and Materials: Fifteen lenses of different SCL material classes according to ISO18369 were tested (polymacon, nelfilcon A,
ocufilcon D, balafilcon A, somofilcon A, lotrafilcon B). The lenses were rinsed and stored in saline solution to minimize the effect of the original blister solution. A de-wetting video was captured for every lens using the Keratograph 5M. Afterwards all lenses were soaked in phospholipid containing rewetting solution for 25 hours. The lenses were gently agitated by an orbital shaker with a frequency 0.25 Hz, tilting up to 15°. After treatment, all lenses were equilibrated again in saline solution for at least 30 minutes. De-wetting videos were captured again. In vitro “Non-Invasive Keratograph Dry Up Time“ (NIK-DUT) was assessed for a measurement time of 180 s. The results were expressed by the Area under Curve (AUC) as well as clinical relevant time point to reach 4.82 mm de-wetting.
Results: The AUC results before and after treatment with phospholipid containing rewetting solution were: polymacon 4870.9 ± 942.7 and 6214.1 ± 932.1, nelfilcon A 4688.0 ± 1065.1 and 6959.8 ± 1081.8, ocufilcon D 3612.6 ± 875.5 and 7042.0 ± 714.3, balafilcon A 4170.4 ± 927.2 and 7385.6 ± 879.8, somofilcon A 4284.50 ± 833.8 and 6762.2 ± 1380.2 and lotrafilcon B, comfilcon A 4973.3 ± 1249.3 and 7415.7 ± 994.8. All differences were statistically significant at a significance level of 0.05 with P<0.001 (Wilcoxon rank sum test). The mean time to reach 4.82 mm2 de-wetting was 19 s.
Conclusions: The used phospholipid containing solution did interact with all soft contact lens materials and lead to accelerated in vitro de-wetting. As the de-wetting area of 4.82 mm is reached after a typical interblink period for contact lens wearers during attentional visual tasks, it is unlikely to expect a drop of the visual acuity by one log line.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Purpose: The primary objective of the study was to determine differences between in vitro surface de-wetting of soft contact lens (SCL) materials out of saline solution, before and after treatment with phospholipid containing rewetting drops.
Method and Materials: Fifteen lenses of different SCL material classes according to ISO18369 were tested (polymacon, nelfilcon A,
ocufilcon D, balafilcon A, somofilcon A, lotrafilcon B). The lenses were rinsed and stored in saline solution to minimize the effect of the original blister solution. A de-wetting video was captured for every lens using the Keratograph 5M. Afterwards all lenses were soaked in phospholipid containing rewetting solution for 25 hours. The lenses were gently agitated by an orbital shaker with a frequency 0.25 Hz, tilting up to 15°. After treatment, all lenses were equilibrated again in saline solution for at least 30 minutes. De-wetting videos were captured again. In vitro “Non-Invasive Keratograph Dry Up Time“ (NIK-DUT) was assessed for a measurement time of 180 s. The results were expressed by the Area under Curve (AUC) as well as clinical relevant time point to reach 4.82 mm de-wetting.
Results: The AUC results before and after treatment with phospholipid containing rewetting solution were: polymacon 4870.9 ± 942.7 and 6214.1 ± 932.1, nelfilcon A 4688.0 ± 1065.1 and 6959.8 ± 1081.8, ocufilcon D 3612.6 ± 875.5 and 7042.0 ± 714.3, balafilcon A 4170.4 ± 927.2 and 7385.6 ± 879.8, somofilcon A 4284.50 ± 833.8 and 6762.2 ± 1380.2 and lotrafilcon B, comfilcon A 4973.3 ± 1249.3 and 7415.7 ± 994.8. All differences were statistically significant at a significance level of 0.05 with P<0.001 (Wilcoxon rank sum test). The mean time to reach 4.82 mm2 de-wetting was 19 s.
Conclusions: The used phospholipid containing solution did interact with all soft contact lens materials and lead to accelerated in vitro de-wetting. As the de-wetting area of 4.82 mm is reached after a typical interblink period for contact lens wearers during attentional visual tasks, it is unlikely to expect a drop of the visual acuity by one log line.
Purpose: The primary objective of the study was to determine differences between in vitro surface de-wetting of soft contact lens (SCL) materials out of saline solution, before and after treatment with phospholipid containing rewetting drops.
Method and Materials: Fifteen lenses of different SCL material classes according to ISO18369 were tested (polymacon, nelfilcon A,
ocufilcon D, balafilcon A, somofilcon A, lotrafilcon B). The lenses were rinsed and stored in saline solution to minimize the effect of the original blister solution. A de-wetting video was captured for every lens using the Keratograph 5M. Afterwards all lenses were soaked in phospholipid containing rewetting solution for 25 hours. The lenses were gently agitated by an orbital shaker with a frequency 0.25 Hz, tilting up to 15°. After treatment, all lenses were equilibrated again in saline solution for at least 30 minutes. De-wetting videos were captured again. In vitro “Non-Invasive Keratograph Dry Up Time“ (NIK-DUT) was assessed for a measurement time of 180 s. The results were expressed by the Area under Curve (AUC) as well as clinical relevant time point to reach 4.82 mm de-wetting.
Results: The AUC results before and after treatment with phospholipid containing rewetting solution were: polymacon 4870.9 ± 942.7 and 6214.1 ± 932.1, nelfilcon A 4688.0 ± 1065.1 and 6959.8 ± 1081.8, ocufilcon D 3612.6 ± 875.5 and 7042.0 ± 714.3, balafilcon A 4170.4 ± 927.2 and 7385.6 ± 879.8, somofilcon A 4284.50 ± 833.8 and 6762.2 ± 1380.2 and lotrafilcon B, comfilcon A 4973.3 ± 1249.3 and 7415.7 ± 994.8. All differences were statistically significant at a significance level of 0.05 with P<0.001 (Wilcoxon rank sum test). The mean time to reach 4.82 mm2 de-wetting was 19 s.
Conclusions: The used phospholipid containing solution did interact with all soft contact lens materials and lead to accelerated in vitro de-wetting. As the de-wetting area of 4.82 mm is reached after a typical interblink period for contact lens wearers during attentional visual tasks, it is unlikely to expect a drop of the visual acuity by one log line.
Kaymak, Hakan; Neller, Kai; Schütz, Saskia; Graff, Birte; Sickenberger, Wolfgang; Langenbucher, Achim; Seitz, Berthold; Schwahn, Hartmut
Vision tests on spectacle lenses and contact lenses for optical myopia correction: a pilot study Journal Article
In: BMJ Open Ophthalmology, 2022.
@article{Kaymak2022,
title = {Vision tests on spectacle lenses and contact lenses for optical myopia correction: a pilot study},
author = {Hakan Kaymak and Kai Neller and Saskia Schütz and Birte Graff and Wolfgang Sickenberger and Achim Langenbucher and Berthold Seitz and Hartmut Schwahn},
doi = {10.1136/bmjophth-2022-000971 },
year = {2022},
date = {2022-04-05},
urldate = {2022-04-05},
journal = {BMJ Open Ophthalmology},
abstract = {Abstract
Purpose: Visual performance and short-term tolerability of different designs of myopia correcting options, including therapeutically relevant bifocal contact lenses (CL) and spectacle lenses with ‘defocus incorporated multiple segments (DIMS)’ technology were compared.
Methods: In myopic volunteering subjects (n=8; spherical equivalent range: −1 to −7 D) visual acuity (VA) using Landolt C and contrast sensitivity (CS) using contrast C were assessed at three different gaze positions (−22° nasal, +22° temporal and 0° central), corresponding to a gaze through the DIMS area or the clear area of the DIMS lens design, respectively, after short-term wear of each of single vision spectacle lenses (SV), DIMS spectacle lenses (DIMS), monofocal soft CL and centre-near multifocal soft CL (MCL). Also, CS was assessed under photopic and mesopic light conditions with and without glare using sinusoidal gratings at 1.5, 3, 6, 12 and 18 cpd.
Results: Mean VA (Landolt C) was −0.12 to –0.10, −0.05 and 0.10 logMAR (SV, DIMS, CL, MCL) at central gaze (0°). At nasal gaze (−22°), VA differed by 0.12, 0.33, 0.05 and 0.01, and at temporal gaze (+22°) by 0.05, 0.26, 0 and −0.08 compared with central gaze values. Mean CS (Contrast C) was 1.74, 1.73, 1.69 and 1.61 logCS (SV, DIMS, CL, MCL) at central gaze at nasal gaze, CS differed by −0.02 to –0.13, −0.01 and −0.01, and at temporal gaze by −0.02 to –0.16, −0.01 and +0.06 compared with central gaze values.
Conclusion: When compared with SV, MCL leads to a general decrease in VA and CS, while DIMS did not differ from SV at straight gaze (0° gaze). With DIMS, VA and CS are decreased to a similar level as with the MCL, but only at nasal and temporal gaze.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Purpose: Visual performance and short-term tolerability of different designs of myopia correcting options, including therapeutically relevant bifocal contact lenses (CL) and spectacle lenses with ‘defocus incorporated multiple segments (DIMS)’ technology were compared.
Methods: In myopic volunteering subjects (n=8; spherical equivalent range: −1 to −7 D) visual acuity (VA) using Landolt C and contrast sensitivity (CS) using contrast C were assessed at three different gaze positions (−22° nasal, +22° temporal and 0° central), corresponding to a gaze through the DIMS area or the clear area of the DIMS lens design, respectively, after short-term wear of each of single vision spectacle lenses (SV), DIMS spectacle lenses (DIMS), monofocal soft CL and centre-near multifocal soft CL (MCL). Also, CS was assessed under photopic and mesopic light conditions with and without glare using sinusoidal gratings at 1.5, 3, 6, 12 and 18 cpd.
Results: Mean VA (Landolt C) was −0.12 to –0.10, −0.05 and 0.10 logMAR (SV, DIMS, CL, MCL) at central gaze (0°). At nasal gaze (−22°), VA differed by 0.12, 0.33, 0.05 and 0.01, and at temporal gaze (+22°) by 0.05, 0.26, 0 and −0.08 compared with central gaze values. Mean CS (Contrast C) was 1.74, 1.73, 1.69 and 1.61 logCS (SV, DIMS, CL, MCL) at central gaze at nasal gaze, CS differed by −0.02 to –0.13, −0.01 and −0.01, and at temporal gaze by −0.02 to –0.16, −0.01 and +0.06 compared with central gaze values.
Conclusion: When compared with SV, MCL leads to a general decrease in VA and CS, while DIMS did not differ from SV at straight gaze (0° gaze). With DIMS, VA and CS are decreased to a similar level as with the MCL, but only at nasal and temporal gaze.
Purpose: Visual performance and short-term tolerability of different designs of myopia correcting options, including therapeutically relevant bifocal contact lenses (CL) and spectacle lenses with ‘defocus incorporated multiple segments (DIMS)’ technology were compared.
Methods: In myopic volunteering subjects (n=8; spherical equivalent range: −1 to −7 D) visual acuity (VA) using Landolt C and contrast sensitivity (CS) using contrast C were assessed at three different gaze positions (−22° nasal, +22° temporal and 0° central), corresponding to a gaze through the DIMS area or the clear area of the DIMS lens design, respectively, after short-term wear of each of single vision spectacle lenses (SV), DIMS spectacle lenses (DIMS), monofocal soft CL and centre-near multifocal soft CL (MCL). Also, CS was assessed under photopic and mesopic light conditions with and without glare using sinusoidal gratings at 1.5, 3, 6, 12 and 18 cpd.
Results: Mean VA (Landolt C) was −0.12 to –0.10, −0.05 and 0.10 logMAR (SV, DIMS, CL, MCL) at central gaze (0°). At nasal gaze (−22°), VA differed by 0.12, 0.33, 0.05 and 0.01, and at temporal gaze (+22°) by 0.05, 0.26, 0 and −0.08 compared with central gaze values. Mean CS (Contrast C) was 1.74, 1.73, 1.69 and 1.61 logCS (SV, DIMS, CL, MCL) at central gaze at nasal gaze, CS differed by −0.02 to –0.13, −0.01 and −0.01, and at temporal gaze by −0.02 to –0.16, −0.01 and +0.06 compared with central gaze values.
Conclusion: When compared with SV, MCL leads to a general decrease in VA and CS, while DIMS did not differ from SV at straight gaze (0° gaze). With DIMS, VA and CS are decreased to a similar level as with the MCL, but only at nasal and temporal gaze.
von Ahrenschildt, Anke; Hanenberg, Laura; Robich, Matthew L.; Jones-Jordan, Lisa A.; Marx, Sebastian; Sickenberger, Wolfgang; Powell, Daniel R.; Kwan, Justin T.; Wong, Stephanie; Srinivasan, Sruthi; Jones, Lyndon; Pucker, Andrew D.
Morphological Characteristics of Meibomian Glands and their Influence on Dry Eye Disease Journal Article
In: The Ocular Surface, iss. 24, pp. 93-99, 2022.
@article{nokey,
title = {Morphological Characteristics of Meibomian Glands and their Influence on Dry Eye Disease},
author = {Anke von Ahrenschildt and Laura Hanenberg and Matthew L. Robich and Lisa A. Jones-Jordan and Sebastian Marx and Wolfgang Sickenberger and Daniel R. Powell and Justin T. Kwan and Stephanie Wong and Sruthi Srinivasan and Lyndon Jones and Andrew D. Pucker },
doi = { 10.1016/j.jtos.2022.01.002},
year = {2022},
date = {2022-04-01},
urldate = {2022-04-01},
journal = {The Ocular Surface},
issue = {24},
pages = {93-99},
abstract = {Abstract
Purpose: Meibomian glands (MG) are now easily imaged via clinical meibography machines. The purpose of this work was to evaluate the utility of the known MG morphology metrics for predicting dry eye disease (DED).
Methods: Successful and past contact lens wearers were recruited. DED was diagnosed if the participant’s worst eye had a positive tear meniscus height (TMH) (<0.2 mm) test or non-invasive tear break-up time (NITBUT) (<10 s) and a Standardized Patient Evaluation of Eye Dryness (SPEED) score >5.0. Meibography was performed and images were subjectively graded by two examiners for the following MG characteristics: distorted, tortuous, hooked, abnormal gap, overlapping, fluffy areas, tadpoling, thinned, thickened, ghost, no extension to lid margin, shortened and dropout (atrophy). DED diagnostic ability of each metric was determined with receiver operating characteristic (ROC) analysis.
Results: A total of 112 participants were recruited with 18.8% of them having DED and 60.7% of them being female. The only MG morphology metrics that were marginally predictive of DED were thickened upper eyelid MGs (p = 0.046), thickened mean upper plus lower eyelid MGs (p = 0.007), and atrophy of (total number) upper eyelid MGs (p = 0.043); however, none of these metrics reached a meaningful area under the curve in ROC analysis (all < 0.70).
Conclusion: While abnormal MG morphology is likely suggestive of DED, none of the MG morphology metrics evaluated alone in this study had clinically meaningful predictive value for detecting DED in this group of current and past contact lens wearers.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Purpose: Meibomian glands (MG) are now easily imaged via clinical meibography machines. The purpose of this work was to evaluate the utility of the known MG morphology metrics for predicting dry eye disease (DED).
Methods: Successful and past contact lens wearers were recruited. DED was diagnosed if the participant’s worst eye had a positive tear meniscus height (TMH) (<0.2 mm) test or non-invasive tear break-up time (NITBUT) (<10 s) and a Standardized Patient Evaluation of Eye Dryness (SPEED) score >5.0. Meibography was performed and images were subjectively graded by two examiners for the following MG characteristics: distorted, tortuous, hooked, abnormal gap, overlapping, fluffy areas, tadpoling, thinned, thickened, ghost, no extension to lid margin, shortened and dropout (atrophy). DED diagnostic ability of each metric was determined with receiver operating characteristic (ROC) analysis.
Results: A total of 112 participants were recruited with 18.8% of them having DED and 60.7% of them being female. The only MG morphology metrics that were marginally predictive of DED were thickened upper eyelid MGs (p = 0.046), thickened mean upper plus lower eyelid MGs (p = 0.007), and atrophy of (total number) upper eyelid MGs (p = 0.043); however, none of these metrics reached a meaningful area under the curve in ROC analysis (all < 0.70).
Conclusion: While abnormal MG morphology is likely suggestive of DED, none of the MG morphology metrics evaluated alone in this study had clinically meaningful predictive value for detecting DED in this group of current and past contact lens wearers.
Purpose: Meibomian glands (MG) are now easily imaged via clinical meibography machines. The purpose of this work was to evaluate the utility of the known MG morphology metrics for predicting dry eye disease (DED).
Methods: Successful and past contact lens wearers were recruited. DED was diagnosed if the participant’s worst eye had a positive tear meniscus height (TMH) (<0.2 mm) test or non-invasive tear break-up time (NITBUT) (<10 s) and a Standardized Patient Evaluation of Eye Dryness (SPEED) score >5.0. Meibography was performed and images were subjectively graded by two examiners for the following MG characteristics: distorted, tortuous, hooked, abnormal gap, overlapping, fluffy areas, tadpoling, thinned, thickened, ghost, no extension to lid margin, shortened and dropout (atrophy). DED diagnostic ability of each metric was determined with receiver operating characteristic (ROC) analysis.
Results: A total of 112 participants were recruited with 18.8% of them having DED and 60.7% of them being female. The only MG morphology metrics that were marginally predictive of DED were thickened upper eyelid MGs (p = 0.046), thickened mean upper plus lower eyelid MGs (p = 0.007), and atrophy of (total number) upper eyelid MGs (p = 0.043); however, none of these metrics reached a meaningful area under the curve in ROC analysis (all < 0.70).
Conclusion: While abnormal MG morphology is likely suggestive of DED, none of the MG morphology metrics evaluated alone in this study had clinically meaningful predictive value for detecting DED in this group of current and past contact lens wearers.
Jäger, Claudio; Marx, Sebastian; Eckstein, Julia; Sickenberger, Wolfgang
MGD Treatment using Intense Pulsed Light and Low Level Light Therapy Journal Article
In: Optometry and Contact Lenses , iss. Vol. 2 2022, pp. 44-50, 2022.
@article{Jäger2022,
title = {MGD Treatment using Intense Pulsed Light and Low Level Light Therapy},
author = {Claudio Jäger and Sebastian Marx and Julia Eckstein and Wolfgang Sickenberger },
doi = {doi.org/10.54352/dozv.VAGF2518 },
year = {2022},
date = {2022-02-25},
urldate = {2022-02-25},
journal = {Optometry and Contact Lenses },
issue = {Vol. 2 2022},
pages = {44-50},
abstract = {Abstract
Purpose: Primary objective of this study was the assessment of dry eye related subjective and objective findings of MGD patients prior and after IPL and LLLT treatment.
Material and Methods: 38 subjects with diagnosed MGD were enrolled in a prospective single center study in an optometric practice based in Wil (Switzerland). All subjects underwent IPL / LLLT treatments every 14 days from baseline until four treatments were conducted. OSDI, BCVA, IOP, NIKBUT, osmolarity, lower lid margin appearance and meibography data were captured at baseline before the first IPL/ LLLT treatment and 14 days after the last treatment.
Pre and post OSDI score, NIKBUT and osmolarity of the right was statistically analyzed using Wilcoxon rang sum test for matched pairs.
Results: OSDI score decreased significantly from 32 to 14 (p = <0.001). NIKBUT values did not increased significantly from 11.4 ± 12.4 s to 11.7 ± 5.9 (p = 0.498). Osmolarity increased significantly from 322.2 ± 12.6 mOsm/L to 327.9 ± 9.6 (p = 0.006). 26 of 38 subjects (68.4 %) were satisfied or very satisfied by this new form of therapy whereas 12 subjects (31.6 %) did not report a subjective change.
Conclusion: The combined IPL / LLLT therapy is a promising therapy form usable in optometric and ophthalmological practices. The majority of the subjects reported subjective improvements, which were not confirmed by objective findings. Due to the high reduction of sicca symptoms and the high degree of satisfaction with the IPL / LLLT treatment, it can be stated, that an IPL / LLLT application is effective in MGD patients.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Purpose: Primary objective of this study was the assessment of dry eye related subjective and objective findings of MGD patients prior and after IPL and LLLT treatment.
Material and Methods: 38 subjects with diagnosed MGD were enrolled in a prospective single center study in an optometric practice based in Wil (Switzerland). All subjects underwent IPL / LLLT treatments every 14 days from baseline until four treatments were conducted. OSDI, BCVA, IOP, NIKBUT, osmolarity, lower lid margin appearance and meibography data were captured at baseline before the first IPL/ LLLT treatment and 14 days after the last treatment.
Pre and post OSDI score, NIKBUT and osmolarity of the right was statistically analyzed using Wilcoxon rang sum test for matched pairs.
Results: OSDI score decreased significantly from 32 to 14 (p = <0.001). NIKBUT values did not increased significantly from 11.4 ± 12.4 s to 11.7 ± 5.9 (p = 0.498). Osmolarity increased significantly from 322.2 ± 12.6 mOsm/L to 327.9 ± 9.6 (p = 0.006). 26 of 38 subjects (68.4 %) were satisfied or very satisfied by this new form of therapy whereas 12 subjects (31.6 %) did not report a subjective change.
Conclusion: The combined IPL / LLLT therapy is a promising therapy form usable in optometric and ophthalmological practices. The majority of the subjects reported subjective improvements, which were not confirmed by objective findings. Due to the high reduction of sicca symptoms and the high degree of satisfaction with the IPL / LLLT treatment, it can be stated, that an IPL / LLLT application is effective in MGD patients.
Purpose: Primary objective of this study was the assessment of dry eye related subjective and objective findings of MGD patients prior and after IPL and LLLT treatment.
Material and Methods: 38 subjects with diagnosed MGD were enrolled in a prospective single center study in an optometric practice based in Wil (Switzerland). All subjects underwent IPL / LLLT treatments every 14 days from baseline until four treatments were conducted. OSDI, BCVA, IOP, NIKBUT, osmolarity, lower lid margin appearance and meibography data were captured at baseline before the first IPL/ LLLT treatment and 14 days after the last treatment.
Pre and post OSDI score, NIKBUT and osmolarity of the right was statistically analyzed using Wilcoxon rang sum test for matched pairs.
Results: OSDI score decreased significantly from 32 to 14 (p = <0.001). NIKBUT values did not increased significantly from 11.4 ± 12.4 s to 11.7 ± 5.9 (p = 0.498). Osmolarity increased significantly from 322.2 ± 12.6 mOsm/L to 327.9 ± 9.6 (p = 0.006). 26 of 38 subjects (68.4 %) were satisfied or very satisfied by this new form of therapy whereas 12 subjects (31.6 %) did not report a subjective change.
Conclusion: The combined IPL / LLLT therapy is a promising therapy form usable in optometric and ophthalmological practices. The majority of the subjects reported subjective improvements, which were not confirmed by objective findings. Due to the high reduction of sicca symptoms and the high degree of satisfaction with the IPL / LLLT treatment, it can be stated, that an IPL / LLLT application is effective in MGD patients.
2021
Marx, Sebastian; Schwarz, Stefan; Keller, Katharina; Sickenberger, Wolfgang
2021.
@conference{Marx2021,
title = {Change in objective ocular redness and symptoms after refit of weekly and monthly lenses into a water-gradient daily disposable lens material},
author = {Sebastian Marx and Stefan Schwarz and Katharina Keller and Wolfgang Sickenberger},
editor = {Sebastian Marx},
url = {https://www.jenvis-research.com/wp-content/uploads/2021/10/Jenvis-AAO-Poster-2021-NOV2021-1.pdf},
year = {2021},
date = {2021-11-04},
urldate = {2021-11-04},
abstract = {Abstract
Purpose: Primary objective of the study is the evaluation of change in ocular redness when a water gradient DD SiHy Lens (Delefilcon A) is refitted to 2-4 week CL wearers.
Material and Methods: 52 habitual, asymptomatic, full time SCL wearers with spherical correction were enrolled in a prospective single center study. At the baseline visit bulbar and limbal redness were measured objectively using the Oculus K5M Redness-Scan mode. Lens care type, comfort ratings and staining data was captured as well. Comfort after insertion, during the day as well as the end of day comfort was obtained using a 101 point visual analog scale. The comfort rating were averaged in this abstract. A wash out phase of 6 ± 1 days was conducted in which the subjects didn´t wear any lenses before Delefilcon A lenses were dispensed at visit 2 for a wearing period of 26 ± 5 days. A follow up visit was planned after 6 ± 1 days from V2 and a final visit after additional 20 ± 4 days. During visit 2, 3 and 4 the same objective measurements were carried out and corresponding subjective data was captured. Wilcoxon signed rank test and t-test for paired samples were used for the statistical analyses.
Results: 50 subjects completed the study. Following results, refer to the right eyes only. Objectively measured bulbar redness decreased by 0.11 (p=0.012) from baseline in comparison to the final visit. In the same period limbal redness reduced by 0.20 (<0.001), corneal staining by 0.24 (p=0.014) and conjunctival staining by 0.16 (p=0.046). In contrast to the objective findings, subjective ratings increased. The averaged comfort rating with habitual lenses was 79.29, after the wash out phase with no lens wear 85.91, during the first follow up visit with Delefilcon A lenses 86.83 and at the final visit 89.12.
Conclusion:
Although the difference is small in context of our classic subjective grading habits, which uses fully grades in 1.0 steps, the Oculus K5M was able to detect fine graduated differences in the cohort of non-symptomatic wearers, which didn´t show high redness scores. Delefilcon A material delivers benefits to wearers in form of reduced bulbar and limbal redness, reduced corneal and conjunctival staining and increased wearing comfort.
Key words: bulbar redness, limbal redness, staining, soft contact lenses
},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: Primary objective of the study is the evaluation of change in ocular redness when a water gradient DD SiHy Lens (Delefilcon A) is refitted to 2-4 week CL wearers.
Material and Methods: 52 habitual, asymptomatic, full time SCL wearers with spherical correction were enrolled in a prospective single center study. At the baseline visit bulbar and limbal redness were measured objectively using the Oculus K5M Redness-Scan mode. Lens care type, comfort ratings and staining data was captured as well. Comfort after insertion, during the day as well as the end of day comfort was obtained using a 101 point visual analog scale. The comfort rating were averaged in this abstract. A wash out phase of 6 ± 1 days was conducted in which the subjects didn´t wear any lenses before Delefilcon A lenses were dispensed at visit 2 for a wearing period of 26 ± 5 days. A follow up visit was planned after 6 ± 1 days from V2 and a final visit after additional 20 ± 4 days. During visit 2, 3 and 4 the same objective measurements were carried out and corresponding subjective data was captured. Wilcoxon signed rank test and t-test for paired samples were used for the statistical analyses.
Results: 50 subjects completed the study. Following results, refer to the right eyes only. Objectively measured bulbar redness decreased by 0.11 (p=0.012) from baseline in comparison to the final visit. In the same period limbal redness reduced by 0.20 (<0.001), corneal staining by 0.24 (p=0.014) and conjunctival staining by 0.16 (p=0.046). In contrast to the objective findings, subjective ratings increased. The averaged comfort rating with habitual lenses was 79.29, after the wash out phase with no lens wear 85.91, during the first follow up visit with Delefilcon A lenses 86.83 and at the final visit 89.12.
Conclusion:
Although the difference is small in context of our classic subjective grading habits, which uses fully grades in 1.0 steps, the Oculus K5M was able to detect fine graduated differences in the cohort of non-symptomatic wearers, which didn´t show high redness scores. Delefilcon A material delivers benefits to wearers in form of reduced bulbar and limbal redness, reduced corneal and conjunctival staining and increased wearing comfort.
Key words: bulbar redness, limbal redness, staining, soft contact lenses
Purpose: Primary objective of the study is the evaluation of change in ocular redness when a water gradient DD SiHy Lens (Delefilcon A) is refitted to 2-4 week CL wearers.
Material and Methods: 52 habitual, asymptomatic, full time SCL wearers with spherical correction were enrolled in a prospective single center study. At the baseline visit bulbar and limbal redness were measured objectively using the Oculus K5M Redness-Scan mode. Lens care type, comfort ratings and staining data was captured as well. Comfort after insertion, during the day as well as the end of day comfort was obtained using a 101 point visual analog scale. The comfort rating were averaged in this abstract. A wash out phase of 6 ± 1 days was conducted in which the subjects didn´t wear any lenses before Delefilcon A lenses were dispensed at visit 2 for a wearing period of 26 ± 5 days. A follow up visit was planned after 6 ± 1 days from V2 and a final visit after additional 20 ± 4 days. During visit 2, 3 and 4 the same objective measurements were carried out and corresponding subjective data was captured. Wilcoxon signed rank test and t-test for paired samples were used for the statistical analyses.
Results: 50 subjects completed the study. Following results, refer to the right eyes only. Objectively measured bulbar redness decreased by 0.11 (p=0.012) from baseline in comparison to the final visit. In the same period limbal redness reduced by 0.20 (<0.001), corneal staining by 0.24 (p=0.014) and conjunctival staining by 0.16 (p=0.046). In contrast to the objective findings, subjective ratings increased. The averaged comfort rating with habitual lenses was 79.29, after the wash out phase with no lens wear 85.91, during the first follow up visit with Delefilcon A lenses 86.83 and at the final visit 89.12.
Conclusion:
Although the difference is small in context of our classic subjective grading habits, which uses fully grades in 1.0 steps, the Oculus K5M was able to detect fine graduated differences in the cohort of non-symptomatic wearers, which didn´t show high redness scores. Delefilcon A material delivers benefits to wearers in form of reduced bulbar and limbal redness, reduced corneal and conjunctival staining and increased wearing comfort.
Key words: bulbar redness, limbal redness, staining, soft contact lenses
Kapfelsberger, Andrea; Eckstein, Julia; von Ahrentschildt, Anke; Bischoff, Jürgen; Marx, Sebastian; Sickenberger, Wolfgang
Ultraviolet and Visible Transmittance of Soft Contact Lenses with and without Ultraviolet Blockers Journal Article
In: Optometry and Vision Science - Journal of the American Academy of Optometry, 2021.
@article{Kapfelsberger2021,
title = {Ultraviolet and Visible Transmittance of Soft Contact Lenses with and without Ultraviolet Blockers},
author = {Andrea Kapfelsberger and Julia Eckstein and Anke von Ahrentschildt and Jürgen Bischoff and Sebastian Marx and Wolfgang Sickenberger},
url = {https://journals.lww.com/optvissci/Abstract/9000/Ultraviolet_and_Visible_Transmittance_of_Soft.97914.aspx},
doi = {10.1097/OPX.0000000000001796},
year = {2021},
date = {2021-09-30},
urldate = {2021-09-30},
journal = {Optometry and Vision Science - Journal of the American Academy of Optometry},
abstract = {Abstract
Significance: Ultraviolet (UV) and visible light transmittance of soft contact lenses (SCLs) was measured. A significant difference in UV transmittance has been found between SCLs with a positive and negative back vertex power (BVP). It can be shown that thicker SCLs absorb more UV radiation (UVR).
Purpose: To determine UV and visible light transmittance of different soft contact lenses with and without UV protection filters.
Methods:Twenty-one lens brands were investigated in the BVP range of -12.00 D to +6.00 D. Three SCLs were measured per back vertex power 25 times. 339 SCLs with UV filter (stenfilcon A, somofilcon A, narafilcon A, senofilcon A, senofilcon C, etafilcon A, nesofilcon A) and 489 SCLs without UV filter (delefilcon A, lotrafilcon A, lotrafilcon B, comfilcon A, balafilcon A, samfilcon A, asmofilcon A, nelfilcon A, omafilcon A, hilafilcon B, ocufilcon D, hioxifilcon A, omafilcon B) have been examined. The measurement setup was created according to ISO 18369-3.
Results: All UV-absorbing labeled test SCLs meet UV protection class 2. Senofilcon A, senofilcon C and narafilcon A meet the higher UV protection class 1 level. A statistically significant difference in UV transmittance (280 to 380 nm) has been found between SCLs with a positive BVP (+1.00 D to +6.00 D) and SCLs with a negative BVP (-1.00 D to -12.00 D), both without (P = .043) and with UV filters (P = .018)
Conclusions: With the ISO conforming, diopter-independent measurement setup the UV-absorbing test contact lenses that meet the current international standards, regardless of their BVP, were identified. Lenses with increased center thickness absorb more UV radiation. Further studies may use a modified measurement setup with a larger aperture than 10 mm. It would also be worthwhile to examine the ultraviolet absorption of the contact lens over the complete corneal area and limbal area, because UVR may damage inner ocular tissues like the crystalline lens as well as limbal stem cells.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Significance: Ultraviolet (UV) and visible light transmittance of soft contact lenses (SCLs) was measured. A significant difference in UV transmittance has been found between SCLs with a positive and negative back vertex power (BVP). It can be shown that thicker SCLs absorb more UV radiation (UVR).
Purpose: To determine UV and visible light transmittance of different soft contact lenses with and without UV protection filters.
Methods:Twenty-one lens brands were investigated in the BVP range of -12.00 D to +6.00 D. Three SCLs were measured per back vertex power 25 times. 339 SCLs with UV filter (stenfilcon A, somofilcon A, narafilcon A, senofilcon A, senofilcon C, etafilcon A, nesofilcon A) and 489 SCLs without UV filter (delefilcon A, lotrafilcon A, lotrafilcon B, comfilcon A, balafilcon A, samfilcon A, asmofilcon A, nelfilcon A, omafilcon A, hilafilcon B, ocufilcon D, hioxifilcon A, omafilcon B) have been examined. The measurement setup was created according to ISO 18369-3.
Results: All UV-absorbing labeled test SCLs meet UV protection class 2. Senofilcon A, senofilcon C and narafilcon A meet the higher UV protection class 1 level. A statistically significant difference in UV transmittance (280 to 380 nm) has been found between SCLs with a positive BVP (+1.00 D to +6.00 D) and SCLs with a negative BVP (-1.00 D to -12.00 D), both without (P = .043) and with UV filters (P = .018)
Conclusions: With the ISO conforming, diopter-independent measurement setup the UV-absorbing test contact lenses that meet the current international standards, regardless of their BVP, were identified. Lenses with increased center thickness absorb more UV radiation. Further studies may use a modified measurement setup with a larger aperture than 10 mm. It would also be worthwhile to examine the ultraviolet absorption of the contact lens over the complete corneal area and limbal area, because UVR may damage inner ocular tissues like the crystalline lens as well as limbal stem cells.
Significance: Ultraviolet (UV) and visible light transmittance of soft contact lenses (SCLs) was measured. A significant difference in UV transmittance has been found between SCLs with a positive and negative back vertex power (BVP). It can be shown that thicker SCLs absorb more UV radiation (UVR).
Purpose: To determine UV and visible light transmittance of different soft contact lenses with and without UV protection filters.
Methods:Twenty-one lens brands were investigated in the BVP range of -12.00 D to +6.00 D. Three SCLs were measured per back vertex power 25 times. 339 SCLs with UV filter (stenfilcon A, somofilcon A, narafilcon A, senofilcon A, senofilcon C, etafilcon A, nesofilcon A) and 489 SCLs without UV filter (delefilcon A, lotrafilcon A, lotrafilcon B, comfilcon A, balafilcon A, samfilcon A, asmofilcon A, nelfilcon A, omafilcon A, hilafilcon B, ocufilcon D, hioxifilcon A, omafilcon B) have been examined. The measurement setup was created according to ISO 18369-3.
Results: All UV-absorbing labeled test SCLs meet UV protection class 2. Senofilcon A, senofilcon C and narafilcon A meet the higher UV protection class 1 level. A statistically significant difference in UV transmittance (280 to 380 nm) has been found between SCLs with a positive BVP (+1.00 D to +6.00 D) and SCLs with a negative BVP (-1.00 D to -12.00 D), both without (P = .043) and with UV filters (P = .018)
Conclusions: With the ISO conforming, diopter-independent measurement setup the UV-absorbing test contact lenses that meet the current international standards, regardless of their BVP, were identified. Lenses with increased center thickness absorb more UV radiation. Further studies may use a modified measurement setup with a larger aperture than 10 mm. It would also be worthwhile to examine the ultraviolet absorption of the contact lens over the complete corneal area and limbal area, because UVR may damage inner ocular tissues like the crystalline lens as well as limbal stem cells.
2020
Marx, Sebastian; Eckstein, Julia; Sickenberger, Wolfgang
Objective Analysis of Pre-Lens Tear Film Stability of Daily Disposable Contact Lenses Using Ring Mire Projection Journal Article
In: Clinical Optometry, vol. 12, pp. 203-211, 2020.
@article{Marx2020b,
title = {Objective Analysis of Pre-Lens Tear Film Stability of Daily Disposable Contact Lenses Using Ring Mire Projection},
author = {Sebastian Marx and Julia Eckstein and Wolfgang Sickenberger },
url = {https://www.jenvis-research.com/opto-262353-objective-analysis-of-pre-lens-tear-film-stability-of-daily-2/},
doi = {10.2147/OPTO.S262353},
year = {2020},
date = {2020-11-20},
urldate = {2020-11-20},
journal = {Clinical Optometry},
volume = {12},
pages = {203-211},
abstract = {Abstract
Purpose: The primary objective of this study was to evaluate the in vivo pre-lens non-invasive drying-up time of two types of daily disposable contact lenses (DDCLs) after 12 hours of wear.
Methods: This prospective, randomized, single-center, cross-over pilot study evaluated 31 subjects aged 18-44 years with normal eyes and good tear film stability who were adapted current soft contact lens wearers. Subjects wore nelfilcon A and stenfilcon A DDCLs for 12 hours each on two different days. Non-invasive video keratography drying-up time (NIK-DUT) videos of each eye were recorded 12 hours after lens insertion for about 25 seconds, with a 5-minute tear film recovery time allowed between video recordings of the right and left eyes to avoid bias. Post-blink time required to reach 15% distortion of the projected rings and the speed of break-up at 15 seconds post-blink were measured at each time point and on-eye wettability was determined by ring mire projection under white light illumination.
Results: Mean time to reach 15% ring distortion was similar for nelfilcon A (19.25±3.20 sec) and stenfilcon A (20.24±3.02 sec) DDCLs but varied highly among subjects. The mean speed of break-up at 15 sec post-blink was 0.3±0.38% distortion/sec (95% confidence interval [CI] 0.138-0.365% distortion/sec) for nelfilcon A and 0.2±0.23% distortion/sec (95% CI 0.048-0.279% distortion/sec) for stenfilcon A DDCLs.
Conclusion: Multifunctional topography allowed the objective evaluation of in vivo pre-lens tear film stability using ring mire projection. This dynamic method was simple, fast and non-invasive, enabling measurements of NIK-DUT and evaluating wettability over a large area, greater than the optical zone of the contact lens surface, for the entire inter-blink interval.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Purpose: The primary objective of this study was to evaluate the in vivo pre-lens non-invasive drying-up time of two types of daily disposable contact lenses (DDCLs) after 12 hours of wear.
Methods: This prospective, randomized, single-center, cross-over pilot study evaluated 31 subjects aged 18-44 years with normal eyes and good tear film stability who were adapted current soft contact lens wearers. Subjects wore nelfilcon A and stenfilcon A DDCLs for 12 hours each on two different days. Non-invasive video keratography drying-up time (NIK-DUT) videos of each eye were recorded 12 hours after lens insertion for about 25 seconds, with a 5-minute tear film recovery time allowed between video recordings of the right and left eyes to avoid bias. Post-blink time required to reach 15% distortion of the projected rings and the speed of break-up at 15 seconds post-blink were measured at each time point and on-eye wettability was determined by ring mire projection under white light illumination.
Results: Mean time to reach 15% ring distortion was similar for nelfilcon A (19.25±3.20 sec) and stenfilcon A (20.24±3.02 sec) DDCLs but varied highly among subjects. The mean speed of break-up at 15 sec post-blink was 0.3±0.38% distortion/sec (95% confidence interval [CI] 0.138-0.365% distortion/sec) for nelfilcon A and 0.2±0.23% distortion/sec (95% CI 0.048-0.279% distortion/sec) for stenfilcon A DDCLs.
Conclusion: Multifunctional topography allowed the objective evaluation of in vivo pre-lens tear film stability using ring mire projection. This dynamic method was simple, fast and non-invasive, enabling measurements of NIK-DUT and evaluating wettability over a large area, greater than the optical zone of the contact lens surface, for the entire inter-blink interval.
Purpose: The primary objective of this study was to evaluate the in vivo pre-lens non-invasive drying-up time of two types of daily disposable contact lenses (DDCLs) after 12 hours of wear.
Methods: This prospective, randomized, single-center, cross-over pilot study evaluated 31 subjects aged 18-44 years with normal eyes and good tear film stability who were adapted current soft contact lens wearers. Subjects wore nelfilcon A and stenfilcon A DDCLs for 12 hours each on two different days. Non-invasive video keratography drying-up time (NIK-DUT) videos of each eye were recorded 12 hours after lens insertion for about 25 seconds, with a 5-minute tear film recovery time allowed between video recordings of the right and left eyes to avoid bias. Post-blink time required to reach 15% distortion of the projected rings and the speed of break-up at 15 seconds post-blink were measured at each time point and on-eye wettability was determined by ring mire projection under white light illumination.
Results: Mean time to reach 15% ring distortion was similar for nelfilcon A (19.25±3.20 sec) and stenfilcon A (20.24±3.02 sec) DDCLs but varied highly among subjects. The mean speed of break-up at 15 sec post-blink was 0.3±0.38% distortion/sec (95% confidence interval [CI] 0.138-0.365% distortion/sec) for nelfilcon A and 0.2±0.23% distortion/sec (95% CI 0.048-0.279% distortion/sec) for stenfilcon A DDCLs.
Conclusion: Multifunctional topography allowed the objective evaluation of in vivo pre-lens tear film stability using ring mire projection. This dynamic method was simple, fast and non-invasive, enabling measurements of NIK-DUT and evaluating wettability over a large area, greater than the optical zone of the contact lens surface, for the entire inter-blink interval.
Jäger, Claudio; Marx, Sebastian; Eckstein, Julia; Sickenberger, Wolfgang
American Academy of Optometry 2020.
@conference{Jäger2020,
title = {Prospective Longitudinal-Study of the therapy of MGD-Patients using Intense Pulsed Light (IPL) and Low Level Light Therapy (LLLT)},
author = {Claudio Jäger and Sebastian Marx and Julia Eckstein and Wolfgang Sickenberger },
url = {https://www.jenvis-research.com/wp-content/uploads/2020/10/Poster-AAO-2020-Claudio-Jager-englisch-2.pdf},
doi = {10.13140/RG.2.2.28329.01128},
year = {2020},
date = {2020-10-07},
urldate = {2020-10-07},
organization = {American Academy of Optometry },
abstract = {Abstract
Purpose: Primary objective of this study was the assessment of dry eye related subjective and objective findings of MGD patients prior and after IPL and LLLT treatment.
Material and Methods: 38 subjects with diagnosed MGD were enrolled in a prospective single center study in an optometric practice based in Wil (Switzerland). All subjects underwent IPL / LLLT treatments every 14 days from baseline until four treatments were conducted. OSDI, BCVA, IOP, NIKBUT, osmolarity, lower lid margin appearance and meibography data was captured at baseline before the first IPL/ LLLT treatment and 14 days after the last treatment. Pre and post NIKBUT, osmolarity and OSDI data of the right and left eye was statistically analyzed using Wilcoxon rang sum test for matched pairs.
Results: NIKBUT values increased not significantly OD from 9.5sec to 11sec (p = 0.498) and OS from 8sec to post IPL 12sec (p = 0.056). Osmolarity increased significantly OD from 322.21mOsm/L to 327.92mOsm/L (p = 0.006) and OS from 319.24mOsm/L to post 323.24mOsm/L (p = 0.097). OSDI score decreased significantly from 31.5 to 11 (p = <0.001). 26 of 38 subjects (68.4%) were satisfied or very satisfied by this new form of therapy whereas 12 subjects (31.6%) didn´t report a subjective change.
Conclusion: The combined IPL / LLLT therapy is a promising therapy form usable in optometric and ophthalmological practices. The majority of the subjects reported improvements which matches partly objective findings but osmolarity which didn´t decrease. Rooms temperature changes haven´t been controlled but could potentially influence osmolarity readings. Further studies should take this into account and could asses further IPL treatment combinations.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: Primary objective of this study was the assessment of dry eye related subjective and objective findings of MGD patients prior and after IPL and LLLT treatment.
Material and Methods: 38 subjects with diagnosed MGD were enrolled in a prospective single center study in an optometric practice based in Wil (Switzerland). All subjects underwent IPL / LLLT treatments every 14 days from baseline until four treatments were conducted. OSDI, BCVA, IOP, NIKBUT, osmolarity, lower lid margin appearance and meibography data was captured at baseline before the first IPL/ LLLT treatment and 14 days after the last treatment. Pre and post NIKBUT, osmolarity and OSDI data of the right and left eye was statistically analyzed using Wilcoxon rang sum test for matched pairs.
Results: NIKBUT values increased not significantly OD from 9.5sec to 11sec (p = 0.498) and OS from 8sec to post IPL 12sec (p = 0.056). Osmolarity increased significantly OD from 322.21mOsm/L to 327.92mOsm/L (p = 0.006) and OS from 319.24mOsm/L to post 323.24mOsm/L (p = 0.097). OSDI score decreased significantly from 31.5 to 11 (p = <0.001). 26 of 38 subjects (68.4%) were satisfied or very satisfied by this new form of therapy whereas 12 subjects (31.6%) didn´t report a subjective change.
Conclusion: The combined IPL / LLLT therapy is a promising therapy form usable in optometric and ophthalmological practices. The majority of the subjects reported improvements which matches partly objective findings but osmolarity which didn´t decrease. Rooms temperature changes haven´t been controlled but could potentially influence osmolarity readings. Further studies should take this into account and could asses further IPL treatment combinations.
Purpose: Primary objective of this study was the assessment of dry eye related subjective and objective findings of MGD patients prior and after IPL and LLLT treatment.
Material and Methods: 38 subjects with diagnosed MGD were enrolled in a prospective single center study in an optometric practice based in Wil (Switzerland). All subjects underwent IPL / LLLT treatments every 14 days from baseline until four treatments were conducted. OSDI, BCVA, IOP, NIKBUT, osmolarity, lower lid margin appearance and meibography data was captured at baseline before the first IPL/ LLLT treatment and 14 days after the last treatment. Pre and post NIKBUT, osmolarity and OSDI data of the right and left eye was statistically analyzed using Wilcoxon rang sum test for matched pairs.
Results: NIKBUT values increased not significantly OD from 9.5sec to 11sec (p = 0.498) and OS from 8sec to post IPL 12sec (p = 0.056). Osmolarity increased significantly OD from 322.21mOsm/L to 327.92mOsm/L (p = 0.006) and OS from 319.24mOsm/L to post 323.24mOsm/L (p = 0.097). OSDI score decreased significantly from 31.5 to 11 (p = <0.001). 26 of 38 subjects (68.4%) were satisfied or very satisfied by this new form of therapy whereas 12 subjects (31.6%) didn´t report a subjective change.
Conclusion: The combined IPL / LLLT therapy is a promising therapy form usable in optometric and ophthalmological practices. The majority of the subjects reported improvements which matches partly objective findings but osmolarity which didn´t decrease. Rooms temperature changes haven´t been controlled but could potentially influence osmolarity readings. Further studies should take this into account and could asses further IPL treatment combinations.
Marx, Sebastian; Eckstein, Julia; Zimmermann, Felix; Sickenberger, Wolfgang
Solution Related in Vitro Dewetting behavior of Different Soft Contact Lens Materials Conference
American Academy of Optometry 2020.
@conference{Marx2020c,
title = {Solution Related in Vitro Dewetting behavior of Different Soft Contact Lens Materials},
author = {Sebastian Marx and Julia Eckstein and Felix Zimmermann and Wolfgang Sickenberger},
url = {https://www.jenvis-research.com/wp-content/uploads/2020/10/Poster-AAO-2020-Marx-et-al-Solution-Related-in-Vitro-Dewetting-behavior-of-Different-Soft-Contact-Lens-Materials-4.pdf},
doi = {10.13140/RG.2.2.15431.52645},
year = {2020},
date = {2020-10-07},
urldate = {2020-10-07},
organization = {American Academy of Optometry },
abstract = {Abstract
Purpose: In vitro dewetting characteristics of different silicone hydrogel daily disposable contact lenses were measured out of their specific blister solution using Non-Invasive Keratograph Drying-Up Time procedure to determine short-term dewetting characteristics. In vitro dewetting characteristic curves of same CL materials soaked in saline solution (control solution) and artificial tear solution (ATS) were measured to determine additional dewetting characteristics.
Materials: Non-Invasive Keratograph Drying-Up Time was measured for six different CL materials including Nelfilcon A, Delefilcon A, Senofilcon A, Stenfilcon A, Somofilcon A and Narafilcon A out of their specific blister solution, out of saline and out of ATS. For soaking the lenses in saline or ATS, all lenses were rinsed with saline to remove blister solution. 20 lenses of each solution/ material combination were measured. In vitro dewetting behavior of these lenses over 180 seconds was determined and expressed by area under curve values (AUC).
Results: Fasted dewetting occurred for all materials when measured out of saline solution, indicated by the highest averaged AUC value over all lens materials of 9243,3 ± 38,3. Slower dewetting was detected for all materials when measured out of their specific blister solution 7755,9 ± 37,1 and out of ATS 7988,8 ± 40,0. Intra group results were statistically different (Kruskal-Wallis) with p<0,001 for saline and blister solution. Intra group differences were smaller for ATS but also statistically different p<0,05.
Conclusion: Pure saline solution leads to faster in vitro dewetting for all materials in comparison to their specific blister solution or ATS. In vitro dewetting experiments focused on saline only, may show bigger differences as present in reality. The use of ATS allows to decrease the gap between in vitro and in vivo measurements.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: In vitro dewetting characteristics of different silicone hydrogel daily disposable contact lenses were measured out of their specific blister solution using Non-Invasive Keratograph Drying-Up Time procedure to determine short-term dewetting characteristics. In vitro dewetting characteristic curves of same CL materials soaked in saline solution (control solution) and artificial tear solution (ATS) were measured to determine additional dewetting characteristics.
Materials: Non-Invasive Keratograph Drying-Up Time was measured for six different CL materials including Nelfilcon A, Delefilcon A, Senofilcon A, Stenfilcon A, Somofilcon A and Narafilcon A out of their specific blister solution, out of saline and out of ATS. For soaking the lenses in saline or ATS, all lenses were rinsed with saline to remove blister solution. 20 lenses of each solution/ material combination were measured. In vitro dewetting behavior of these lenses over 180 seconds was determined and expressed by area under curve values (AUC).
Results: Fasted dewetting occurred for all materials when measured out of saline solution, indicated by the highest averaged AUC value over all lens materials of 9243,3 ± 38,3. Slower dewetting was detected for all materials when measured out of their specific blister solution 7755,9 ± 37,1 and out of ATS 7988,8 ± 40,0. Intra group results were statistically different (Kruskal-Wallis) with p<0,001 for saline and blister solution. Intra group differences were smaller for ATS but also statistically different p<0,05.
Conclusion: Pure saline solution leads to faster in vitro dewetting for all materials in comparison to their specific blister solution or ATS. In vitro dewetting experiments focused on saline only, may show bigger differences as present in reality. The use of ATS allows to decrease the gap between in vitro and in vivo measurements.
Purpose: In vitro dewetting characteristics of different silicone hydrogel daily disposable contact lenses were measured out of their specific blister solution using Non-Invasive Keratograph Drying-Up Time procedure to determine short-term dewetting characteristics. In vitro dewetting characteristic curves of same CL materials soaked in saline solution (control solution) and artificial tear solution (ATS) were measured to determine additional dewetting characteristics.
Materials: Non-Invasive Keratograph Drying-Up Time was measured for six different CL materials including Nelfilcon A, Delefilcon A, Senofilcon A, Stenfilcon A, Somofilcon A and Narafilcon A out of their specific blister solution, out of saline and out of ATS. For soaking the lenses in saline or ATS, all lenses were rinsed with saline to remove blister solution. 20 lenses of each solution/ material combination were measured. In vitro dewetting behavior of these lenses over 180 seconds was determined and expressed by area under curve values (AUC).
Results: Fasted dewetting occurred for all materials when measured out of saline solution, indicated by the highest averaged AUC value over all lens materials of 9243,3 ± 38,3. Slower dewetting was detected for all materials when measured out of their specific blister solution 7755,9 ± 37,1 and out of ATS 7988,8 ± 40,0. Intra group results were statistically different (Kruskal-Wallis) with p<0,001 for saline and blister solution. Intra group differences were smaller for ATS but also statistically different p<0,05.
Conclusion: Pure saline solution leads to faster in vitro dewetting for all materials in comparison to their specific blister solution or ATS. In vitro dewetting experiments focused on saline only, may show bigger differences as present in reality. The use of ATS allows to decrease the gap between in vitro and in vivo measurements.
Shows, Amanda; Redfern, Rachel L.; Sickenberger, Wolfgang; Fogt, Jennifer Swingle; Schulze, Marc; Lievens, Christopher; Szczotka-Flynn, Loretta; Schwarz, Stefan; Tichenor, Anna A.; Marx, Sebastian; Lemp-Hull, Jessie M.
Lipid Analysis on Block Copolymer–containing Packaging Solution and Lens Care Regimens: A Randomized Clinical Trial Journal Article
In: Optometry and Vision Science , vol. 97, no. 8, pp. 565-572, 2020.
@article{Shows2020,
title = {Lipid Analysis on Block Copolymer–containing Packaging Solution and Lens Care Regimens: A Randomized Clinical Trial},
author = {Amanda Shows and Rachel L. Redfern and Wolfgang Sickenberger and Jennifer Swingle Fogt and Marc Schulze and Christopher Lievens and Loretta Szczotka-Flynn and Stefan Schwarz and Anna A. Tichenor and Sebastian Marx and Jessie M. Lemp-Hull},
url = {https://journals.lww.com/optvissci/Fulltext/2020/08000/Lipid_Analysis_on_Block_Copolymer_containing.7.aspx},
doi = {10.1097/OPX.0000000000001553 },
year = {2020},
date = {2020-08-01},
urldate = {2020-08-01},
journal = {Optometry and Vision Science },
volume = {97},
number = {8},
pages = {565-572},
abstract = {Abstract
Significance: Lotrafilcon B lenses packaged in and cared for with block copolymer–containing (polyoxyethylene-polyoxybutylene; EOBO) lens care solutions resulted in lower cholesterol extraction than each of the habitual silicone hydrogel lens/multipurpose solution (MPS) regimens tested.
Purpose: This study aimed to compare the extracted cholesterol of lotrafilcon B lenses packaged in and cared for with EOBO-containing lens care solutions with the extracted cholesterol of habitual silicone hydrogel lenses cared for with MPS not containing EOBO.
Methods: In this prospective, randomized, observer-masked parallel study, habitual wearers of senofilcon C, senofilcon A, comfilcon A, and samfilcon A contact lenses using a non-EOBO MPS were randomized 1:1 to lotrafilcon B lenses packaged in and cared for with EOBO-containing solutions or to their habitual lenses and MPS. Subjects randomized to lotrafilcon B were further randomized to one of two EOBO-containing lens care solutions, OPTI-FREE PUREMOIST or CLEAR CARE PLUS with HydraGlyde (Alcon Laboratories, Inc., Fort Worth, TX). A subset of right eye lenses was collected after wear, and total cholesterol was extracted and measured using a fluorometric enzymatic assay.
Results: Of 143 lenses analyzed, 95 were from subjects randomized to their habitual lenses/MPS and 48 to lotrafilcon B + EOBO lenses plus CLEAR CARE PLUS with HydraGlyde or OPTI-FREE PUREMOIST. The mean amounts of cholesterol extracted from lotrafilcon B + EOBO lenses cared for with CLEAR CARE PLUS with HydraGlyde (0.28 ± 0.18 μg/lens) and OPTI-FREE PUREMOIST (0.28 ± 0.48 μg/lens) were significantly lower than those extracted from senofilcon C (4.18 ± 3.25 μg/lens), senofilcon A (2.19 ± 2.69 μg/lens), comfilcon A (2.17 ± 1.47 μg/lens), and samfilcon A (2.07 ± 1.48 μg/lens) lenses used with MPS (P < .0001 each).
Conclusion: Cholesterol sorption was significantly lower in wearers of lotrafilcon B lenses cared for with polyoxyethylene-polyoxybutylene–containing lens care solutions than in users of habitual silicone hydrogel lenses cared for with non–polyoxyethylene-polyoxybutylene MPS.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Significance: Lotrafilcon B lenses packaged in and cared for with block copolymer–containing (polyoxyethylene-polyoxybutylene; EOBO) lens care solutions resulted in lower cholesterol extraction than each of the habitual silicone hydrogel lens/multipurpose solution (MPS) regimens tested.
Purpose: This study aimed to compare the extracted cholesterol of lotrafilcon B lenses packaged in and cared for with EOBO-containing lens care solutions with the extracted cholesterol of habitual silicone hydrogel lenses cared for with MPS not containing EOBO.
Methods: In this prospective, randomized, observer-masked parallel study, habitual wearers of senofilcon C, senofilcon A, comfilcon A, and samfilcon A contact lenses using a non-EOBO MPS were randomized 1:1 to lotrafilcon B lenses packaged in and cared for with EOBO-containing solutions or to their habitual lenses and MPS. Subjects randomized to lotrafilcon B were further randomized to one of two EOBO-containing lens care solutions, OPTI-FREE PUREMOIST or CLEAR CARE PLUS with HydraGlyde (Alcon Laboratories, Inc., Fort Worth, TX). A subset of right eye lenses was collected after wear, and total cholesterol was extracted and measured using a fluorometric enzymatic assay.
Results: Of 143 lenses analyzed, 95 were from subjects randomized to their habitual lenses/MPS and 48 to lotrafilcon B + EOBO lenses plus CLEAR CARE PLUS with HydraGlyde or OPTI-FREE PUREMOIST. The mean amounts of cholesterol extracted from lotrafilcon B + EOBO lenses cared for with CLEAR CARE PLUS with HydraGlyde (0.28 ± 0.18 μg/lens) and OPTI-FREE PUREMOIST (0.28 ± 0.48 μg/lens) were significantly lower than those extracted from senofilcon C (4.18 ± 3.25 μg/lens), senofilcon A (2.19 ± 2.69 μg/lens), comfilcon A (2.17 ± 1.47 μg/lens), and samfilcon A (2.07 ± 1.48 μg/lens) lenses used with MPS (P < .0001 each).
Conclusion: Cholesterol sorption was significantly lower in wearers of lotrafilcon B lenses cared for with polyoxyethylene-polyoxybutylene–containing lens care solutions than in users of habitual silicone hydrogel lenses cared for with non–polyoxyethylene-polyoxybutylene MPS.
Significance: Lotrafilcon B lenses packaged in and cared for with block copolymer–containing (polyoxyethylene-polyoxybutylene; EOBO) lens care solutions resulted in lower cholesterol extraction than each of the habitual silicone hydrogel lens/multipurpose solution (MPS) regimens tested.
Purpose: This study aimed to compare the extracted cholesterol of lotrafilcon B lenses packaged in and cared for with EOBO-containing lens care solutions with the extracted cholesterol of habitual silicone hydrogel lenses cared for with MPS not containing EOBO.
Methods: In this prospective, randomized, observer-masked parallel study, habitual wearers of senofilcon C, senofilcon A, comfilcon A, and samfilcon A contact lenses using a non-EOBO MPS were randomized 1:1 to lotrafilcon B lenses packaged in and cared for with EOBO-containing solutions or to their habitual lenses and MPS. Subjects randomized to lotrafilcon B were further randomized to one of two EOBO-containing lens care solutions, OPTI-FREE PUREMOIST or CLEAR CARE PLUS with HydraGlyde (Alcon Laboratories, Inc., Fort Worth, TX). A subset of right eye lenses was collected after wear, and total cholesterol was extracted and measured using a fluorometric enzymatic assay.
Results: Of 143 lenses analyzed, 95 were from subjects randomized to their habitual lenses/MPS and 48 to lotrafilcon B + EOBO lenses plus CLEAR CARE PLUS with HydraGlyde or OPTI-FREE PUREMOIST. The mean amounts of cholesterol extracted from lotrafilcon B + EOBO lenses cared for with CLEAR CARE PLUS with HydraGlyde (0.28 ± 0.18 μg/lens) and OPTI-FREE PUREMOIST (0.28 ± 0.48 μg/lens) were significantly lower than those extracted from senofilcon C (4.18 ± 3.25 μg/lens), senofilcon A (2.19 ± 2.69 μg/lens), comfilcon A (2.17 ± 1.47 μg/lens), and samfilcon A (2.07 ± 1.48 μg/lens) lenses used with MPS (P < .0001 each).
Conclusion: Cholesterol sorption was significantly lower in wearers of lotrafilcon B lenses cared for with polyoxyethylene-polyoxybutylene–containing lens care solutions than in users of habitual silicone hydrogel lenses cared for with non–polyoxyethylene-polyoxybutylene MPS.
Kolbe, Oliver; Zimmermann, Felix; Marx, Sebastian; Sickenberger, Wolfgang
Introducing a novel in vivo method to access visual performance during dewetting process of contact lens surface Journal Article
In: Contact Lens and Anterior Eye, vol. 3, 2020.
@article{Kolbe2020,
title = {Introducing a novel in vivo method to access visual performance during dewetting process of contact lens surface},
author = {Oliver Kolbe and Felix Zimmermann and Sebastian Marx and Wolfgang Sickenberger},
url = {https://www.jenvis-research.com/wp-content/uploads/2020/06/Graphical-Abstract-CLAE.jpg},
doi = {10.1016/j.clae.2020.02.011},
year = {2020},
date = {2020-03-02},
urldate = {2020-03-02},
journal = {Contact Lens and Anterior Eye},
volume = {3},
abstract = {Abstract
Purpose: To introduce a novel in vivo method (Visual Acuity Dry Up; VADU) for testing the visual performance during the dewetting of the pre-lens tear film on a contact lens (CL).
Methods: Thirty-nine subjects were fitted with daily disposable CL (Nelfilcon A). Visual performance and dewetting characteristics of the pre-lens tear film were simultaneously assessed using a modified multifunctional topographer (Keratograph 5 M, OCULUS Optikgeräte GmbH, Wetzlar, GERMANY) and the Non-Invasive Keratograph Dry-Up Time (NIKDUT) method. Measures were taken after five minutes and eight hours of CL wear and included the Visual Acuity Dry-Up Time (VADUT; time between last blink and visual breakdown) and the Visual Acuity Dry-Up Area (VADUA; dewetted CL area at visual breakdown) at one (VA+0.1logMAR), two (VA+0.2logMAR) and three (VA+0.3logMAR) log units below maximal visual acuity (VA).
Results: Participants lost one, two or three log units of VA after 13.1 ± 17.4 s, 20.83 ± 21.81, 34.67 ± 29.11 (VADUT), corresponding to a dewetted CL area of 4.82 ± 6.64 mm², 9.5 ± 8.26 and 13.0 ± 8.68 (VADUA), respectively. Differences in VADUT und VADUA for all visual requirements were significant (all p < 0.05). VADUT and VADUA did not vary with CL wear duration (all p > 0.05). A median VA loss of one log unit occurred five seconds after the first dewetting.
Conclusions: The novel VADU method can be used to analyze the role of the tear film stability on the visual performance during CL wear. Hereby, visual loss is quantified based on the threshold definition of the psychometric function.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Purpose: To introduce a novel in vivo method (Visual Acuity Dry Up; VADU) for testing the visual performance during the dewetting of the pre-lens tear film on a contact lens (CL).
Methods: Thirty-nine subjects were fitted with daily disposable CL (Nelfilcon A). Visual performance and dewetting characteristics of the pre-lens tear film were simultaneously assessed using a modified multifunctional topographer (Keratograph 5 M, OCULUS Optikgeräte GmbH, Wetzlar, GERMANY) and the Non-Invasive Keratograph Dry-Up Time (NIKDUT) method. Measures were taken after five minutes and eight hours of CL wear and included the Visual Acuity Dry-Up Time (VADUT; time between last blink and visual breakdown) and the Visual Acuity Dry-Up Area (VADUA; dewetted CL area at visual breakdown) at one (VA+0.1logMAR), two (VA+0.2logMAR) and three (VA+0.3logMAR) log units below maximal visual acuity (VA).
Results: Participants lost one, two or three log units of VA after 13.1 ± 17.4 s, 20.83 ± 21.81, 34.67 ± 29.11 (VADUT), corresponding to a dewetted CL area of 4.82 ± 6.64 mm², 9.5 ± 8.26 and 13.0 ± 8.68 (VADUA), respectively. Differences in VADUT und VADUA for all visual requirements were significant (all p < 0.05). VADUT and VADUA did not vary with CL wear duration (all p > 0.05). A median VA loss of one log unit occurred five seconds after the first dewetting.
Conclusions: The novel VADU method can be used to analyze the role of the tear film stability on the visual performance during CL wear. Hereby, visual loss is quantified based on the threshold definition of the psychometric function.
Purpose: To introduce a novel in vivo method (Visual Acuity Dry Up; VADU) for testing the visual performance during the dewetting of the pre-lens tear film on a contact lens (CL).
Methods: Thirty-nine subjects were fitted with daily disposable CL (Nelfilcon A). Visual performance and dewetting characteristics of the pre-lens tear film were simultaneously assessed using a modified multifunctional topographer (Keratograph 5 M, OCULUS Optikgeräte GmbH, Wetzlar, GERMANY) and the Non-Invasive Keratograph Dry-Up Time (NIKDUT) method. Measures were taken after five minutes and eight hours of CL wear and included the Visual Acuity Dry-Up Time (VADUT; time between last blink and visual breakdown) and the Visual Acuity Dry-Up Area (VADUA; dewetted CL area at visual breakdown) at one (VA+0.1logMAR), two (VA+0.2logMAR) and three (VA+0.3logMAR) log units below maximal visual acuity (VA).
Results: Participants lost one, two or three log units of VA after 13.1 ± 17.4 s, 20.83 ± 21.81, 34.67 ± 29.11 (VADUT), corresponding to a dewetted CL area of 4.82 ± 6.64 mm², 9.5 ± 8.26 and 13.0 ± 8.68 (VADUA), respectively. Differences in VADUT und VADUA for all visual requirements were significant (all p < 0.05). VADUT and VADUA did not vary with CL wear duration (all p > 0.05). A median VA loss of one log unit occurred five seconds after the first dewetting.
Conclusions: The novel VADU method can be used to analyze the role of the tear film stability on the visual performance during CL wear. Hereby, visual loss is quantified based on the threshold definition of the psychometric function.
Müller, Christiane; Marx, Sebastian; Wittekind, Julia; Sickenberger, Wolfgang
Subjective Comparison of Pre-Lens Tear Film Stability of Daily Disposable Contact Lenses Using Ring Mire Projection Journal Article
In: Clinical Optometry, vol. 2020, no. 12, pp. 17-26, 2020.
@article{Müller2020,
title = {Subjective Comparison of Pre-Lens Tear Film Stability of Daily Disposable Contact Lenses Using Ring Mire Projection},
author = {Christiane Müller and Sebastian Marx and Julia Wittekind and Wolfgang Sickenberger},
url = {https://www.jenvis-research.com/wp-content/uploads/2020/02/opto-235167-subjective-comparison-of-pre-lens-tear-film-stability-of-dai-1.pdf},
doi = {https://doi.org/10.2147/OPTO.S235167},
year = {2020},
date = {2020-02-28},
urldate = {2020-02-28},
journal = {Clinical Optometry},
volume = {2020},
number = {12},
pages = {17-26},
abstract = {Abstract
Purpose: To subjectively evaluate the in vivo tear film stability of three daily disposable contact lenses (DDCLs) using placido ring reflection at lens wear times of 5 mins and 8 and 12 hrs.
Patients and Methods: This prospective, randomized, observer-masked, 3-way crossover study evaluated 28 subjects with good tear film stability. In vivo tear film stability was assessed for three DDCLs (nelfilcon A, etafilcon A, omafilcon A) on three different days over 12 hrs of lens wear. Time to first distortion by non-invasive keratography drying-up time (NIK-DUTf) was assessed by reviewing the captured videos. Lens wettability was also graded subjectively by three investigators using a scale from 0 (no visible distortions) to 3 (distortions in more than one-third of the ring reflection zone). Medians were analyzed statistically.
Results: Mean NIKDUTf at 8 hrs was longer for nelfilcon A and shorter for etafilcon A and omafilcon A, but the differences were not significant. NIK-DUTf did not differ significantly among nelfilcon A, etafilcon A and omafilcon A DDCLs at all visits (p=0.36). Subjective wettability grades after 5 mins, 8 hrs, and 12 hrs differed significantly for etafilcon A (P < 0.01) and omafilcon A (p < 0.01), but not for nelfilcon A (p = 0.05), DDCLs.
Conclusion: Grading was sufficiently sensitive to differentiate the wettability performances of the three lens materials. Nelfilcon A maintained wettability over the wearing period, whereas etafilcon A material showed faster dewetting at 8 and 12 hrs than at 5 mins after lens insertion.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Purpose: To subjectively evaluate the in vivo tear film stability of three daily disposable contact lenses (DDCLs) using placido ring reflection at lens wear times of 5 mins and 8 and 12 hrs.
Patients and Methods: This prospective, randomized, observer-masked, 3-way crossover study evaluated 28 subjects with good tear film stability. In vivo tear film stability was assessed for three DDCLs (nelfilcon A, etafilcon A, omafilcon A) on three different days over 12 hrs of lens wear. Time to first distortion by non-invasive keratography drying-up time (NIK-DUTf) was assessed by reviewing the captured videos. Lens wettability was also graded subjectively by three investigators using a scale from 0 (no visible distortions) to 3 (distortions in more than one-third of the ring reflection zone). Medians were analyzed statistically.
Results: Mean NIKDUTf at 8 hrs was longer for nelfilcon A and shorter for etafilcon A and omafilcon A, but the differences were not significant. NIK-DUTf did not differ significantly among nelfilcon A, etafilcon A and omafilcon A DDCLs at all visits (p=0.36). Subjective wettability grades after 5 mins, 8 hrs, and 12 hrs differed significantly for etafilcon A (P < 0.01) and omafilcon A (p < 0.01), but not for nelfilcon A (p = 0.05), DDCLs.
Conclusion: Grading was sufficiently sensitive to differentiate the wettability performances of the three lens materials. Nelfilcon A maintained wettability over the wearing period, whereas etafilcon A material showed faster dewetting at 8 and 12 hrs than at 5 mins after lens insertion.
Purpose: To subjectively evaluate the in vivo tear film stability of three daily disposable contact lenses (DDCLs) using placido ring reflection at lens wear times of 5 mins and 8 and 12 hrs.
Patients and Methods: This prospective, randomized, observer-masked, 3-way crossover study evaluated 28 subjects with good tear film stability. In vivo tear film stability was assessed for three DDCLs (nelfilcon A, etafilcon A, omafilcon A) on three different days over 12 hrs of lens wear. Time to first distortion by non-invasive keratography drying-up time (NIK-DUTf) was assessed by reviewing the captured videos. Lens wettability was also graded subjectively by three investigators using a scale from 0 (no visible distortions) to 3 (distortions in more than one-third of the ring reflection zone). Medians were analyzed statistically.
Results: Mean NIKDUTf at 8 hrs was longer for nelfilcon A and shorter for etafilcon A and omafilcon A, but the differences were not significant. NIK-DUTf did not differ significantly among nelfilcon A, etafilcon A and omafilcon A DDCLs at all visits (p=0.36). Subjective wettability grades after 5 mins, 8 hrs, and 12 hrs differed significantly for etafilcon A (P < 0.01) and omafilcon A (p < 0.01), but not for nelfilcon A (p = 0.05), DDCLs.
Conclusion: Grading was sufficiently sensitive to differentiate the wettability performances of the three lens materials. Nelfilcon A maintained wettability over the wearing period, whereas etafilcon A material showed faster dewetting at 8 and 12 hrs than at 5 mins after lens insertion.
2019
Fuchs, Luise; Schubert, Sebastian; Marx, Sebastian; Sickenberger, Wolfgang
Inflammatory Enzyme MMP-9 in Tear Film of Contact Lens Wearers Conference
American Academy of Optometry 2019.
@conference{Fuchs2019,
title = {Inflammatory Enzyme MMP-9 in Tear Film of Contact Lens Wearers},
author = {Luise Fuchs and Sebastian Schubert and Sebastian Marx and Wolfgang Sickenberger},
url = {https://www.researchgate.net/publication/337008316_Inflammatory_Enzyme_MMP-9_in_Tear_Film_of_Contact_Lens_Wearers},
doi = {10.13140/RG.2.2.34289.02404},
year = {2019},
date = {2019-10-25},
urldate = {2019-10-25},
organization = {American Academy of Optometry},
abstract = {Abstract
Purpose: Inflammation and CL wear is still under discussion. Especially the question which CL material and wearing modality leads to higher numbers of inflammation. Primary aim of this study was to measure if pro-inflammatory enzyme MMP-9 is found in the tear film of wearers of both material categories - soft and rigid contact lenses. The secondary objective was to asses if MMP-9 findings are present in subjects with and without dry eye symptoms.
Methods: An explorative matched study design was used to investigate the impact of soft and rigid materials in CL wearers regarding the MMP-9 findings. A total of 60 randomly selected contact lens wearers (30 wearers of soft contact lens vs. 30 wearers of rigid contact lenses) fullfilled the inclusion criteria. The distribution of gender and age groups were evenly matched in both groups. To determine the grade of signs and symptoms, a slit lamp investigation, a subjective Dry Eye Questionnaire (MCMONNIES) and a questionnaire about wearing behavior of the contact lenses and lifestyle habits of the subjects were evaluated. Finally, the presence of MMP-9 was examined in the tear film using a screening test (InflammaDry, Quidel Corporation).
Results: 36.7% of MMP-9 tests were positive within the SCL group whereas 23.3% of all MMP-9 tests were positive in the RGP group. 31 subjects did not show signs and symptoms of dry eye. Within this subgroup 77.4% of InflammaDry-Tests were negative and 22.6% positive. Among the other 29 subjects at least minimal signs and symptoms were detected. InflammaDry results in this symptomatic subgroup were 37.9% positive and 62.1% negative.
Conclusion: The results show that SCL wear leads to a 1.6x increased risk of positive MMP-9 findings. However, more than 20% of positive MMP-9 findings were not clinically relevant. This study cannot fully answer the question if CL wear can primarily increase the MMP-9 level, as side effects of contact lens wear may also contribute to an increased MMP-9 value. The work serves as the basis for further investigations.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: Inflammation and CL wear is still under discussion. Especially the question which CL material and wearing modality leads to higher numbers of inflammation. Primary aim of this study was to measure if pro-inflammatory enzyme MMP-9 is found in the tear film of wearers of both material categories - soft and rigid contact lenses. The secondary objective was to asses if MMP-9 findings are present in subjects with and without dry eye symptoms.
Methods: An explorative matched study design was used to investigate the impact of soft and rigid materials in CL wearers regarding the MMP-9 findings. A total of 60 randomly selected contact lens wearers (30 wearers of soft contact lens vs. 30 wearers of rigid contact lenses) fullfilled the inclusion criteria. The distribution of gender and age groups were evenly matched in both groups. To determine the grade of signs and symptoms, a slit lamp investigation, a subjective Dry Eye Questionnaire (MCMONNIES) and a questionnaire about wearing behavior of the contact lenses and lifestyle habits of the subjects were evaluated. Finally, the presence of MMP-9 was examined in the tear film using a screening test (InflammaDry, Quidel Corporation).
Results: 36.7% of MMP-9 tests were positive within the SCL group whereas 23.3% of all MMP-9 tests were positive in the RGP group. 31 subjects did not show signs and symptoms of dry eye. Within this subgroup 77.4% of InflammaDry-Tests were negative and 22.6% positive. Among the other 29 subjects at least minimal signs and symptoms were detected. InflammaDry results in this symptomatic subgroup were 37.9% positive and 62.1% negative.
Conclusion: The results show that SCL wear leads to a 1.6x increased risk of positive MMP-9 findings. However, more than 20% of positive MMP-9 findings were not clinically relevant. This study cannot fully answer the question if CL wear can primarily increase the MMP-9 level, as side effects of contact lens wear may also contribute to an increased MMP-9 value. The work serves as the basis for further investigations.
Purpose: Inflammation and CL wear is still under discussion. Especially the question which CL material and wearing modality leads to higher numbers of inflammation. Primary aim of this study was to measure if pro-inflammatory enzyme MMP-9 is found in the tear film of wearers of both material categories - soft and rigid contact lenses. The secondary objective was to asses if MMP-9 findings are present in subjects with and without dry eye symptoms.
Methods: An explorative matched study design was used to investigate the impact of soft and rigid materials in CL wearers regarding the MMP-9 findings. A total of 60 randomly selected contact lens wearers (30 wearers of soft contact lens vs. 30 wearers of rigid contact lenses) fullfilled the inclusion criteria. The distribution of gender and age groups were evenly matched in both groups. To determine the grade of signs and symptoms, a slit lamp investigation, a subjective Dry Eye Questionnaire (MCMONNIES) and a questionnaire about wearing behavior of the contact lenses and lifestyle habits of the subjects were evaluated. Finally, the presence of MMP-9 was examined in the tear film using a screening test (InflammaDry, Quidel Corporation).
Results: 36.7% of MMP-9 tests were positive within the SCL group whereas 23.3% of all MMP-9 tests were positive in the RGP group. 31 subjects did not show signs and symptoms of dry eye. Within this subgroup 77.4% of InflammaDry-Tests were negative and 22.6% positive. Among the other 29 subjects at least minimal signs and symptoms were detected. InflammaDry results in this symptomatic subgroup were 37.9% positive and 62.1% negative.
Conclusion: The results show that SCL wear leads to a 1.6x increased risk of positive MMP-9 findings. However, more than 20% of positive MMP-9 findings were not clinically relevant. This study cannot fully answer the question if CL wear can primarily increase the MMP-9 level, as side effects of contact lens wear may also contribute to an increased MMP-9 value. The work serves as the basis for further investigations.
Kapfelsberger, Andrea; Marx, Sebastian; Sickenberger, Wolfgang; Bischoff, Jürgen
Measurement of the UV and VIS transmittance of soft contact lenses with & without UV-Blocker Conference
American Academy of Optometry 2019.
@conference{Kapfelsberger2019,
title = {Measurement of the UV and VIS transmittance of soft contact lenses with & without UV-Blocker},
author = {Andrea Kapfelsberger and Sebastian Marx and Wolfgang Sickenberger and Jürgen Bischoff},
url = {https://www.jenvis-research.com/wp-content/uploads/2019/11/AAO-2019-Poster-final-print-version__NEU.pdf},
doi = {10.13140/RG.2.2.10748.49283},
year = {2019},
date = {2019-10-25},
urldate = {2019-10-25},
organization = {American Academy of Optometry},
abstract = {Abstract
Purpose: Primary objective was to determine the UV- and VIS light transmittance of different soft, commercially available contact lenses with and without UV filters in respect to their BVP. Materials and
Methods: 21 different lens brands were investigated in the BVP range of -12.00 D to +6.00 D in 1.00 D steps. Three contact lenses were measured per lens power 25 times. These were 339 contact lenses with UV-filter (Stenfilcon A, Somofilcon A, Narafilcon A, Seno-filcon A, Senofilcon C, Etafilcon A, Nesofilcon A) and 489 contact lenses without UV-filter (Dele-filcon A, Lotrafilcon A, Lotrafilcon B, Comfilcon A, Balafilcon A, Samfilcon A, Asmofilcon A, Nel-filcon A, Omafilcon A, Hilafilcon B, Ocufilcon D, Hioxifilcon A, Omafilcon B). The setup for the measurement of the spectral transmittance was created according to EN ISO 18369-3 and consisted of a 75W xenon lamp XH-100 (MÜLLER ELEKTRONIK), a grating spec-trometer SPECTRO 100 (INSTRUMENT SYSTEMS), a wett cell (JENVIS RESEARCH) and a integrating Ulbricht sphere which is necessary to eliminate the scattering or focusing effect of the contact lenses.
Results: All 339 UV-absorbing test contact lenses meet at least UV protection class 2, i.e. they absorb more than 50 % UV-A radiation and more than 95 % UV-B radiation. The contact lenses made of Senofilcon A, Senofilcon C and Narafilcon A meet UV protection class 1 (absorption: UV-A > 90 %, UV-B > 99 %). A statistically significant difference in UV transmittance (280 to 380 nm) could be observed be-tween the test lenses of increased thickness (+1.00 D to +6.00 D) and the lenses of lower thick-ness (-1.00 D to -12.00 D), both without (p1=0.043) and with UV filter (p2=0.018). An additional post-hoc power analysis shows that the study reveals this difference with a probability of 41 % and 50.4 %, respectively. The comparison of the UV transmittance of contact lenses with UV filter within the minus lenses (-12.00 D to -1.00 D) and within the plus lenses (+6.00 D to +1.00 D) showed no statistically sig-nificant difference.
Conclusion: With the ISO conform diopter-independent measurement setup it can be shown that all UV-absorbing test contact lenses meet the current international standards regardless of their BVP. It can be shown that lenses with increased center thickness absorb more UV light. Further studies may investigate differences regarding lens powers with minus lenses, which would require an aperture of the measurement setup larger than 6.0 mm in order to take a closer look to the UV absorption of the lenses in the complete corneal area.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: Primary objective was to determine the UV- and VIS light transmittance of different soft, commercially available contact lenses with and without UV filters in respect to their BVP. Materials and
Methods: 21 different lens brands were investigated in the BVP range of -12.00 D to +6.00 D in 1.00 D steps. Three contact lenses were measured per lens power 25 times. These were 339 contact lenses with UV-filter (Stenfilcon A, Somofilcon A, Narafilcon A, Seno-filcon A, Senofilcon C, Etafilcon A, Nesofilcon A) and 489 contact lenses without UV-filter (Dele-filcon A, Lotrafilcon A, Lotrafilcon B, Comfilcon A, Balafilcon A, Samfilcon A, Asmofilcon A, Nel-filcon A, Omafilcon A, Hilafilcon B, Ocufilcon D, Hioxifilcon A, Omafilcon B). The setup for the measurement of the spectral transmittance was created according to EN ISO 18369-3 and consisted of a 75W xenon lamp XH-100 (MÜLLER ELEKTRONIK), a grating spec-trometer SPECTRO 100 (INSTRUMENT SYSTEMS), a wett cell (JENVIS RESEARCH) and a integrating Ulbricht sphere which is necessary to eliminate the scattering or focusing effect of the contact lenses.
Results: All 339 UV-absorbing test contact lenses meet at least UV protection class 2, i.e. they absorb more than 50 % UV-A radiation and more than 95 % UV-B radiation. The contact lenses made of Senofilcon A, Senofilcon C and Narafilcon A meet UV protection class 1 (absorption: UV-A > 90 %, UV-B > 99 %). A statistically significant difference in UV transmittance (280 to 380 nm) could be observed be-tween the test lenses of increased thickness (+1.00 D to +6.00 D) and the lenses of lower thick-ness (-1.00 D to -12.00 D), both without (p1=0.043) and with UV filter (p2=0.018). An additional post-hoc power analysis shows that the study reveals this difference with a probability of 41 % and 50.4 %, respectively. The comparison of the UV transmittance of contact lenses with UV filter within the minus lenses (-12.00 D to -1.00 D) and within the plus lenses (+6.00 D to +1.00 D) showed no statistically sig-nificant difference.
Conclusion: With the ISO conform diopter-independent measurement setup it can be shown that all UV-absorbing test contact lenses meet the current international standards regardless of their BVP. It can be shown that lenses with increased center thickness absorb more UV light. Further studies may investigate differences regarding lens powers with minus lenses, which would require an aperture of the measurement setup larger than 6.0 mm in order to take a closer look to the UV absorption of the lenses in the complete corneal area.
Purpose: Primary objective was to determine the UV- and VIS light transmittance of different soft, commercially available contact lenses with and without UV filters in respect to their BVP. Materials and
Methods: 21 different lens brands were investigated in the BVP range of -12.00 D to +6.00 D in 1.00 D steps. Three contact lenses were measured per lens power 25 times. These were 339 contact lenses with UV-filter (Stenfilcon A, Somofilcon A, Narafilcon A, Seno-filcon A, Senofilcon C, Etafilcon A, Nesofilcon A) and 489 contact lenses without UV-filter (Dele-filcon A, Lotrafilcon A, Lotrafilcon B, Comfilcon A, Balafilcon A, Samfilcon A, Asmofilcon A, Nel-filcon A, Omafilcon A, Hilafilcon B, Ocufilcon D, Hioxifilcon A, Omafilcon B). The setup for the measurement of the spectral transmittance was created according to EN ISO 18369-3 and consisted of a 75W xenon lamp XH-100 (MÜLLER ELEKTRONIK), a grating spec-trometer SPECTRO 100 (INSTRUMENT SYSTEMS), a wett cell (JENVIS RESEARCH) and a integrating Ulbricht sphere which is necessary to eliminate the scattering or focusing effect of the contact lenses.
Results: All 339 UV-absorbing test contact lenses meet at least UV protection class 2, i.e. they absorb more than 50 % UV-A radiation and more than 95 % UV-B radiation. The contact lenses made of Senofilcon A, Senofilcon C and Narafilcon A meet UV protection class 1 (absorption: UV-A > 90 %, UV-B > 99 %). A statistically significant difference in UV transmittance (280 to 380 nm) could be observed be-tween the test lenses of increased thickness (+1.00 D to +6.00 D) and the lenses of lower thick-ness (-1.00 D to -12.00 D), both without (p1=0.043) and with UV filter (p2=0.018). An additional post-hoc power analysis shows that the study reveals this difference with a probability of 41 % and 50.4 %, respectively. The comparison of the UV transmittance of contact lenses with UV filter within the minus lenses (-12.00 D to -1.00 D) and within the plus lenses (+6.00 D to +1.00 D) showed no statistically sig-nificant difference.
Conclusion: With the ISO conform diopter-independent measurement setup it can be shown that all UV-absorbing test contact lenses meet the current international standards regardless of their BVP. It can be shown that lenses with increased center thickness absorb more UV light. Further studies may investigate differences regarding lens powers with minus lenses, which would require an aperture of the measurement setup larger than 6.0 mm in order to take a closer look to the UV absorption of the lenses in the complete corneal area.
Marx, Sebastian; Zimmermann, Felix; Wittekind, Julia; Sickenberger, Wolfgang
A Novel in vivo Method to Assess Visual Performance during Dewetting Process of Soft Contact Lenses Conference
American Academy of Optometry 2019.
@conference{Marx2019b,
title = {A Novel in vivo Method to Assess Visual Performance during Dewetting Process of Soft Contact Lenses},
author = {Sebastian Marx and Felix Zimmermann and Julia Wittekind and Wolfgang Sickenberger},
url = {https://www.researchgate.net/publication/337534020_A_Novel_in_vivo_Method_to_Assess_Visual_Performance_during_Dewetting_Process_of_Soft_Contact_Lenses},
year = {2019},
date = {2019-10-24},
urldate = {2019-10-24},
organization = {American Academy of Optometry},
abstract = {Abstract
Purpose: To develop a novel in vivo method to assess visual performance (VP) during dewetting process of soft contact lenses and to simultaneously investigate the influence of the drying up behavior of the pre lens tear film (PLTF) on the VP for different optotype sizes.
Methods: Oculus Keratograph 5M was modified with a microscreen to display Landolt-C optotypes and the dewetting characteristics of the PLTF could be simultaneously recorded using the in-built Non-Invasive Keratograph Dry Up Time (NIK-DUT) method. Thirty nine subjects were fitted with nelfilcon A lens material and the subjects underwent dewetting assessment while they responded to the orientation of Landolt-C using a remote controlled device. Recorded videos were analyzed to determine the elapsed time in seconds (Visual Acuity Drying Up Time; VADUT) and dewetted area in mm² (Visual Acuity Drying Up Area; VADUA) at visual loss of one and two log units below maximal distance corrected visual acuity (DCVA). Both VADUT and VADUA were analyzed at the time point after 8 hours of lens wear.
Results: After 13.5 ± 23.0 s and 20.2 ± 24.5 s (VADUT mean ± SD) participants lost one (DCVA+0.1logMAR) and two (DCVA+0.2logMAR) log units of DCVA that corresponded to a mean dewetting area of 5.25 ± 8.99 mm² and 11.17 ± 11.01 mm² (VADUA) of CL surface. VADUT and VADUA were statistically significantly different for one and two log units below DCVA with an alpha level of 0.05 (VADUT: DCVA+0.1logMAR vs DCVA+0.2logMAR P = 0.145; VADUA: DCVA+0.1logMAR vs DCVA+0.2logMAR P < 0.0001).
Conclusions: A novel method to simultaneously determine visual performance and dewetting process of contact lens surface has been optimized. The novel VADU method uses a quantified visual loss of a predefined visual requirement based on the threshold definition of psychometric function to analyze the function of the tear film stability on the VP with contact lens. VP is impacted as a function of the amount of dewetted area of a CL surface and the elapsed time.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: To develop a novel in vivo method to assess visual performance (VP) during dewetting process of soft contact lenses and to simultaneously investigate the influence of the drying up behavior of the pre lens tear film (PLTF) on the VP for different optotype sizes.
Methods: Oculus Keratograph 5M was modified with a microscreen to display Landolt-C optotypes and the dewetting characteristics of the PLTF could be simultaneously recorded using the in-built Non-Invasive Keratograph Dry Up Time (NIK-DUT) method. Thirty nine subjects were fitted with nelfilcon A lens material and the subjects underwent dewetting assessment while they responded to the orientation of Landolt-C using a remote controlled device. Recorded videos were analyzed to determine the elapsed time in seconds (Visual Acuity Drying Up Time; VADUT) and dewetted area in mm² (Visual Acuity Drying Up Area; VADUA) at visual loss of one and two log units below maximal distance corrected visual acuity (DCVA). Both VADUT and VADUA were analyzed at the time point after 8 hours of lens wear.
Results: After 13.5 ± 23.0 s and 20.2 ± 24.5 s (VADUT mean ± SD) participants lost one (DCVA+0.1logMAR) and two (DCVA+0.2logMAR) log units of DCVA that corresponded to a mean dewetting area of 5.25 ± 8.99 mm² and 11.17 ± 11.01 mm² (VADUA) of CL surface. VADUT and VADUA were statistically significantly different for one and two log units below DCVA with an alpha level of 0.05 (VADUT: DCVA+0.1logMAR vs DCVA+0.2logMAR P = 0.145; VADUA: DCVA+0.1logMAR vs DCVA+0.2logMAR P < 0.0001).
Conclusions: A novel method to simultaneously determine visual performance and dewetting process of contact lens surface has been optimized. The novel VADU method uses a quantified visual loss of a predefined visual requirement based on the threshold definition of psychometric function to analyze the function of the tear film stability on the VP with contact lens. VP is impacted as a function of the amount of dewetted area of a CL surface and the elapsed time.
Purpose: To develop a novel in vivo method to assess visual performance (VP) during dewetting process of soft contact lenses and to simultaneously investigate the influence of the drying up behavior of the pre lens tear film (PLTF) on the VP for different optotype sizes.
Methods: Oculus Keratograph 5M was modified with a microscreen to display Landolt-C optotypes and the dewetting characteristics of the PLTF could be simultaneously recorded using the in-built Non-Invasive Keratograph Dry Up Time (NIK-DUT) method. Thirty nine subjects were fitted with nelfilcon A lens material and the subjects underwent dewetting assessment while they responded to the orientation of Landolt-C using a remote controlled device. Recorded videos were analyzed to determine the elapsed time in seconds (Visual Acuity Drying Up Time; VADUT) and dewetted area in mm² (Visual Acuity Drying Up Area; VADUA) at visual loss of one and two log units below maximal distance corrected visual acuity (DCVA). Both VADUT and VADUA were analyzed at the time point after 8 hours of lens wear.
Results: After 13.5 ± 23.0 s and 20.2 ± 24.5 s (VADUT mean ± SD) participants lost one (DCVA+0.1logMAR) and two (DCVA+0.2logMAR) log units of DCVA that corresponded to a mean dewetting area of 5.25 ± 8.99 mm² and 11.17 ± 11.01 mm² (VADUA) of CL surface. VADUT and VADUA were statistically significantly different for one and two log units below DCVA with an alpha level of 0.05 (VADUT: DCVA+0.1logMAR vs DCVA+0.2logMAR P = 0.145; VADUA: DCVA+0.1logMAR vs DCVA+0.2logMAR P < 0.0001).
Conclusions: A novel method to simultaneously determine visual performance and dewetting process of contact lens surface has been optimized. The novel VADU method uses a quantified visual loss of a predefined visual requirement based on the threshold definition of psychometric function to analyze the function of the tear film stability on the VP with contact lens. VP is impacted as a function of the amount of dewetted area of a CL surface and the elapsed time.
Zimmermann, Felix; Kolbe, Oliver; Marx, Sebastian; Sickenberger, Wolfgang
British Contact Lens Association (BCLA) 2019.
@conference{Zimmermann2019,
title = {Introducing a novel in vivo method to access visual performance during dewetting process of contact lens surface},
author = {Felix Zimmermann and Oliver Kolbe and Sebastian Marx and Wolfgang Sickenberger },
url = {https://www.bcla.org.uk/common/Uploaded%20files/Conference%20Materials/Free%20papers%20abstracts.pdf},
year = {2019},
date = {2019-05-30},
urldate = {2019-05-30},
organization = {British Contact Lens Association (BCLA)},
abstract = {Abstract
Purpose: To introduce a novel in vivo method to access visual performance (VP) during dewetting process (Visual Acuity Dry Up; VADU) and investigate the influence of drying up behavior of pre lens tear film (PLTF) on VP for various visual requirements for a daily disposable contact lens (CL) (Nelfilcon A).
Methods: Thirty nine subjects were fitted with CL (Nelfilcon A). Dewetting characteristics of PLTF were recorded by using a modified multifunctional topographer (Keratograph 5M, OCULUS Optikgeräte GmbH, Wetzlar, GERMANY) combined with Non-Invasive Keratograph Dry Up Time (NIK-DUT) method during the assessment of participants VP and blink suppression. Recorded videos were analyzed regarding elapsed time in s (Visual Acuity Drying Up Time; VADUT) and dewetted area in mm2 (Visual Acuity Drying Up Area; VADUA) at visual loss of one, two or three log units below maximal distance corrected visual acuity (DCVA).
Results: After 13.1s±17.4s, 20.83s±21.81s, 34.67s±29.11s (VADUT mean) participants lost one (DCVA+0.1logMAR), two (DCVA+0.2logMAR) or three (DCVA+0.3logMAR) log units of DCVA that corresponds to a mean dewetting area of 4.82mm²±6.64mm², 9.5mm²±8.26mm² and 13.0mm²± 8.68mm² (VADUA) of CL surface. All differences of VADUT und VADUA regarding the visual
requirements (one, two and three log units below DCVA) are statistically significant with an alpha level of 0.05 (VADUT: DCVA+0.1logMAR vs DCVA+0.2logMAR P = 0.006, DCVA+0.1logMAR vs DCVA+0.3logMAR P < 0.0001, DCVA+0.2logMAR vs DCVA+0.3logMAR P = 0.001; VADUA: DCVA+0.1logMAR vs DCVA+0.2logMAR P < 0.0001, DCVA+0.1logMAR vs DCVA+0.3logMAR P < 0.0001, DCVA+0.2logMAR vs DCVA+0.3logMAR P = 0.31).
Conclusion: The novel VADU method uses a quantified visual loss of a predefined visual requirement based on the threshold definition of the psychometric function to analyze the function of PLTF on VP. VP is impacted as a function of the amount of dewetted area of a CL surface and elapsed time. The whole front surface of the cornea may affect the VP.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: To introduce a novel in vivo method to access visual performance (VP) during dewetting process (Visual Acuity Dry Up; VADU) and investigate the influence of drying up behavior of pre lens tear film (PLTF) on VP for various visual requirements for a daily disposable contact lens (CL) (Nelfilcon A).
Methods: Thirty nine subjects were fitted with CL (Nelfilcon A). Dewetting characteristics of PLTF were recorded by using a modified multifunctional topographer (Keratograph 5M, OCULUS Optikgeräte GmbH, Wetzlar, GERMANY) combined with Non-Invasive Keratograph Dry Up Time (NIK-DUT) method during the assessment of participants VP and blink suppression. Recorded videos were analyzed regarding elapsed time in s (Visual Acuity Drying Up Time; VADUT) and dewetted area in mm2 (Visual Acuity Drying Up Area; VADUA) at visual loss of one, two or three log units below maximal distance corrected visual acuity (DCVA).
Results: After 13.1s±17.4s, 20.83s±21.81s, 34.67s±29.11s (VADUT mean) participants lost one (DCVA+0.1logMAR), two (DCVA+0.2logMAR) or three (DCVA+0.3logMAR) log units of DCVA that corresponds to a mean dewetting area of 4.82mm²±6.64mm², 9.5mm²±8.26mm² and 13.0mm²± 8.68mm² (VADUA) of CL surface. All differences of VADUT und VADUA regarding the visual
requirements (one, two and three log units below DCVA) are statistically significant with an alpha level of 0.05 (VADUT: DCVA+0.1logMAR vs DCVA+0.2logMAR P = 0.006, DCVA+0.1logMAR vs DCVA+0.3logMAR P < 0.0001, DCVA+0.2logMAR vs DCVA+0.3logMAR P = 0.001; VADUA: DCVA+0.1logMAR vs DCVA+0.2logMAR P < 0.0001, DCVA+0.1logMAR vs DCVA+0.3logMAR P < 0.0001, DCVA+0.2logMAR vs DCVA+0.3logMAR P = 0.31).
Conclusion: The novel VADU method uses a quantified visual loss of a predefined visual requirement based on the threshold definition of the psychometric function to analyze the function of PLTF on VP. VP is impacted as a function of the amount of dewetted area of a CL surface and elapsed time. The whole front surface of the cornea may affect the VP.
Purpose: To introduce a novel in vivo method to access visual performance (VP) during dewetting process (Visual Acuity Dry Up; VADU) and investigate the influence of drying up behavior of pre lens tear film (PLTF) on VP for various visual requirements for a daily disposable contact lens (CL) (Nelfilcon A).
Methods: Thirty nine subjects were fitted with CL (Nelfilcon A). Dewetting characteristics of PLTF were recorded by using a modified multifunctional topographer (Keratograph 5M, OCULUS Optikgeräte GmbH, Wetzlar, GERMANY) combined with Non-Invasive Keratograph Dry Up Time (NIK-DUT) method during the assessment of participants VP and blink suppression. Recorded videos were analyzed regarding elapsed time in s (Visual Acuity Drying Up Time; VADUT) and dewetted area in mm2 (Visual Acuity Drying Up Area; VADUA) at visual loss of one, two or three log units below maximal distance corrected visual acuity (DCVA).
Results: After 13.1s±17.4s, 20.83s±21.81s, 34.67s±29.11s (VADUT mean) participants lost one (DCVA+0.1logMAR), two (DCVA+0.2logMAR) or three (DCVA+0.3logMAR) log units of DCVA that corresponds to a mean dewetting area of 4.82mm²±6.64mm², 9.5mm²±8.26mm² and 13.0mm²± 8.68mm² (VADUA) of CL surface. All differences of VADUT und VADUA regarding the visual
requirements (one, two and three log units below DCVA) are statistically significant with an alpha level of 0.05 (VADUT: DCVA+0.1logMAR vs DCVA+0.2logMAR P = 0.006, DCVA+0.1logMAR vs DCVA+0.3logMAR P < 0.0001, DCVA+0.2logMAR vs DCVA+0.3logMAR P = 0.001; VADUA: DCVA+0.1logMAR vs DCVA+0.2logMAR P < 0.0001, DCVA+0.1logMAR vs DCVA+0.3logMAR P < 0.0001, DCVA+0.2logMAR vs DCVA+0.3logMAR P = 0.31).
Conclusion: The novel VADU method uses a quantified visual loss of a predefined visual requirement based on the threshold definition of the psychometric function to analyze the function of PLTF on VP. VP is impacted as a function of the amount of dewetted area of a CL surface and elapsed time. The whole front surface of the cornea may affect the VP.
Marx, Sebastian; Zimmermann, Felix; Wittekind, Julia; Sickenberger, Wolfgang
British Contact Lens Association (BCLA) 2019.
@conference{Marx2019,
title = {Dewetting of different soft lens materials before and after stress test with lipid containing rewetting eye drops using Non-Invasive Keratograph Drying Up Time (NIK-DUT)},
author = {Sebastian Marx and Felix Zimmermann and Julia Wittekind and Wolfgang Sickenberger},
url = {https://www.researchgate.net/publication/333866868_Dewetting_of_different_soft_lens_materials_before_and_after_stress_test_with_lipid_containing_rewetting_eye_drops_using_Non-Invasive_Keratograph_Drying_Up_Time_NIK-DUT
https://www.bcla.org.uk/common/Uploaded%20files/Conference%20Materials/Free%20papers%20abstracts.pdf
},
doi = {10.13140/RG.2.2.13188.17287},
year = {2019},
date = {2019-05-30},
urldate = {2019-05-30},
organization = {British Contact Lens Association (BCLA)},
abstract = {Abstract
Objective: The primary objective of the study was to determine differences between surface dewetting of SCL materials out of PBS before and after treatment with lipid containing rewetting drops in vitro using a modified corneal topographer K5M (Non-Invasive Keratograph – Drying-Up Time [NIK-DUT]).
Method and Materials: Fifteen lenses of different SCL material classes according to ISO18369 were tested (polymacon, nelfilcon A, ocufilcon D, balafilcon A, somofilcon A, lotrafilcon B). Lenses were rinsed and stored in PBS to minimize the effect of the original blister solution. Single dewetting videos per lens were captured with K5M. Afterwards all lenses were soaked in phospholipid containing rewetting solution for 25 hours. Lenses were gently shaken by an orbital shaker with a frequency of 15 times per minutes, tilting up to 15°. After treatment all lenses were equilibrated again in PBS for at least 30 minutes. Dewetting videos were captured again. In vitro NIK-DUT was determined for a measurement time of 180 s, expressed by Area under Curve (AUC) data.
Results: The AUC results before and after treatment were: polymacon (4870.85 ± 942.74 and 6214.07 ± 932.09; t(14) = -3.959, p = 0.001), nelfilcon A (4688.03 ± 1065.14 and 6959.76 ± 1081.81; t(14) = -6.444, p < 0.001), ocufilcon D (3612.63 ± 875.51 and 7041.97 ± 714.26; t(14) = -11.294, p < 0.001), balafilcon A (4170.37 ± 927.19 and 7385.56 ± 879.84; t(14) = -10.798, p < 0.001), somofilcon A (4284.49 ± 833.80 and 6762.17 ± 1380.15; t(13) = -7.546, p < 0.001) and lotrafilcon B, comfilcon A (4973.30 ± 1249.25 and 7415.65 ± 994.79, t(14) = -12.565, p < 0.001). All differences were statistically significant at a significance level of 0.05.
Conclusion: Lipid containing solutions interact with various SCL materials and lead to increased in vitro dewetting. Accelerated dewetting of lens surfaces may contribute to both, reduced comfort and vision.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Objective: The primary objective of the study was to determine differences between surface dewetting of SCL materials out of PBS before and after treatment with lipid containing rewetting drops in vitro using a modified corneal topographer K5M (Non-Invasive Keratograph – Drying-Up Time [NIK-DUT]).
Method and Materials: Fifteen lenses of different SCL material classes according to ISO18369 were tested (polymacon, nelfilcon A, ocufilcon D, balafilcon A, somofilcon A, lotrafilcon B). Lenses were rinsed and stored in PBS to minimize the effect of the original blister solution. Single dewetting videos per lens were captured with K5M. Afterwards all lenses were soaked in phospholipid containing rewetting solution for 25 hours. Lenses were gently shaken by an orbital shaker with a frequency of 15 times per minutes, tilting up to 15°. After treatment all lenses were equilibrated again in PBS for at least 30 minutes. Dewetting videos were captured again. In vitro NIK-DUT was determined for a measurement time of 180 s, expressed by Area under Curve (AUC) data.
Results: The AUC results before and after treatment were: polymacon (4870.85 ± 942.74 and 6214.07 ± 932.09; t(14) = -3.959, p = 0.001), nelfilcon A (4688.03 ± 1065.14 and 6959.76 ± 1081.81; t(14) = -6.444, p < 0.001), ocufilcon D (3612.63 ± 875.51 and 7041.97 ± 714.26; t(14) = -11.294, p < 0.001), balafilcon A (4170.37 ± 927.19 and 7385.56 ± 879.84; t(14) = -10.798, p < 0.001), somofilcon A (4284.49 ± 833.80 and 6762.17 ± 1380.15; t(13) = -7.546, p < 0.001) and lotrafilcon B, comfilcon A (4973.30 ± 1249.25 and 7415.65 ± 994.79, t(14) = -12.565, p < 0.001). All differences were statistically significant at a significance level of 0.05.
Conclusion: Lipid containing solutions interact with various SCL materials and lead to increased in vitro dewetting. Accelerated dewetting of lens surfaces may contribute to both, reduced comfort and vision.
Objective: The primary objective of the study was to determine differences between surface dewetting of SCL materials out of PBS before and after treatment with lipid containing rewetting drops in vitro using a modified corneal topographer K5M (Non-Invasive Keratograph – Drying-Up Time [NIK-DUT]).
Method and Materials: Fifteen lenses of different SCL material classes according to ISO18369 were tested (polymacon, nelfilcon A, ocufilcon D, balafilcon A, somofilcon A, lotrafilcon B). Lenses were rinsed and stored in PBS to minimize the effect of the original blister solution. Single dewetting videos per lens were captured with K5M. Afterwards all lenses were soaked in phospholipid containing rewetting solution for 25 hours. Lenses were gently shaken by an orbital shaker with a frequency of 15 times per minutes, tilting up to 15°. After treatment all lenses were equilibrated again in PBS for at least 30 minutes. Dewetting videos were captured again. In vitro NIK-DUT was determined for a measurement time of 180 s, expressed by Area under Curve (AUC) data.
Results: The AUC results before and after treatment were: polymacon (4870.85 ± 942.74 and 6214.07 ± 932.09; t(14) = -3.959, p = 0.001), nelfilcon A (4688.03 ± 1065.14 and 6959.76 ± 1081.81; t(14) = -6.444, p < 0.001), ocufilcon D (3612.63 ± 875.51 and 7041.97 ± 714.26; t(14) = -11.294, p < 0.001), balafilcon A (4170.37 ± 927.19 and 7385.56 ± 879.84; t(14) = -10.798, p < 0.001), somofilcon A (4284.49 ± 833.80 and 6762.17 ± 1380.15; t(13) = -7.546, p < 0.001) and lotrafilcon B, comfilcon A (4973.30 ± 1249.25 and 7415.65 ± 994.79, t(14) = -12.565, p < 0.001). All differences were statistically significant at a significance level of 0.05.
Conclusion: Lipid containing solutions interact with various SCL materials and lead to increased in vitro dewetting. Accelerated dewetting of lens surfaces may contribute to both, reduced comfort and vision.
Pucker, Andrew D.; Jones-Jordan, Lisa A.; Kunnen, Carolina M. E.; Marx, Sebastian; Powell, Daniel R.; Kwan, Justin T.; Srinivasan, Sruthi; Sickenberger, Wolfgang; Jones, Lyndon
Impact of meibomian gland width on successful contact lens use Journal Article
In: Contact Lens and Anterior Eye, vol. 42, no. 6, pp. 646-651, 2019.
@article{Puckera01.1,
title = {Impact of meibomian gland width on successful contact lens use},
author = {Andrew D. Pucker and Lisa A. Jones-Jordan and Carolina M.E. Kunnen and Sebastian Marx and Daniel R. Powell and Justin T. Kwan and Sruthi Srinivasan and Wolfgang Sickenberger and Lyndon Jones},
url = {https://www.jenvis-research.com/wp-content/uploads/2019/11/Impact-of-meibomian-gland-width-on-successful-contact-lens-use-5.pdf},
doi = {https://doi.org/10.1016/j.clae.2019.06.004},
year = {2019},
date = {2019-01-12},
urldate = {2019-01-12},
journal = {Contact Lens and Anterior Eye},
volume = {42},
number = {6},
pages = {646-651},
abstract = {Abstract
Purpose: To evaluate meibomian gland (MG) width and determine its impact on successful contact lens (CL) use and ocular health.
Methods: A five-site study was conducted by recruiting 18- to 45-year-old subjects who had dropped out of CLs because of discomfort. CL dropouts were compared to age- and sex-matched successful CL wearers. Right eyes were evaluated for tear break-up time, tear meniscus height, MG expressibility, meibum quality, and meibography. Central MG widths were evaluated with a custom MATLAB program.
Results: CL dropouts (n=56) and successful CL (n=56) wearers had similar grades for upper (p=1.0) and lower (p=0.22) MG atrophy, upper (p=0.07) and lower (p=0.89) MG tortuosity, and upper (p=0.92) and lower (p=0.97) MG widths. Upper eyelid MG widths were narrower than lower eyelid MG widths (p=0.03). Upper and lower MG tortuosity (p < 0.001) and widths (p=0.03) were associated, but not atrophy (p=0.42). Lower eyelid MG widths were associated with MG expressibility (p=0.01), but MG widths were not with any other factors.
Conclusions: Successful CL wear does not appear to be clinically influenced by MG width or other measures of MG structural integrity. Lower eyelid MGs were wider than upper eyelid MGs and narrower lower eyelid MGs were associated with worse MG expressibility, suggesting that narrower MGs may produce abnormal meibum. Data also suggests that MG factors of both eyelids should be evaluated in practice.
},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Purpose: To evaluate meibomian gland (MG) width and determine its impact on successful contact lens (CL) use and ocular health.
Methods: A five-site study was conducted by recruiting 18- to 45-year-old subjects who had dropped out of CLs because of discomfort. CL dropouts were compared to age- and sex-matched successful CL wearers. Right eyes were evaluated for tear break-up time, tear meniscus height, MG expressibility, meibum quality, and meibography. Central MG widths were evaluated with a custom MATLAB program.
Results: CL dropouts (n=56) and successful CL (n=56) wearers had similar grades for upper (p=1.0) and lower (p=0.22) MG atrophy, upper (p=0.07) and lower (p=0.89) MG tortuosity, and upper (p=0.92) and lower (p=0.97) MG widths. Upper eyelid MG widths were narrower than lower eyelid MG widths (p=0.03). Upper and lower MG tortuosity (p < 0.001) and widths (p=0.03) were associated, but not atrophy (p=0.42). Lower eyelid MG widths were associated with MG expressibility (p=0.01), but MG widths were not with any other factors.
Conclusions: Successful CL wear does not appear to be clinically influenced by MG width or other measures of MG structural integrity. Lower eyelid MGs were wider than upper eyelid MGs and narrower lower eyelid MGs were associated with worse MG expressibility, suggesting that narrower MGs may produce abnormal meibum. Data also suggests that MG factors of both eyelids should be evaluated in practice.
Purpose: To evaluate meibomian gland (MG) width and determine its impact on successful contact lens (CL) use and ocular health.
Methods: A five-site study was conducted by recruiting 18- to 45-year-old subjects who had dropped out of CLs because of discomfort. CL dropouts were compared to age- and sex-matched successful CL wearers. Right eyes were evaluated for tear break-up time, tear meniscus height, MG expressibility, meibum quality, and meibography. Central MG widths were evaluated with a custom MATLAB program.
Results: CL dropouts (n=56) and successful CL (n=56) wearers had similar grades for upper (p=1.0) and lower (p=0.22) MG atrophy, upper (p=0.07) and lower (p=0.89) MG tortuosity, and upper (p=0.92) and lower (p=0.97) MG widths. Upper eyelid MG widths were narrower than lower eyelid MG widths (p=0.03). Upper and lower MG tortuosity (p < 0.001) and widths (p=0.03) were associated, but not atrophy (p=0.42). Lower eyelid MG widths were associated with MG expressibility (p=0.01), but MG widths were not with any other factors.
Conclusions: Successful CL wear does not appear to be clinically influenced by MG width or other measures of MG structural integrity. Lower eyelid MGs were wider than upper eyelid MGs and narrower lower eyelid MGs were associated with worse MG expressibility, suggesting that narrower MGs may produce abnormal meibum. Data also suggests that MG factors of both eyelids should be evaluated in practice.
2018
von Ahrentschildt, Anke; Wittekind, Julia; Marx, Sebastian; Sickenberger, Wolfgang
Academy 2018 San Antonio - American Academy of Optometry 2018.
@conference{vonAhrentschildt2018,
title = {Comparative study of two grading scales for the evaluation of IR-Meibography images of the upper and lower eyelid in terms of intra and interrater reliability},
author = {Anke von Ahrentschildt and Julia Wittekind and Sebastian Marx and Wolfgang Sickenberger},
url = {https://www.jenvis-research.com/wp-content/uploads/2018/11/AAO-2018-Comparative-study-of-two-grading-scales-for-the-evaluation-of-IR-Meibography-images-of-the-upper-and-lower-eyelid-in-terms-of-intra-and-interrater-reliability.pdf},
year = {2018},
date = {2018-11-09},
urldate = {2018-11-09},
organization = {Academy 2018 San Antonio - American Academy of Optometry},
abstract = {Abstract
Purpose: Primary goal was to analyse the intra- an interrater reliability of a new illustrative grading scale by JENVIS RESEARCH which was developed in dependence on the MEIBOSCORE of ARITA et al. (2008) to categorise meibomian gland loss. Secondary goal was to do the same for the MEIBOSCORE and further to compare both scales with each other.
Material and Method: For this purpose, 48 trained practitioners independently graded a set of 80 images, 40 of the upper as well as the lower eyelid, with one of two grading scales in an online survey. This procedure was executed four times, twice with both grading scales. To avoid an interference between the evaluation cycles there was a wash out phase of 7 to 14 days and the images were presented in a randomised order. The classification was performed with the well-established grading scale by ARITA et al. (2008) and a new illustrative one by JENVIS RESEARCH in dependence on ARITA et al. (2008). An estimation regarding the level of interrater and intrarater reliability for the two grading scales was achieved using KAPPA statistics (IBM SPSS STATISTICS 22; MICROSOFT EXCEL 2016) and interpreted as followed: KAPPA-Values < 0 (no agreement), 0–0.2 (slight), 0.21–0.4 (fair), 0.41–0.6 (distinct), 0.61–0.8 (substantial), > 0.8 (almost perfect). For a repeated classification by one grader the KAPPA measures the intrarater reliability, whereas a classification by different graders measures the interrater reliability.
Results: At the end of the study the total database consisted of 15,360 individual gradings, 192 for every image. The median for the intrarater KAPPAs of the ARITA scale for all 48 participants is 0.57 (ø CI ± 0.14), which indicates a ‘distinct’ agreement. The values ranged from 0.24 to 0.77. For JENVIS the median is 0.67 (ø CI ± 0.13) and therefore shows a ‘substantial’ agreement with values ranging between 0.43 and 0.85. Furthermore, the intrarater KAPPA was calculated for the images of the upper and lower eyelid separately. The results are like those considering all meibography images (median upper lid: ARITA = 0.59; JENVIS = 0.72; median lower lid: ARITA = 0.56; JENVIS = 0.63) The interrater reliability was calculated with the FLEISS-KAPPA and is 0.43 (95 %-CI: 0.28–0.58) for the ARITA scale and 0.52 (95 %-CI: 0.38–0.67) for the JENVIS scale. Both demonstrate a ‘distinct’ agreement between the classifications of all graders considering all meibography images as well as considering images of the upper and lower eyelid independently (upper lid: ARITA 0.56 [0.4–0.73], JENVIS 0.66 [0.38–0.71]; lower lid: ARITA 0.54 [0.38–0.71], JENVIS 0.59 [0.43–0.75]). All the specified results are statistically significant with a p-value < 0.01.
Conclusion: Both grading scales show a high degree of agreement concerning the repeatability (intrarater reliability) as well as the classification by different graders (interrater reliability). Especially the intrarater reliability was improved employing the illustrative scale by JENVIS RESEARCH. Illustrative scales may be beneficial to practitioners to classify meibomian gland dropout.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: Primary goal was to analyse the intra- an interrater reliability of a new illustrative grading scale by JENVIS RESEARCH which was developed in dependence on the MEIBOSCORE of ARITA et al. (2008) to categorise meibomian gland loss. Secondary goal was to do the same for the MEIBOSCORE and further to compare both scales with each other.
Material and Method: For this purpose, 48 trained practitioners independently graded a set of 80 images, 40 of the upper as well as the lower eyelid, with one of two grading scales in an online survey. This procedure was executed four times, twice with both grading scales. To avoid an interference between the evaluation cycles there was a wash out phase of 7 to 14 days and the images were presented in a randomised order. The classification was performed with the well-established grading scale by ARITA et al. (2008) and a new illustrative one by JENVIS RESEARCH in dependence on ARITA et al. (2008). An estimation regarding the level of interrater and intrarater reliability for the two grading scales was achieved using KAPPA statistics (IBM SPSS STATISTICS 22; MICROSOFT EXCEL 2016) and interpreted as followed: KAPPA-Values < 0 (no agreement), 0–0.2 (slight), 0.21–0.4 (fair), 0.41–0.6 (distinct), 0.61–0.8 (substantial), > 0.8 (almost perfect). For a repeated classification by one grader the KAPPA measures the intrarater reliability, whereas a classification by different graders measures the interrater reliability.
Results: At the end of the study the total database consisted of 15,360 individual gradings, 192 for every image. The median for the intrarater KAPPAs of the ARITA scale for all 48 participants is 0.57 (ø CI ± 0.14), which indicates a ‘distinct’ agreement. The values ranged from 0.24 to 0.77. For JENVIS the median is 0.67 (ø CI ± 0.13) and therefore shows a ‘substantial’ agreement with values ranging between 0.43 and 0.85. Furthermore, the intrarater KAPPA was calculated for the images of the upper and lower eyelid separately. The results are like those considering all meibography images (median upper lid: ARITA = 0.59; JENVIS = 0.72; median lower lid: ARITA = 0.56; JENVIS = 0.63) The interrater reliability was calculated with the FLEISS-KAPPA and is 0.43 (95 %-CI: 0.28–0.58) for the ARITA scale and 0.52 (95 %-CI: 0.38–0.67) for the JENVIS scale. Both demonstrate a ‘distinct’ agreement between the classifications of all graders considering all meibography images as well as considering images of the upper and lower eyelid independently (upper lid: ARITA 0.56 [0.4–0.73], JENVIS 0.66 [0.38–0.71]; lower lid: ARITA 0.54 [0.38–0.71], JENVIS 0.59 [0.43–0.75]). All the specified results are statistically significant with a p-value < 0.01.
Conclusion: Both grading scales show a high degree of agreement concerning the repeatability (intrarater reliability) as well as the classification by different graders (interrater reliability). Especially the intrarater reliability was improved employing the illustrative scale by JENVIS RESEARCH. Illustrative scales may be beneficial to practitioners to classify meibomian gland dropout.
Purpose: Primary goal was to analyse the intra- an interrater reliability of a new illustrative grading scale by JENVIS RESEARCH which was developed in dependence on the MEIBOSCORE of ARITA et al. (2008) to categorise meibomian gland loss. Secondary goal was to do the same for the MEIBOSCORE and further to compare both scales with each other.
Material and Method: For this purpose, 48 trained practitioners independently graded a set of 80 images, 40 of the upper as well as the lower eyelid, with one of two grading scales in an online survey. This procedure was executed four times, twice with both grading scales. To avoid an interference between the evaluation cycles there was a wash out phase of 7 to 14 days and the images were presented in a randomised order. The classification was performed with the well-established grading scale by ARITA et al. (2008) and a new illustrative one by JENVIS RESEARCH in dependence on ARITA et al. (2008). An estimation regarding the level of interrater and intrarater reliability for the two grading scales was achieved using KAPPA statistics (IBM SPSS STATISTICS 22; MICROSOFT EXCEL 2016) and interpreted as followed: KAPPA-Values < 0 (no agreement), 0–0.2 (slight), 0.21–0.4 (fair), 0.41–0.6 (distinct), 0.61–0.8 (substantial), > 0.8 (almost perfect). For a repeated classification by one grader the KAPPA measures the intrarater reliability, whereas a classification by different graders measures the interrater reliability.
Results: At the end of the study the total database consisted of 15,360 individual gradings, 192 for every image. The median for the intrarater KAPPAs of the ARITA scale for all 48 participants is 0.57 (ø CI ± 0.14), which indicates a ‘distinct’ agreement. The values ranged from 0.24 to 0.77. For JENVIS the median is 0.67 (ø CI ± 0.13) and therefore shows a ‘substantial’ agreement with values ranging between 0.43 and 0.85. Furthermore, the intrarater KAPPA was calculated for the images of the upper and lower eyelid separately. The results are like those considering all meibography images (median upper lid: ARITA = 0.59; JENVIS = 0.72; median lower lid: ARITA = 0.56; JENVIS = 0.63) The interrater reliability was calculated with the FLEISS-KAPPA and is 0.43 (95 %-CI: 0.28–0.58) for the ARITA scale and 0.52 (95 %-CI: 0.38–0.67) for the JENVIS scale. Both demonstrate a ‘distinct’ agreement between the classifications of all graders considering all meibography images as well as considering images of the upper and lower eyelid independently (upper lid: ARITA 0.56 [0.4–0.73], JENVIS 0.66 [0.38–0.71]; lower lid: ARITA 0.54 [0.38–0.71], JENVIS 0.59 [0.43–0.75]). All the specified results are statistically significant with a p-value < 0.01.
Conclusion: Both grading scales show a high degree of agreement concerning the repeatability (intrarater reliability) as well as the classification by different graders (interrater reliability). Especially the intrarater reliability was improved employing the illustrative scale by JENVIS RESEARCH. Illustrative scales may be beneficial to practitioners to classify meibomian gland dropout.
Marx, Sebastian; Kwan, Justin; Jones-Jordan, Lisa A.; Powell, Daniel; Srinivasan, Sruthi; Sickenberger, Wolfgang; Jones, Lyndon; Pucker, Andrew
Degree of Maibomian Gland Tortuosity in Successful Soft Contact Lens Wearers and Dropouts Conference
Conference: Academy 2018 San Antonio - American Academy of Optometry 2018.
@conference{Marx2018,
title = {Degree of Maibomian Gland Tortuosity in Successful Soft Contact Lens Wearers and Dropouts},
author = {Sebastian Marx and Justin Kwan and Lisa A. Jones-Jordan and Daniel Powell and Sruthi Srinivasan and Wolfgang Sickenberger and Lyndon Jones and Andrew Pucker
},
url = {https://www.jenvis-research.com/wp-content/uploads/2018/11/AAO-2018-Degree-of-Maibomian-Gland-Tortuosity-in-Successful-Soft-Contact-Lens-Wearers-and-Dropouts.pdf},
doi = {10.13140/RG.2.2.15911.80803},
year = {2018},
date = {2018-11-09},
urldate = {2018-11-09},
organization = {Conference: Academy 2018 San Antonio - American Academy of Optometry},
abstract = {Abstract
Purpose: The etiology of MG tortuosity (deviated glands) is unknown, but it may be caused by chronic terminal duct obstruction or by genetic predisposition. The purpose of this study was to determine if MG tortuosity impacts successful contact lens (CL) wear and if the degree of tortuosity was associated with other signs or symptoms of ocular dryness.
Methods: This five-site case-control study recruited subjects between 18 and 45 years of age. Cases had ceased CL use within the past 6-12 months due to discomfort, while age- and sex-matched controls were able to comfortably wear CLs for ≥8 hours/day for ≥5 days/week. Each subject was administered a study-specific CL questionnaire and a SPEED questionnaire. Clinical testing included non-invasive tear break-up time (NITBUT), tear meniscus height (TMH), MG expressibility, meibum quality, and meibography (OCULUS Keratograph 5M). MG tortuosity for each eyelid was graded using the 5-point Halleran scale (Grade 0: no tortuosity; Grade 4: ≥75% of visible MG being tortuous). Worse eyes (determined by worse eye for tortuosity) comparisons were made with paired t-tests (means) or McNemar’s test (frequencies).
Result: 56 matched-pairs were recruited across sites. The mean ± SD age of the cases (28.5 ± 7.1 years) and controls (28.6 ± 7.0 years) were not significantly different (p = 0.66). MG tortuosity in control subjects with grade 2 or higher tortuosity was seen in 50% of the upper eyelid and 20% in the lower eyelid. The same intensity of MG tortuosity in dropout subjects was detected in 62% of the upper eyelid and 9% in the lower eyelid. The cases had significantly higher SPEED scores than the controls (6.42 ± 4.96 vs. 2.62 ± 2.66; p < 0.001). Cases did not have significantly higher upper (2.13 ± 1.09 vs. 1.80 ± 0.96; p = 0.07), lower (0.82 ± 0.64 vs. 1.00 ± 0.74; p = 0.12) or total (2.97 ± 1.30 vs. 2.80 ± 1.29; p = 0.39) eyelid tortuosity scores than controls. Tortuosity was significantly associated with TMH (p = 0.02), MG expressibility of upper (p = 0.03) and lower eyelids (p = 0.01) but not SPEED, NITBUT, meibum quality, or MG atrophy (all p ≥ 0.14).
Conclusion: At least some degree of MG tortuosity was commonly noted in both groups of subjects in the upper and lower eyelids. While tortuosity may not be a risk factor for CL dropout, tortuosity is potentially a sign of decreased MG health. Tortuosity may result in altered tear lipid production, which could result in the decreased meibum expressibility and reduced tear volume noted in this study.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: The etiology of MG tortuosity (deviated glands) is unknown, but it may be caused by chronic terminal duct obstruction or by genetic predisposition. The purpose of this study was to determine if MG tortuosity impacts successful contact lens (CL) wear and if the degree of tortuosity was associated with other signs or symptoms of ocular dryness.
Methods: This five-site case-control study recruited subjects between 18 and 45 years of age. Cases had ceased CL use within the past 6-12 months due to discomfort, while age- and sex-matched controls were able to comfortably wear CLs for ≥8 hours/day for ≥5 days/week. Each subject was administered a study-specific CL questionnaire and a SPEED questionnaire. Clinical testing included non-invasive tear break-up time (NITBUT), tear meniscus height (TMH), MG expressibility, meibum quality, and meibography (OCULUS Keratograph 5M). MG tortuosity for each eyelid was graded using the 5-point Halleran scale (Grade 0: no tortuosity; Grade 4: ≥75% of visible MG being tortuous). Worse eyes (determined by worse eye for tortuosity) comparisons were made with paired t-tests (means) or McNemar’s test (frequencies).
Result: 56 matched-pairs were recruited across sites. The mean ± SD age of the cases (28.5 ± 7.1 years) and controls (28.6 ± 7.0 years) were not significantly different (p = 0.66). MG tortuosity in control subjects with grade 2 or higher tortuosity was seen in 50% of the upper eyelid and 20% in the lower eyelid. The same intensity of MG tortuosity in dropout subjects was detected in 62% of the upper eyelid and 9% in the lower eyelid. The cases had significantly higher SPEED scores than the controls (6.42 ± 4.96 vs. 2.62 ± 2.66; p < 0.001). Cases did not have significantly higher upper (2.13 ± 1.09 vs. 1.80 ± 0.96; p = 0.07), lower (0.82 ± 0.64 vs. 1.00 ± 0.74; p = 0.12) or total (2.97 ± 1.30 vs. 2.80 ± 1.29; p = 0.39) eyelid tortuosity scores than controls. Tortuosity was significantly associated with TMH (p = 0.02), MG expressibility of upper (p = 0.03) and lower eyelids (p = 0.01) but not SPEED, NITBUT, meibum quality, or MG atrophy (all p ≥ 0.14).
Conclusion: At least some degree of MG tortuosity was commonly noted in both groups of subjects in the upper and lower eyelids. While tortuosity may not be a risk factor for CL dropout, tortuosity is potentially a sign of decreased MG health. Tortuosity may result in altered tear lipid production, which could result in the decreased meibum expressibility and reduced tear volume noted in this study.
Purpose: The etiology of MG tortuosity (deviated glands) is unknown, but it may be caused by chronic terminal duct obstruction or by genetic predisposition. The purpose of this study was to determine if MG tortuosity impacts successful contact lens (CL) wear and if the degree of tortuosity was associated with other signs or symptoms of ocular dryness.
Methods: This five-site case-control study recruited subjects between 18 and 45 years of age. Cases had ceased CL use within the past 6-12 months due to discomfort, while age- and sex-matched controls were able to comfortably wear CLs for ≥8 hours/day for ≥5 days/week. Each subject was administered a study-specific CL questionnaire and a SPEED questionnaire. Clinical testing included non-invasive tear break-up time (NITBUT), tear meniscus height (TMH), MG expressibility, meibum quality, and meibography (OCULUS Keratograph 5M). MG tortuosity for each eyelid was graded using the 5-point Halleran scale (Grade 0: no tortuosity; Grade 4: ≥75% of visible MG being tortuous). Worse eyes (determined by worse eye for tortuosity) comparisons were made with paired t-tests (means) or McNemar’s test (frequencies).
Result: 56 matched-pairs were recruited across sites. The mean ± SD age of the cases (28.5 ± 7.1 years) and controls (28.6 ± 7.0 years) were not significantly different (p = 0.66). MG tortuosity in control subjects with grade 2 or higher tortuosity was seen in 50% of the upper eyelid and 20% in the lower eyelid. The same intensity of MG tortuosity in dropout subjects was detected in 62% of the upper eyelid and 9% in the lower eyelid. The cases had significantly higher SPEED scores than the controls (6.42 ± 4.96 vs. 2.62 ± 2.66; p < 0.001). Cases did not have significantly higher upper (2.13 ± 1.09 vs. 1.80 ± 0.96; p = 0.07), lower (0.82 ± 0.64 vs. 1.00 ± 0.74; p = 0.12) or total (2.97 ± 1.30 vs. 2.80 ± 1.29; p = 0.39) eyelid tortuosity scores than controls. Tortuosity was significantly associated with TMH (p = 0.02), MG expressibility of upper (p = 0.03) and lower eyelids (p = 0.01) but not SPEED, NITBUT, meibum quality, or MG atrophy (all p ≥ 0.14).
Conclusion: At least some degree of MG tortuosity was commonly noted in both groups of subjects in the upper and lower eyelids. While tortuosity may not be a risk factor for CL dropout, tortuosity is potentially a sign of decreased MG health. Tortuosity may result in altered tear lipid production, which could result in the decreased meibum expressibility and reduced tear volume noted in this study.
Marx, Sebastian; Sickenberger, Wolfgang; Fahmy, Mary; Lemp-Hull, Jessie
Conference: Academy 2018 San Antonio - American Academy of Optometry 2018.
@conference{Marx2018b,
title = {Maintance of pre-lens tear film stability and daily comfort with EOBO-containing lens and lens care regimen throughout 30 days of lens wear},
author = {Sebastian Marx and Wolfgang Sickenberger and Mary Fahmy and Jessie Lemp-Hull
},
url = {https://www.jenvis-research.com/wp-content/uploads/2018/11/AAO-2018-Maintance-of-pre-lens-tear-film-stability-and-daily-comfort-with-EOBO-containing-lens-and-lens-care-regimen-throughout-30-days-of-lens-wear.pdf},
year = {2018},
date = {2018-11-09},
urldate = {2018-11-09},
organization = {Conference: Academy 2018 San Antonio - American Academy of Optometry},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Lievens, Christopher; Marx, Sebastian; Sickenberger, Wolfgang; Schwarz, Stefan; Shows, Amanda; Lemp, Jessi
Conference: Academy 2018 San Antonio - American Academy of Optometry 2018.
@conference{Lievens2018,
title = {Minimal Cholesterol Extraction and Maintance of Pre-Lens Tear Film Stability Associated with an EOBO-Containing Lens and Lens Care Regimen},
author = {Christopher Lievens and Sebastian Marx and Wolfgang Sickenberger and Stefan Schwarz and Amanda Shows and Jessi Lemp
},
url = {https://www.jenvis-research.com/wp-content/uploads/2018/11/AAO-2018-Minimal-Cholesterol-Extraction-and-Maintance-of-Pre-Lens-Tear-Film-Stability-Associated-with-an-EOBO-Containing-Lens-and-Lens-Care-Regimen.pdf},
year = {2018},
date = {2018-11-09},
urldate = {2018-11-09},
organization = {Conference: Academy 2018 San Antonio - American Academy of Optometry},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Pertzsch, Julia; Wittekind, Julia; Marx, Sebastian; Sickenberger, Wolfgang
Short Dry Eye Screening Questionnaire (JDEQS) in comparison with the established OSDI questionnaire Conference
Conference: Academy 2018 San Antonio - American Academy of Optometry 2018.
@conference{Pertzsch2018,
title = {Short Dry Eye Screening Questionnaire (JDEQS) in comparison with the established OSDI questionnaire},
author = {Julia Pertzsch and Julia Wittekind and Sebastian Marx and Wolfgang Sickenberger
},
url = {https://www.jenvis-research.com/wp-content/uploads/2018/11/AAO-2018-Short-Dry-Eye-Screening-Questionnaire-JDEQS-in-comparison-with-the-established-OSDI-questionnaire.pdf},
year = {2018},
date = {2018-11-09},
urldate = {2018-11-09},
organization = {Conference: Academy 2018 San Antonio - American Academy of Optometry},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Redfern, Rachel L.; Nichols, Jason J.; Sickenberger, Wolfgang; Fogt, Jennifer S.; Schulze, Marc; Lievens, Christopher; Szczotka-Flynn, Loretta; Schwarz, Stefan; Shows, Amanda; Lemp-Hull, Jessie
ARVO, 2018.
@conference{Redfern2018,
title = {Ex Vivo Analysis of Lipid Deposition with Silicone Hydrogel Contact Lenses and EOBO-Based Lens Care Solutions},
author = {Rachel L. Redfern and Jason J. Nichols and Wolfgang Sickenberger and Jennifer S. Fogt and Marc Schulze and Christopher Lievens and Loretta Szczotka-Flynn and Stefan Schwarz and Amanda Shows and
Jessie Lemp-Hull
},
url = {https://www.jenvis-research.com/wp-content/uploads/2018/06/ARVO-2018-ExVivoAnalysisofLipidDepositionwithSiHyCLandEOBOBasedLensCareSolutions-4.pdf},
year = {2018},
date = {2018-04-29},
urldate = {2018-04-29},
address = {ARVO},
abstract = {Abstract
Purpose : To compare the cholesterol deposition profile of a regimen of lotrafilcon B lenses packaged in blister solution containing the EOBO (polyoxyethylene-polyoxybutylene) wetting agent (AIR OPTIX plus HydraGlyde, AOHG) and lens care solutions formulated with EOBO (OPTI-FREE PureMoist, OFPM or CLEAR CARE PLUS, CCP) with a regimen of marketed silicone hydrogel (SiHy) lenses and marketed multipurpose solutions (MPS) that do not contain EOBO.
Methods : Adult, habitual SiHy lens wearers and habitual MPS users participated in a multi-center, prospective, stratified, controlled, parallel-group, masked study. Subjects (n=252) were randomized to wear either AOHG or habitual SiHy lenses (Acuvue Oasys, Acuvue Vita, Biofinity, or Ultra) daily for 30 (+3) days. Subjects in the AOHG lens group were further randomized to use either OFPM or CCP to care for their lenses. Lenses were replaced according to the manufacturer recommendation for each lens material. Subjects assigned to habitual SiHy lenses continued to use their habitual multipurpose solution (HMPS). Lenses (n=20 to 28 per regimen) were collected for assessment of total cholesterol uptake. Cholesterol sorption was measured using a fluorometric enzymatic assay as previously described (Nash et al, E&CL 2014).
Results : AOHG/CCP regimen demonstrated significantly less cholesterol uptake (median = 0.30 µg) than the following regimens: Biofinity/HMPS (median = 1.55 µg), Vita/HMPS (median = 4.20 µg), Ultra/HMPS (median = 1.90 mg) and Oasys/HMPS (median = 1.55 mg), (p < 0.0001 for all). Likewise, the AOHG/OFPM regimen had significantly less cholesterol uptake (median = 0.10 µg) than all habitual lens and solution regimens (p < 0.0001 for all).
Conclusions : The AOHG/CCP and AOHG/OFPM regimens resulted in less cholesterol sorption than each of the habitual SiHy/MPS regimens (p < 0.0001). Further research is necessary to understand the impact of cholesterol deposition on patient clinical outcomes.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose : To compare the cholesterol deposition profile of a regimen of lotrafilcon B lenses packaged in blister solution containing the EOBO (polyoxyethylene-polyoxybutylene) wetting agent (AIR OPTIX plus HydraGlyde, AOHG) and lens care solutions formulated with EOBO (OPTI-FREE PureMoist, OFPM or CLEAR CARE PLUS, CCP) with a regimen of marketed silicone hydrogel (SiHy) lenses and marketed multipurpose solutions (MPS) that do not contain EOBO.
Methods : Adult, habitual SiHy lens wearers and habitual MPS users participated in a multi-center, prospective, stratified, controlled, parallel-group, masked study. Subjects (n=252) were randomized to wear either AOHG or habitual SiHy lenses (Acuvue Oasys, Acuvue Vita, Biofinity, or Ultra) daily for 30 (+3) days. Subjects in the AOHG lens group were further randomized to use either OFPM or CCP to care for their lenses. Lenses were replaced according to the manufacturer recommendation for each lens material. Subjects assigned to habitual SiHy lenses continued to use their habitual multipurpose solution (HMPS). Lenses (n=20 to 28 per regimen) were collected for assessment of total cholesterol uptake. Cholesterol sorption was measured using a fluorometric enzymatic assay as previously described (Nash et al, E&CL 2014).
Results : AOHG/CCP regimen demonstrated significantly less cholesterol uptake (median = 0.30 µg) than the following regimens: Biofinity/HMPS (median = 1.55 µg), Vita/HMPS (median = 4.20 µg), Ultra/HMPS (median = 1.90 mg) and Oasys/HMPS (median = 1.55 mg), (p < 0.0001 for all). Likewise, the AOHG/OFPM regimen had significantly less cholesterol uptake (median = 0.10 µg) than all habitual lens and solution regimens (p < 0.0001 for all).
Conclusions : The AOHG/CCP and AOHG/OFPM regimens resulted in less cholesterol sorption than each of the habitual SiHy/MPS regimens (p < 0.0001). Further research is necessary to understand the impact of cholesterol deposition on patient clinical outcomes.
Purpose : To compare the cholesterol deposition profile of a regimen of lotrafilcon B lenses packaged in blister solution containing the EOBO (polyoxyethylene-polyoxybutylene) wetting agent (AIR OPTIX plus HydraGlyde, AOHG) and lens care solutions formulated with EOBO (OPTI-FREE PureMoist, OFPM or CLEAR CARE PLUS, CCP) with a regimen of marketed silicone hydrogel (SiHy) lenses and marketed multipurpose solutions (MPS) that do not contain EOBO.
Methods : Adult, habitual SiHy lens wearers and habitual MPS users participated in a multi-center, prospective, stratified, controlled, parallel-group, masked study. Subjects (n=252) were randomized to wear either AOHG or habitual SiHy lenses (Acuvue Oasys, Acuvue Vita, Biofinity, or Ultra) daily for 30 (+3) days. Subjects in the AOHG lens group were further randomized to use either OFPM or CCP to care for their lenses. Lenses were replaced according to the manufacturer recommendation for each lens material. Subjects assigned to habitual SiHy lenses continued to use their habitual multipurpose solution (HMPS). Lenses (n=20 to 28 per regimen) were collected for assessment of total cholesterol uptake. Cholesterol sorption was measured using a fluorometric enzymatic assay as previously described (Nash et al, E&CL 2014).
Results : AOHG/CCP regimen demonstrated significantly less cholesterol uptake (median = 0.30 µg) than the following regimens: Biofinity/HMPS (median = 1.55 µg), Vita/HMPS (median = 4.20 µg), Ultra/HMPS (median = 1.90 mg) and Oasys/HMPS (median = 1.55 mg), (p < 0.0001 for all). Likewise, the AOHG/OFPM regimen had significantly less cholesterol uptake (median = 0.10 µg) than all habitual lens and solution regimens (p < 0.0001 for all).
Conclusions : The AOHG/CCP and AOHG/OFPM regimens resulted in less cholesterol sorption than each of the habitual SiHy/MPS regimens (p < 0.0001). Further research is necessary to understand the impact of cholesterol deposition on patient clinical outcomes.
2017
Marx, Sebastian; Sickenberger, Wolfgang
A novel in-vitro method for assessing contact lens surface dewetting: Non-invasive keratograph dry-up time (NIK-DUT) Journal Article
In: Contact Lens and Anterior Eye, vol. 40, 2017.
@article{Marx2017,
title = {A novel in-vitro method for assessing contact lens surface dewetting: Non-invasive keratograph dry-up time (NIK-DUT)},
author = {Sebastian Marx and Wolfgang Sickenberger },
url = {http://dx.doi.org/10.1016/j.clae.2017.05.001},
year = {2017},
date = {2017-08-25},
urldate = {2017-08-25},
journal = {Contact Lens and Anterior Eye},
volume = {40},
abstract = {Abstract
Purpose: This study was designed to develop a novel technique called non-invasive keratograph dry-up time (NIK-DUT), which used an adapted corneal topographer, to analyse in-vitro contact lens surface dewetting and the effects of combinations of lenses and lens care solutions on dewetting.
Methods: Variables were assessed to optimise sensitivity and reproducibility. To validate the method, in-vitro dewetting of silicone hydrogel contact lenses (balafilcon A, comfilcon A, lotrafilcon A, lotrafilcon B and senofilcon A) was tested. All lens types were soaked in OPTI-FREE® PureMoist® Multipurpose Disinfecting Solution (OFPM) and Sensitive Eyes® Saline Solution. The mean NIK-DUT, defined as drying of 25% of the placido ring measurement segments (NIK-DUT_S25), was calculated for each lens/lens solution combination and a visual map constructed representing the time and location of the dry-up event.
Results: Optimal conditions for NIK-DUT measurement included mounting onto a glass stage with a surface geometry of r = 8.5 mm, e = 0, and measuring with high intensity red or white illumination. This method detected significant differences in contact lens dewetting with different lens soaking solutions. NIK-DUT_S25 for all lenses was longer when pre-soaked in OFPM versus saline. Visual analysis showed that dewetting of contact lenses was not uniform across surfaces and differed between test solutions.
Conclusions: NIK-DUT is suitable for detecting differences in dewetting among various contact lenses and lens-care combinations. NIK-DUT can quantify the dewetting of large areas of lens surfaces with little subjective influence. Lens care solutions containing surface-active wetting agents were found to delay surface dewetting of silicone hydrogel lenses.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Purpose: This study was designed to develop a novel technique called non-invasive keratograph dry-up time (NIK-DUT), which used an adapted corneal topographer, to analyse in-vitro contact lens surface dewetting and the effects of combinations of lenses and lens care solutions on dewetting.
Methods: Variables were assessed to optimise sensitivity and reproducibility. To validate the method, in-vitro dewetting of silicone hydrogel contact lenses (balafilcon A, comfilcon A, lotrafilcon A, lotrafilcon B and senofilcon A) was tested. All lens types were soaked in OPTI-FREE® PureMoist® Multipurpose Disinfecting Solution (OFPM) and Sensitive Eyes® Saline Solution. The mean NIK-DUT, defined as drying of 25% of the placido ring measurement segments (NIK-DUT_S25), was calculated for each lens/lens solution combination and a visual map constructed representing the time and location of the dry-up event.
Results: Optimal conditions for NIK-DUT measurement included mounting onto a glass stage with a surface geometry of r = 8.5 mm, e = 0, and measuring with high intensity red or white illumination. This method detected significant differences in contact lens dewetting with different lens soaking solutions. NIK-DUT_S25 for all lenses was longer when pre-soaked in OFPM versus saline. Visual analysis showed that dewetting of contact lenses was not uniform across surfaces and differed between test solutions.
Conclusions: NIK-DUT is suitable for detecting differences in dewetting among various contact lenses and lens-care combinations. NIK-DUT can quantify the dewetting of large areas of lens surfaces with little subjective influence. Lens care solutions containing surface-active wetting agents were found to delay surface dewetting of silicone hydrogel lenses.
Purpose: This study was designed to develop a novel technique called non-invasive keratograph dry-up time (NIK-DUT), which used an adapted corneal topographer, to analyse in-vitro contact lens surface dewetting and the effects of combinations of lenses and lens care solutions on dewetting.
Methods: Variables were assessed to optimise sensitivity and reproducibility. To validate the method, in-vitro dewetting of silicone hydrogel contact lenses (balafilcon A, comfilcon A, lotrafilcon A, lotrafilcon B and senofilcon A) was tested. All lens types were soaked in OPTI-FREE® PureMoist® Multipurpose Disinfecting Solution (OFPM) and Sensitive Eyes® Saline Solution. The mean NIK-DUT, defined as drying of 25% of the placido ring measurement segments (NIK-DUT_S25), was calculated for each lens/lens solution combination and a visual map constructed representing the time and location of the dry-up event.
Results: Optimal conditions for NIK-DUT measurement included mounting onto a glass stage with a surface geometry of r = 8.5 mm, e = 0, and measuring with high intensity red or white illumination. This method detected significant differences in contact lens dewetting with different lens soaking solutions. NIK-DUT_S25 for all lenses was longer when pre-soaked in OFPM versus saline. Visual analysis showed that dewetting of contact lenses was not uniform across surfaces and differed between test solutions.
Conclusions: NIK-DUT is suitable for detecting differences in dewetting among various contact lenses and lens-care combinations. NIK-DUT can quantify the dewetting of large areas of lens surfaces with little subjective influence. Lens care solutions containing surface-active wetting agents were found to delay surface dewetting of silicone hydrogel lenses.
Sickenberger, Wolfgang
Eins, Zwei, Drei – A German's perspective on dry eye numbers in the world Journal Article
In: Contact Lens and Anterior Eye, vol. 40, pp. 1-2, 2017.
@article{Sickenberger2017,
title = {Eins, Zwei, Drei – A German's perspective on dry eye numbers in the world},
author = {Wolfgang Sickenberger},
doi = {https://doi.org/10.1016/j.clae.2016.12.005},
year = {2017},
date = {2017-02-01},
urldate = {2017-02-01},
journal = {Contact Lens and Anterior Eye},
volume = {40},
pages = {1-2},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
2016
Marx, Sebastian; Sickenberger, Wolfgang
no. 165113, American Academy of Optometry Anaheim, 2016.
@conference{Marx2016,
title = {Wettability of different silicone hydrogel lens materials and blister solutions measured using non-invasive keratographic drying up time (NIK-DUT)},
author = {Sebastian Marx and Wolfgang Sickenberger },
url = {https://www.jenvis-research.com/wp-content/uploads/2017/02/AAO-2016-Poster-Marx-Wettability-of-different-silicone-hydrogel-lens-materials.pdf},
year = {2016},
date = {2016-11-09},
urldate = {2016-11-09},
number = {165113},
address = { Anaheim},
organization = {American Academy of Optometry},
abstract = {Abstract
Objective: The primary objective of the study was to determine differences between the surface wettability of silicon hydrogel (SiHy) lens materials and blister pack solutions measured in vitro using a modified corneal topographer (Non-Invasive Keratograph – Drying-Up Time [NIK-DUT]).
Method and Materials: 20 lenses each of the following commercially available SiHy materials and blister solutions were tested: senofilcon A, comfilcon A, samfilcon A, lotrafilcon B/copolymer 845, lotrafilcon B copolymer 845+EOBO-41. The NIK-DUT video was captured with a modified Oculus Keratograph 5M. The NIK-DUT was determined by evaluation of the reflected placido-ring image during a measurement time of 180 sec by a trained investigator. The focus was on the measurement of the area under the curve (AUC, cumulative dry-up over 180 seconds) and the determination of the time point derived when 25% of the entire measurement segments showed dry-up during the measuring time (NIK-DUT_S25). Based on asymptotic, not normally distributed data, the Kruskal Wallis test was conducted to determine effect of lens material/blister solution (alpha 0.05).
Results: The AUC results were as follows: 9463% comfilcon A, 7964% samfilcon A, 7033% senofilcon A, 5592% lotrafilcon B/copolymer 845 and 4680% for lotrafilcon B/ copolymer 845+EOBO-41 and were statistically significantly different, p = 0.001. NIK-DUT_S25 comparison showed the following order: 72sec comfilcon A, 79sec samfilcon A, 93sec lotrafilcon B/copolymer 845, 96sec senofilcon A and 123sec for lotrafilcon B copolymer 845+EOBO-41.
Conclusion: There are significant differences between the wettability performances of different lens materials measured directly out of the packaging solution. Within lotrafilcon B lenses, the EOBO-41 maintained the wettability of the lens surface longer. Blister solutions containing specifically designed agents to improve lens surface wettability may bring benefits like improved comfort and vision to the contact lens wearer.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Objective: The primary objective of the study was to determine differences between the surface wettability of silicon hydrogel (SiHy) lens materials and blister pack solutions measured in vitro using a modified corneal topographer (Non-Invasive Keratograph – Drying-Up Time [NIK-DUT]).
Method and Materials: 20 lenses each of the following commercially available SiHy materials and blister solutions were tested: senofilcon A, comfilcon A, samfilcon A, lotrafilcon B/copolymer 845, lotrafilcon B copolymer 845+EOBO-41. The NIK-DUT video was captured with a modified Oculus Keratograph 5M. The NIK-DUT was determined by evaluation of the reflected placido-ring image during a measurement time of 180 sec by a trained investigator. The focus was on the measurement of the area under the curve (AUC, cumulative dry-up over 180 seconds) and the determination of the time point derived when 25% of the entire measurement segments showed dry-up during the measuring time (NIK-DUT_S25). Based on asymptotic, not normally distributed data, the Kruskal Wallis test was conducted to determine effect of lens material/blister solution (alpha 0.05).
Results: The AUC results were as follows: 9463% comfilcon A, 7964% samfilcon A, 7033% senofilcon A, 5592% lotrafilcon B/copolymer 845 and 4680% for lotrafilcon B/ copolymer 845+EOBO-41 and were statistically significantly different, p = 0.001. NIK-DUT_S25 comparison showed the following order: 72sec comfilcon A, 79sec samfilcon A, 93sec lotrafilcon B/copolymer 845, 96sec senofilcon A and 123sec for lotrafilcon B copolymer 845+EOBO-41.
Conclusion: There are significant differences between the wettability performances of different lens materials measured directly out of the packaging solution. Within lotrafilcon B lenses, the EOBO-41 maintained the wettability of the lens surface longer. Blister solutions containing specifically designed agents to improve lens surface wettability may bring benefits like improved comfort and vision to the contact lens wearer.
Objective: The primary objective of the study was to determine differences between the surface wettability of silicon hydrogel (SiHy) lens materials and blister pack solutions measured in vitro using a modified corneal topographer (Non-Invasive Keratograph – Drying-Up Time [NIK-DUT]).
Method and Materials: 20 lenses each of the following commercially available SiHy materials and blister solutions were tested: senofilcon A, comfilcon A, samfilcon A, lotrafilcon B/copolymer 845, lotrafilcon B copolymer 845+EOBO-41. The NIK-DUT video was captured with a modified Oculus Keratograph 5M. The NIK-DUT was determined by evaluation of the reflected placido-ring image during a measurement time of 180 sec by a trained investigator. The focus was on the measurement of the area under the curve (AUC, cumulative dry-up over 180 seconds) and the determination of the time point derived when 25% of the entire measurement segments showed dry-up during the measuring time (NIK-DUT_S25). Based on asymptotic, not normally distributed data, the Kruskal Wallis test was conducted to determine effect of lens material/blister solution (alpha 0.05).
Results: The AUC results were as follows: 9463% comfilcon A, 7964% samfilcon A, 7033% senofilcon A, 5592% lotrafilcon B/copolymer 845 and 4680% for lotrafilcon B/ copolymer 845+EOBO-41 and were statistically significantly different, p = 0.001. NIK-DUT_S25 comparison showed the following order: 72sec comfilcon A, 79sec samfilcon A, 93sec lotrafilcon B/copolymer 845, 96sec senofilcon A and 123sec for lotrafilcon B copolymer 845+EOBO-41.
Conclusion: There are significant differences between the wettability performances of different lens materials measured directly out of the packaging solution. Within lotrafilcon B lenses, the EOBO-41 maintained the wettability of the lens surface longer. Blister solutions containing specifically designed agents to improve lens surface wettability may bring benefits like improved comfort and vision to the contact lens wearer.
Marx, Sebastian; Maissa, Cecile; Wittekind, Julia; Sickenberger, Wolfgang
Global Specialty Lens Symposium Las Vegas, 2016.
@conference{Marx2016b,
title = {Comparison of Pre Lens Tear Film Stability of Nelfilcon A with Different Optical Designs Using Placido Ring Projection},
author = {Sebastian Marx and Cecile Maissa and Julia Wittekind and Wolfgang Sickenberger},
url = {https://www.jenvis-research.com/wp-content/uploads/2017/02/GLSL2016_Marx_Dailies_Pre_lens_tear_film_POS.pdf},
year = {2016},
date = {2016-01-21},
urldate = {2016-01-21},
address = {Las Vegas},
organization = {Global Specialty Lens Symposium},
abstract = {Abstract
Purposes: The aim of the study was to evaluate the pre lens tear film characteristics of nelfilcon A daily disposable contact lenses with either toric or multifocal design compared to nelfilcon A daily disposable lenses with a spherical design over 12 hours of lens wear. A further objective of the study was to evaluate the day-to-day and inter-subject variability of tear film characteristics assessed using the Oculus K5 imaging system.
Method: 48 adult soft contact lens wearers, aged 18 years and over, including 24 presbyopes, were enrolled. Three single test days/periods with a wash out phase of at least 48hours were planned for each subject. The subjects wore either the spherical nelfilcon A design or the specialized toric or multifocal design at test period one according to their group and on test period two vice versa in a randomized order. At test period three all subjects wear the spherical nelfilcon A design. Tear film videos using the K5 Oculus-Imaging Live Mode with projected ring mires onto the lens surface were taken after three different time points post contact lens insertion (5min, 8hrs and 12hrs) to determine pre-lens tear film stability.
Results: The results showed that, for either population, the specialized designs did not adversely affect the on eye wettability: i. in presbyopes, the overall relative risk (RR) of a Grade 2 or 3 surface wettability between nelfilcon A multifocal and nelfilcon A sphere after 12 hours of wear was 1.06, and the lower limit (0.96) of 95% CI of overall RR was ≤1. In astigmats, the overall relative risk (RR) of a Grade 2 or 3 surface wettability between the toric and spherical design after 12 hours of wear was 0.90, and the lower limit (0.79) of 95% CI of overall RR was ≤1.
Conclusion: The study established the inter- as well as intra-subject variation of the tear film characteristics measurements over 25 sec post blink using this method. The surface wettability of nelfilcon A multifocal and toric daily disposable contact lenses was shown to be at least as good as that of the spherical design after 12 hrs of lens wear, demonstrating that the wettability was not affected by the optical design of the lens.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purposes: The aim of the study was to evaluate the pre lens tear film characteristics of nelfilcon A daily disposable contact lenses with either toric or multifocal design compared to nelfilcon A daily disposable lenses with a spherical design over 12 hours of lens wear. A further objective of the study was to evaluate the day-to-day and inter-subject variability of tear film characteristics assessed using the Oculus K5 imaging system.
Method: 48 adult soft contact lens wearers, aged 18 years and over, including 24 presbyopes, were enrolled. Three single test days/periods with a wash out phase of at least 48hours were planned for each subject. The subjects wore either the spherical nelfilcon A design or the specialized toric or multifocal design at test period one according to their group and on test period two vice versa in a randomized order. At test period three all subjects wear the spherical nelfilcon A design. Tear film videos using the K5 Oculus-Imaging Live Mode with projected ring mires onto the lens surface were taken after three different time points post contact lens insertion (5min, 8hrs and 12hrs) to determine pre-lens tear film stability.
Results: The results showed that, for either population, the specialized designs did not adversely affect the on eye wettability: i. in presbyopes, the overall relative risk (RR) of a Grade 2 or 3 surface wettability between nelfilcon A multifocal and nelfilcon A sphere after 12 hours of wear was 1.06, and the lower limit (0.96) of 95% CI of overall RR was ≤1. In astigmats, the overall relative risk (RR) of a Grade 2 or 3 surface wettability between the toric and spherical design after 12 hours of wear was 0.90, and the lower limit (0.79) of 95% CI of overall RR was ≤1.
Conclusion: The study established the inter- as well as intra-subject variation of the tear film characteristics measurements over 25 sec post blink using this method. The surface wettability of nelfilcon A multifocal and toric daily disposable contact lenses was shown to be at least as good as that of the spherical design after 12 hrs of lens wear, demonstrating that the wettability was not affected by the optical design of the lens.
Purposes: The aim of the study was to evaluate the pre lens tear film characteristics of nelfilcon A daily disposable contact lenses with either toric or multifocal design compared to nelfilcon A daily disposable lenses with a spherical design over 12 hours of lens wear. A further objective of the study was to evaluate the day-to-day and inter-subject variability of tear film characteristics assessed using the Oculus K5 imaging system.
Method: 48 adult soft contact lens wearers, aged 18 years and over, including 24 presbyopes, were enrolled. Three single test days/periods with a wash out phase of at least 48hours were planned for each subject. The subjects wore either the spherical nelfilcon A design or the specialized toric or multifocal design at test period one according to their group and on test period two vice versa in a randomized order. At test period three all subjects wear the spherical nelfilcon A design. Tear film videos using the K5 Oculus-Imaging Live Mode with projected ring mires onto the lens surface were taken after three different time points post contact lens insertion (5min, 8hrs and 12hrs) to determine pre-lens tear film stability.
Results: The results showed that, for either population, the specialized designs did not adversely affect the on eye wettability: i. in presbyopes, the overall relative risk (RR) of a Grade 2 or 3 surface wettability between nelfilcon A multifocal and nelfilcon A sphere after 12 hours of wear was 1.06, and the lower limit (0.96) of 95% CI of overall RR was ≤1. In astigmats, the overall relative risk (RR) of a Grade 2 or 3 surface wettability between the toric and spherical design after 12 hours of wear was 0.90, and the lower limit (0.79) of 95% CI of overall RR was ≤1.
Conclusion: The study established the inter- as well as intra-subject variation of the tear film characteristics measurements over 25 sec post blink using this method. The surface wettability of nelfilcon A multifocal and toric daily disposable contact lenses was shown to be at least as good as that of the spherical design after 12 hrs of lens wear, demonstrating that the wettability was not affected by the optical design of the lens.
2015
Maissa, Cecile; Marx, Sebastian; Wittekind, Julia; Sickenberger, Wolfgang
no. 155699, American Academy of Optometry, 2015.
@conference{Maissa2015,
title = {Variability of Pre Ocular and Pre Lens Tear Film Stability Assessed Subjectively and Objectively Using Placido Ring Projection},
author = {Cecile Maissa and Sebastian Marx and Julia Wittekind and Wolfgang Sickenberger},
url = {http://www.aaopt.org/variability-pre-ocular-and-pre-lens-tear-film-stability-assessed-subjectively-and-objectively-using
https://www.jenvis-research.com/wp-content/uploads/2017/09/1281-AAOpt-Maissa-10-05-15_CM.pdf},
year = {2015},
date = {2015-10-09},
urldate = {2015-10-09},
number = {155699},
address = {American Academy of Optometry},
abstract = {Abstract
Purpose: The objective of the study was to characterize the tear film (TF) stability over 12 hours of nelfilcon A daily disposable contact lens wear and evaluate its day-to-day and inter-subject variability.
Methods: 48 adapted soft contact lens wearers aged 18 years and over, including 24 presbyopes, were enrolled. Each subject attended two 12-h wear periods of nelfilcon A daily disposable contact lenses. During each period of wear, TF videos using the K5 Oculus-Imaging Live Mode and Ring Mire System projected onto the ocular surface were recorded before contact lens insertion (POTF) and at three different time points post contact lens insertion (PLTF) (5 m, 8 h, and 12 h post insertion). The TF characteristics were measured subjectively in terms of surface wettability grading and break up time and semi-objectively in terms of area under the curve (AUC) of % distortion with time, maximum % distortion over 25 s post blink, and % distortion at 5 s and 10 sec post blink.
Results: The results showed differences in tear film characteristics between the POTF and PLTF situations; the time to first distortion decreased by 18% to ~50% in the presence of a contact lens. The maximum % distortion recorded over 25 s post blink increased from an average of 10-15% for the POTF to 26-36% at 5 m, 8 h, and 12 h post lens insertion. Within each testing condition (POTF & PLTF) the inter-subject variability, expressed as the coefficient of variation, ranged from 48-69% for the time to first distortion and 65-170% for the maximum % distortion. The day-to-day variability was also calculated (Time to first distortion Mean Diff: -1.20 to 1.15 s).
Conclusion: The study established the inter- as well as intra-subject variation of subjective and semi-objective measurements of the TF characteristics over 25 s post blink using this method. The new objective endpoints used provided valuable insight as to TF kinetics during the interblink period in the presence or absence of a contact lens.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: The objective of the study was to characterize the tear film (TF) stability over 12 hours of nelfilcon A daily disposable contact lens wear and evaluate its day-to-day and inter-subject variability.
Methods: 48 adapted soft contact lens wearers aged 18 years and over, including 24 presbyopes, were enrolled. Each subject attended two 12-h wear periods of nelfilcon A daily disposable contact lenses. During each period of wear, TF videos using the K5 Oculus-Imaging Live Mode and Ring Mire System projected onto the ocular surface were recorded before contact lens insertion (POTF) and at three different time points post contact lens insertion (PLTF) (5 m, 8 h, and 12 h post insertion). The TF characteristics were measured subjectively in terms of surface wettability grading and break up time and semi-objectively in terms of area under the curve (AUC) of % distortion with time, maximum % distortion over 25 s post blink, and % distortion at 5 s and 10 sec post blink.
Results: The results showed differences in tear film characteristics between the POTF and PLTF situations; the time to first distortion decreased by 18% to ~50% in the presence of a contact lens. The maximum % distortion recorded over 25 s post blink increased from an average of 10-15% for the POTF to 26-36% at 5 m, 8 h, and 12 h post lens insertion. Within each testing condition (POTF & PLTF) the inter-subject variability, expressed as the coefficient of variation, ranged from 48-69% for the time to first distortion and 65-170% for the maximum % distortion. The day-to-day variability was also calculated (Time to first distortion Mean Diff: -1.20 to 1.15 s).
Conclusion: The study established the inter- as well as intra-subject variation of subjective and semi-objective measurements of the TF characteristics over 25 s post blink using this method. The new objective endpoints used provided valuable insight as to TF kinetics during the interblink period in the presence or absence of a contact lens.
Purpose: The objective of the study was to characterize the tear film (TF) stability over 12 hours of nelfilcon A daily disposable contact lens wear and evaluate its day-to-day and inter-subject variability.
Methods: 48 adapted soft contact lens wearers aged 18 years and over, including 24 presbyopes, were enrolled. Each subject attended two 12-h wear periods of nelfilcon A daily disposable contact lenses. During each period of wear, TF videos using the K5 Oculus-Imaging Live Mode and Ring Mire System projected onto the ocular surface were recorded before contact lens insertion (POTF) and at three different time points post contact lens insertion (PLTF) (5 m, 8 h, and 12 h post insertion). The TF characteristics were measured subjectively in terms of surface wettability grading and break up time and semi-objectively in terms of area under the curve (AUC) of % distortion with time, maximum % distortion over 25 s post blink, and % distortion at 5 s and 10 sec post blink.
Results: The results showed differences in tear film characteristics between the POTF and PLTF situations; the time to first distortion decreased by 18% to ~50% in the presence of a contact lens. The maximum % distortion recorded over 25 s post blink increased from an average of 10-15% for the POTF to 26-36% at 5 m, 8 h, and 12 h post lens insertion. Within each testing condition (POTF & PLTF) the inter-subject variability, expressed as the coefficient of variation, ranged from 48-69% for the time to first distortion and 65-170% for the maximum % distortion. The day-to-day variability was also calculated (Time to first distortion Mean Diff: -1.20 to 1.15 s).
Conclusion: The study established the inter- as well as intra-subject variation of subjective and semi-objective measurements of the TF characteristics over 25 s post blink using this method. The new objective endpoints used provided valuable insight as to TF kinetics during the interblink period in the presence or absence of a contact lens.
Pucker, Andrew D.; Jones-Jordan, Lisa A.; Li, Wing; Kwan, Justin T.; Lin, Meng C.; Sickenberger, Wolfgang; Marx, Sebastian; Srinivasan, Sruthi; Jones, Lyndon W.
Associations with Meibomian Gland Atrophy in Daily Contact Lens Wearers Journal Article
In: Optometry and vision science : official publication of the American Academy of Optometry, vol. 92, no. 9, pp. e206-13, 2015, ISSN: 1040-5488.
@article{Pucker.2015,
title = {Associations with Meibomian Gland Atrophy in Daily Contact Lens Wearers},
author = {Andrew D. Pucker and Lisa A. Jones-Jordan and Wing Li and Justin T. Kwan and Meng C. Lin and Wolfgang Sickenberger and Sebastian Marx and Sruthi Srinivasan and Lyndon W. Jones
},
url = {http://journals.lww.com/optvissci/pages/articleviewer.aspx?year=2015&issue=09000&article=00012&type=abstract
https://www.jenvis-research.com/wp-content/uploads/2014/11/Bo_Lauenborg.jpg},
doi = {10.1097/OPX.0000000000000650},
issn = {1040-5488},
year = {2015},
date = {2015-09-01},
urldate = {2015-09-01},
journal = {Optometry and vision science : official publication of the American Academy of Optometry},
volume = {92},
number = {9},
pages = {e206-13},
abstract = {Abstract
Purpose: To determine associations for contact lenses (CLs) and meibomian gland atrophy in a matched-pair study.
Methods: Contact lens wearers (case) and age- and sex-matched non-contact lens (NCL) wearers with no history of CL use (control) were recruited for a multicenter study. All subjects were administered the Ocular Surface Disease Index questionnaire and a comprehensive battery of clinical tests (e.g., tear breakup time, bulbar and limbal redness, meibography, etc.) were performed. Upper and lower eyelid meibomian gland atrophy were graded with both digital meibography (percent gland atrophy) and visual meiboscore methods. Conditional logistic regression analyses were then used to determine relationships among CL use, meibomian gland atrophy, and ocular surface signs and symptoms.
Results: A total of 70 matched pairs were analyzed. The mean (+/- SD) age of the CL group was 30.6 (+/- 12.4) years, and that of the NCL group was 30.1 (+/- 12.2) years. The subjects were 63% female. The association between CL wear and meiboscore was not significant univariately, but the best-fitting multivariate regression model showed that higher meiboscores were associated with being a CL wearer (odds ratio [OR], 2.45) in a model that included eyelid margin erythema (OR, 0.25) and lissamine green staining (OR, 1.25). Percent gland atrophy was not associated with CL wear in regression analysis (p = 0.31).
Conclusion: This study determined inconclusive associations with CLs and meibomian gland atrophy. This study also provided a comprehensive assessment of differences between CL and NCL wearers.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Purpose: To determine associations for contact lenses (CLs) and meibomian gland atrophy in a matched-pair study.
Methods: Contact lens wearers (case) and age- and sex-matched non-contact lens (NCL) wearers with no history of CL use (control) were recruited for a multicenter study. All subjects were administered the Ocular Surface Disease Index questionnaire and a comprehensive battery of clinical tests (e.g., tear breakup time, bulbar and limbal redness, meibography, etc.) were performed. Upper and lower eyelid meibomian gland atrophy were graded with both digital meibography (percent gland atrophy) and visual meiboscore methods. Conditional logistic regression analyses were then used to determine relationships among CL use, meibomian gland atrophy, and ocular surface signs and symptoms.
Results: A total of 70 matched pairs were analyzed. The mean (+/- SD) age of the CL group was 30.6 (+/- 12.4) years, and that of the NCL group was 30.1 (+/- 12.2) years. The subjects were 63% female. The association between CL wear and meiboscore was not significant univariately, but the best-fitting multivariate regression model showed that higher meiboscores were associated with being a CL wearer (odds ratio [OR], 2.45) in a model that included eyelid margin erythema (OR, 0.25) and lissamine green staining (OR, 1.25). Percent gland atrophy was not associated with CL wear in regression analysis (p = 0.31).
Conclusion: This study determined inconclusive associations with CLs and meibomian gland atrophy. This study also provided a comprehensive assessment of differences between CL and NCL wearers.
Purpose: To determine associations for contact lenses (CLs) and meibomian gland atrophy in a matched-pair study.
Methods: Contact lens wearers (case) and age- and sex-matched non-contact lens (NCL) wearers with no history of CL use (control) were recruited for a multicenter study. All subjects were administered the Ocular Surface Disease Index questionnaire and a comprehensive battery of clinical tests (e.g., tear breakup time, bulbar and limbal redness, meibography, etc.) were performed. Upper and lower eyelid meibomian gland atrophy were graded with both digital meibography (percent gland atrophy) and visual meiboscore methods. Conditional logistic regression analyses were then used to determine relationships among CL use, meibomian gland atrophy, and ocular surface signs and symptoms.
Results: A total of 70 matched pairs were analyzed. The mean (+/- SD) age of the CL group was 30.6 (+/- 12.4) years, and that of the NCL group was 30.1 (+/- 12.2) years. The subjects were 63% female. The association between CL wear and meiboscore was not significant univariately, but the best-fitting multivariate regression model showed that higher meiboscores were associated with being a CL wearer (odds ratio [OR], 2.45) in a model that included eyelid margin erythema (OR, 0.25) and lissamine green staining (OR, 1.25). Percent gland atrophy was not associated with CL wear in regression analysis (p = 0.31).
Conclusion: This study determined inconclusive associations with CLs and meibomian gland atrophy. This study also provided a comprehensive assessment of differences between CL and NCL wearers.
Müller, Christiane; Marx, Sebastian; Sickenberger, Wolfgang
Programme and Abstracts - Budapest 2015, no. 28, European Academy of Optometry and Optics 2015.
@conference{Müller2015,
title = {Subjective Comparison of Pre-Lens Tear Film Stability of Daily Disposable Contact Lenses Using Modern Video Topography},
author = {Christiane Müller and Sebastian Marx and Wolfgang Sickenberger},
url = {https://www.jenvis-research.com/wp-content/uploads/2017/09/Poster_EAOO_JenVis_final.pdf},
year = {2015},
date = {2015-05-14},
urldate = {2015-05-14},
booktitle = {Programme and Abstracts - Budapest 2015},
number = {28},
pages = {139},
organization = {European Academy of Optometry and Optics},
abstract = {Abstract
Purpose: To evaluate the in vivo tear film stability of three different daily disposable contact lenses (DDCLs) using the ring mire projection of the Keratograph 5M (Oculus) after five minutes, eight hours, and 12 hours of wear.
Methods: Three DDCLs (nelfilcon A, etafilcon A, omafilcon A) were tested on 28 subjects in a prospective, randomised, observer masked cross-over study. From the video recordings, the pre-lens non-invasive keratopgraph-drying-up time (PL NIK-DUT) was determined subjective and the surface wettability graded (0=no visible distortions to 3=distortions in >1/3 of the ring reflection zone) at five, ten, 15, 20 and 25 seconds post-blink after five minutes, eight hours and 12 hours of wear. Medians of PL NIK-DUTs and wettability values of three observers were analysed statistically.
Results: Whereas the PL NIK-DUT was not statistically significantly different between lenses (five min nelfilcon A:4.75±5.36 sec, etafilcon A:5.38±4.50 sec, omafilcon A:6.68±5.00 sec p=0.626; 8 hrs nelfilcon A:5.28±5.71 sec, etafilcon A:3.46±4.52 sec, omafilcon A:4.93±6.34 sec p=0.292; 12 hrs nelfilcon A:5.50±5.43 sec, etafilcon A:4.66± 6.0 sec, omafilcon A:5.85±5.73 sec p=0.614), the subjective wettability grades showed significant differences after 12 hrs with 1.24±1.17 sec for nelfilcon A, 1.43±1.20 sec for etafilcon A and 1.21±1.19 sec for omafilcon A (p=0.001; Kruskal-Wallis-Test).
Conclusion: The study showed that the method is suitable to evaluate in vivo pre lens tear film stability. From the results, it may be concluded that lens materials with release wetting agents and biocompatible materials can have a positive impact on the patient’s lens wearing experience after 12 hours of wear.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: To evaluate the in vivo tear film stability of three different daily disposable contact lenses (DDCLs) using the ring mire projection of the Keratograph 5M (Oculus) after five minutes, eight hours, and 12 hours of wear.
Methods: Three DDCLs (nelfilcon A, etafilcon A, omafilcon A) were tested on 28 subjects in a prospective, randomised, observer masked cross-over study. From the video recordings, the pre-lens non-invasive keratopgraph-drying-up time (PL NIK-DUT) was determined subjective and the surface wettability graded (0=no visible distortions to 3=distortions in >1/3 of the ring reflection zone) at five, ten, 15, 20 and 25 seconds post-blink after five minutes, eight hours and 12 hours of wear. Medians of PL NIK-DUTs and wettability values of three observers were analysed statistically.
Results: Whereas the PL NIK-DUT was not statistically significantly different between lenses (five min nelfilcon A:4.75±5.36 sec, etafilcon A:5.38±4.50 sec, omafilcon A:6.68±5.00 sec p=0.626; 8 hrs nelfilcon A:5.28±5.71 sec, etafilcon A:3.46±4.52 sec, omafilcon A:4.93±6.34 sec p=0.292; 12 hrs nelfilcon A:5.50±5.43 sec, etafilcon A:4.66± 6.0 sec, omafilcon A:5.85±5.73 sec p=0.614), the subjective wettability grades showed significant differences after 12 hrs with 1.24±1.17 sec for nelfilcon A, 1.43±1.20 sec for etafilcon A and 1.21±1.19 sec for omafilcon A (p=0.001; Kruskal-Wallis-Test).
Conclusion: The study showed that the method is suitable to evaluate in vivo pre lens tear film stability. From the results, it may be concluded that lens materials with release wetting agents and biocompatible materials can have a positive impact on the patient’s lens wearing experience after 12 hours of wear.
Purpose: To evaluate the in vivo tear film stability of three different daily disposable contact lenses (DDCLs) using the ring mire projection of the Keratograph 5M (Oculus) after five minutes, eight hours, and 12 hours of wear.
Methods: Three DDCLs (nelfilcon A, etafilcon A, omafilcon A) were tested on 28 subjects in a prospective, randomised, observer masked cross-over study. From the video recordings, the pre-lens non-invasive keratopgraph-drying-up time (PL NIK-DUT) was determined subjective and the surface wettability graded (0=no visible distortions to 3=distortions in >1/3 of the ring reflection zone) at five, ten, 15, 20 and 25 seconds post-blink after five minutes, eight hours and 12 hours of wear. Medians of PL NIK-DUTs and wettability values of three observers were analysed statistically.
Results: Whereas the PL NIK-DUT was not statistically significantly different between lenses (five min nelfilcon A:4.75±5.36 sec, etafilcon A:5.38±4.50 sec, omafilcon A:6.68±5.00 sec p=0.626; 8 hrs nelfilcon A:5.28±5.71 sec, etafilcon A:3.46±4.52 sec, omafilcon A:4.93±6.34 sec p=0.292; 12 hrs nelfilcon A:5.50±5.43 sec, etafilcon A:4.66± 6.0 sec, omafilcon A:5.85±5.73 sec p=0.614), the subjective wettability grades showed significant differences after 12 hrs with 1.24±1.17 sec for nelfilcon A, 1.43±1.20 sec for etafilcon A and 1.21±1.19 sec for omafilcon A (p=0.001; Kruskal-Wallis-Test).
Conclusion: The study showed that the method is suitable to evaluate in vivo pre lens tear film stability. From the results, it may be concluded that lens materials with release wetting agents and biocompatible materials can have a positive impact on the patient’s lens wearing experience after 12 hours of wear.
Marx, Sebastian; Müller, Christiane; Sickenberger, Wolfgang
BCLA Abstract Book 2014, vol. 38, British Contact Lens Association Elsevier, 2015.
@conference{Marx2015,
title = {Subjective pre-lens tear film stability of daily disposable contact lenses using ring mire projection},
author = {Sebastian Marx and Christiane Müller and Wolfgang Sickenberger},
url = {http://www.sciencedirect.com/science/article/pii/S1367048414002355},
doi = {http://dx.doi.org/10.1016/j.clae.2014.11.096},
year = {2015},
date = {2015-02-01},
urldate = {2015-02-01},
booktitle = {BCLA Abstract Book 2014},
volume = {38},
pages = {e5},
publisher = {Elsevier},
organization = {British Contact Lens Association},
abstract = {Abstract
Purpose: To analyse cross-sectional area (LA) and height of LIPCOF (LH) using a Scheimpflug camera and to evaluate LIPCOF impact on para-central tear meniscus (TM).
Method: Temporal and nasal LIPCOF of 20 subjects (female: 15; median age: 39.4 years) were observed by a slit lamp microscope. A cross-sectional area (LA) and LIPCOF height (LH) was measured using a modified Scheimpflug camera (Oculus, Wetzlar, Germany) at normal eye position, in upward gaze and downward gaze. Para-central TM disruption was analysed by TM fluorescence (TMF). TMF was defined by fluorescence intensity, height and regularity of TM, classified by a 5 grade pictorial scale.
Results: Median temporal LA were 0 m2, 18,867 m2, 52,935 m2, 77,175 m2 (ordered by temporal LIPCOF scores 0–3) and median nasal LA were 4193 m2, 16,378 m2, 57,914 m2, 195,099 m2 (ordered by nasal LIPCOF scores). Median temporal LH were 0 m, 340 m, 410 m, 530 m and median nasal LH were 109 m, 316 m, 614 m, 580 m (ordered by temporal and nasal LIPCOF). Temporal LA was significantly correlated to temporal LIPCOF scores (Spearman rank; r = 0.707, p < 0001), nasal LA was significantly correlated to nasal LIPCOF scores (r = 0.517, p < 0.001). Temporal and nasal LH were significantly correlated to temporal LIPCOF scores (r = 0.700, p < 0001) and nasal LIPCOF scores (r = 0.567, p < 0.001). LH significantly decreased in upwards gaze (ANOVA repeated measurements; p = 0.001) but was unaltered in downward gaze (p = 0.249). In contrast LA was not different between eye positions (p = 0.535). LIPCOF scores, LA and LH were significantly correlated to TMF (temporal: r > 0.731, p < 0.001; nasal: r = 0.609, p < 0.001).
Conclusion: The significant correlations between LA and LH and LIPCOF scores may indicate the usefulness of a modified Scheimpflug camera in the evaluation of LIPCOF. Para-central TM is significantly impacted by LIPCOF. Therefore evaluation of TM volume may be misleading in increased LIPCOF. LH but not LA changed in upward gaze but both were unaltered in downward gaze.},
howpublished = {Poster},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: To analyse cross-sectional area (LA) and height of LIPCOF (LH) using a Scheimpflug camera and to evaluate LIPCOF impact on para-central tear meniscus (TM).
Method: Temporal and nasal LIPCOF of 20 subjects (female: 15; median age: 39.4 years) were observed by a slit lamp microscope. A cross-sectional area (LA) and LIPCOF height (LH) was measured using a modified Scheimpflug camera (Oculus, Wetzlar, Germany) at normal eye position, in upward gaze and downward gaze. Para-central TM disruption was analysed by TM fluorescence (TMF). TMF was defined by fluorescence intensity, height and regularity of TM, classified by a 5 grade pictorial scale.
Results: Median temporal LA were 0 m2, 18,867 m2, 52,935 m2, 77,175 m2 (ordered by temporal LIPCOF scores 0–3) and median nasal LA were 4193 m2, 16,378 m2, 57,914 m2, 195,099 m2 (ordered by nasal LIPCOF scores). Median temporal LH were 0 m, 340 m, 410 m, 530 m and median nasal LH were 109 m, 316 m, 614 m, 580 m (ordered by temporal and nasal LIPCOF). Temporal LA was significantly correlated to temporal LIPCOF scores (Spearman rank; r = 0.707, p < 0001), nasal LA was significantly correlated to nasal LIPCOF scores (r = 0.517, p < 0.001). Temporal and nasal LH were significantly correlated to temporal LIPCOF scores (r = 0.700, p < 0001) and nasal LIPCOF scores (r = 0.567, p < 0.001). LH significantly decreased in upwards gaze (ANOVA repeated measurements; p = 0.001) but was unaltered in downward gaze (p = 0.249). In contrast LA was not different between eye positions (p = 0.535). LIPCOF scores, LA and LH were significantly correlated to TMF (temporal: r > 0.731, p < 0.001; nasal: r = 0.609, p < 0.001).
Conclusion: The significant correlations between LA and LH and LIPCOF scores may indicate the usefulness of a modified Scheimpflug camera in the evaluation of LIPCOF. Para-central TM is significantly impacted by LIPCOF. Therefore evaluation of TM volume may be misleading in increased LIPCOF. LH but not LA changed in upward gaze but both were unaltered in downward gaze.
Purpose: To analyse cross-sectional area (LA) and height of LIPCOF (LH) using a Scheimpflug camera and to evaluate LIPCOF impact on para-central tear meniscus (TM).
Method: Temporal and nasal LIPCOF of 20 subjects (female: 15; median age: 39.4 years) were observed by a slit lamp microscope. A cross-sectional area (LA) and LIPCOF height (LH) was measured using a modified Scheimpflug camera (Oculus, Wetzlar, Germany) at normal eye position, in upward gaze and downward gaze. Para-central TM disruption was analysed by TM fluorescence (TMF). TMF was defined by fluorescence intensity, height and regularity of TM, classified by a 5 grade pictorial scale.
Results: Median temporal LA were 0 m2, 18,867 m2, 52,935 m2, 77,175 m2 (ordered by temporal LIPCOF scores 0–3) and median nasal LA were 4193 m2, 16,378 m2, 57,914 m2, 195,099 m2 (ordered by nasal LIPCOF scores). Median temporal LH were 0 m, 340 m, 410 m, 530 m and median nasal LH were 109 m, 316 m, 614 m, 580 m (ordered by temporal and nasal LIPCOF). Temporal LA was significantly correlated to temporal LIPCOF scores (Spearman rank; r = 0.707, p < 0001), nasal LA was significantly correlated to nasal LIPCOF scores (r = 0.517, p < 0.001). Temporal and nasal LH were significantly correlated to temporal LIPCOF scores (r = 0.700, p < 0001) and nasal LIPCOF scores (r = 0.567, p < 0.001). LH significantly decreased in upwards gaze (ANOVA repeated measurements; p = 0.001) but was unaltered in downward gaze (p = 0.249). In contrast LA was not different between eye positions (p = 0.535). LIPCOF scores, LA and LH were significantly correlated to TMF (temporal: r > 0.731, p < 0.001; nasal: r = 0.609, p < 0.001).
Conclusion: The significant correlations between LA and LH and LIPCOF scores may indicate the usefulness of a modified Scheimpflug camera in the evaluation of LIPCOF. Para-central TM is significantly impacted by LIPCOF. Therefore evaluation of TM volume may be misleading in increased LIPCOF. LH but not LA changed in upward gaze but both were unaltered in downward gaze.
2014
Srinivasan, Sruthi; Pucker, Andrew D.; Jones-Jordan, Lisa A.; Li, Wing; Kwan, Justin T.; Sickenberger, Wolfgang; Marx, Sebastian; Lin, Meng C.; Jones, Lyndon W.
Meibomian Gland Atrophy Rate in Pre-presbyopic Contact Lens and Non-Contact Lens Wearers Conference
no. 140081, American Academy of Optometry 2014.
@conference{Srinivasan2014,
title = {Meibomian Gland Atrophy Rate in Pre-presbyopic Contact Lens and Non-Contact Lens Wearers},
author = {Sruthi Srinivasan and Andrew D. Pucker and Lisa A. Jones-Jordan and Wing Li and Justin T. Kwan and Wolfgang Sickenberger and Sebastian Marx and Meng C. Lin and Lyndon W. Jones},
url = {http://www.aaopt.org/meibomian-gland-atrophy-rate-pre-presbyopic-contact-lens-and-non-contact-lens-wearers},
year = {2014},
date = {2014-11-15},
urldate = {2014-11-15},
number = {140081},
organization = {American Academy of Optometry},
abstract = {Abstract
Purpose: To determine the rate of meibomian gland (MG) atrophy in a matched-pair sample of contact lens (CL) and non-contact-lens (NCL) wearers.
Methods: CL wearers with a minimum of five years of CL use and NCL wearers who were age- and gender-matched were recruited across five study sites from three countries (USA, Canada and Germany). Lower and upper eyelids of all participants were everted and MGs were imaged using the Keratograph 5M infrared camera (OCULUS). MG atrophy (percent) was determined by analyzing the mean gland loss of the upper and lower eyelids in the most affected eye. Digital analyses of the images were conducted using ImageJ software. General linear regression models were used to determine MG atrophy rates in CL and NCL wearers to account for the matched design.
Results:A total of 118 participants were included in the analysis. Mean ± SD age was 28.4 ± 9.9 yrs; 41F and 18M pairs were collected. Mean MG atrophy in the CL group was 25.8% and 24.0% in the NCL group (p=0.41). Neither age (p=0.39) nor gender (p=0.43) was significantly associated with MG atrophy in this cohort. No significant differences were found for different age groups (<20, 20-24, 25-29, 30+ years; p= 0.40). There was a 0.19 % increase per year in MG atrophy in CL wearers compared with a 0.003% increase per year in NCL wearers. Number of years of CL wear was also not significantly associated with MG atrophy (p=0.50).
Conclusions: MG atrophy rates in CL and NCL wearers were similar in this cohort of pre-presbyopic participants. It was also noted that age, gender and years of CL wear were not associated with MG atrophy.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: To determine the rate of meibomian gland (MG) atrophy in a matched-pair sample of contact lens (CL) and non-contact-lens (NCL) wearers.
Methods: CL wearers with a minimum of five years of CL use and NCL wearers who were age- and gender-matched were recruited across five study sites from three countries (USA, Canada and Germany). Lower and upper eyelids of all participants were everted and MGs were imaged using the Keratograph 5M infrared camera (OCULUS). MG atrophy (percent) was determined by analyzing the mean gland loss of the upper and lower eyelids in the most affected eye. Digital analyses of the images were conducted using ImageJ software. General linear regression models were used to determine MG atrophy rates in CL and NCL wearers to account for the matched design.
Results:A total of 118 participants were included in the analysis. Mean ± SD age was 28.4 ± 9.9 yrs; 41F and 18M pairs were collected. Mean MG atrophy in the CL group was 25.8% and 24.0% in the NCL group (p=0.41). Neither age (p=0.39) nor gender (p=0.43) was significantly associated with MG atrophy in this cohort. No significant differences were found for different age groups (<20, 20-24, 25-29, 30+ years; p= 0.40). There was a 0.19 % increase per year in MG atrophy in CL wearers compared with a 0.003% increase per year in NCL wearers. Number of years of CL wear was also not significantly associated with MG atrophy (p=0.50).
Conclusions: MG atrophy rates in CL and NCL wearers were similar in this cohort of pre-presbyopic participants. It was also noted that age, gender and years of CL wear were not associated with MG atrophy.
Purpose: To determine the rate of meibomian gland (MG) atrophy in a matched-pair sample of contact lens (CL) and non-contact-lens (NCL) wearers.
Methods: CL wearers with a minimum of five years of CL use and NCL wearers who were age- and gender-matched were recruited across five study sites from three countries (USA, Canada and Germany). Lower and upper eyelids of all participants were everted and MGs were imaged using the Keratograph 5M infrared camera (OCULUS). MG atrophy (percent) was determined by analyzing the mean gland loss of the upper and lower eyelids in the most affected eye. Digital analyses of the images were conducted using ImageJ software. General linear regression models were used to determine MG atrophy rates in CL and NCL wearers to account for the matched design.
Results:A total of 118 participants were included in the analysis. Mean ± SD age was 28.4 ± 9.9 yrs; 41F and 18M pairs were collected. Mean MG atrophy in the CL group was 25.8% and 24.0% in the NCL group (p=0.41). Neither age (p=0.39) nor gender (p=0.43) was significantly associated with MG atrophy in this cohort. No significant differences were found for different age groups (<20, 20-24, 25-29, 30+ years; p= 0.40). There was a 0.19 % increase per year in MG atrophy in CL wearers compared with a 0.003% increase per year in NCL wearers. Number of years of CL wear was also not significantly associated with MG atrophy (p=0.50).
Conclusions: MG atrophy rates in CL and NCL wearers were similar in this cohort of pre-presbyopic participants. It was also noted that age, gender and years of CL wear were not associated with MG atrophy.
Pucker, Andrew; Jones-Jordan, Lisa; Li, Wing; Kwan, Justin; Lin, Meng; Sickenberger, Wolfgang; Marx, Sebastian; Srinivasan, Sruthi; Jones, Lyndon
Factors Associated with Meibomian Gland Atrophy in Daily Contact Lens Wearers Conference
no. 140082, American Academy of Optometry New Orleans, 2014.
@conference{Pucker2014,
title = {Factors Associated with Meibomian Gland Atrophy in Daily Contact Lens Wearers},
author = {Andrew Pucker and Lisa Jones-Jordan and Wing Li and Justin Kwan and Meng Lin and Wolfgang Sickenberger and Sebastian Marx and Sruthi Srinivasan and Lyndon Jones},
url = {http://www.aaopt.org/factors-associated-meibomian-gland-atrophy-daily-contact-lens-wearers},
year = {2014},
date = {2014-11-15},
urldate = {2014-11-15},
number = {140082},
address = {New Orleans},
organization = {American Academy of Optometry},
abstract = {Abstract
Purpose: To determine factors associated with contact lens related meibomian gland atrophy in a matched pair sample.
Methods: Contact lens wearers (case) and age- and gender-matched non-contact lens wearers with no significant history of contact lens use (control) were recruited across five study sites in three countries. All subjects were administered an Ocular Surface Disease Index (OSDI) questionnaire, and tear meniscus height, non-invasive tear break-up time, tear osmolarity, lid wiper epitheliopathy, lid parallel conjunctival folds, line of Marx, conjunctival staining, upper eyelid meibomian gland expressibility, Schirmer’s test, and meibomian gland atrophy were assessed. Univariate conditional logistic regression was then used to determine relationships between meibomian gland atrophy and clinical signs and symptoms.
Results: Subjects included 118 adults (59 matched pairs). Mean ± SD age was 28.4 ± 9.9 years; 69% of the subjects were female. No significant associations were found between meibomian gland atrophy and the following variables: OSDI (P = 0.55), tear meniscus height (P = 0.85), non-invasive tear break-up time (P = 0.58), tear osmolarity (P = 0.56), lid wiper epitheliopathy (P = 0.34), lid parallel conjunctival folds (P = 0.42), line of Marx (P = 0.32), conjunctival staining (P = 0.36), Schirmer’s test (P = 0.05), and meibomian gland expressibility (P = 0.81). Unpaired analysis comparing subject age and meibomian gland atrophy also found no association.
Conclusions: These data indicate that there are no significant differences between contact lens wearers and non-contact lens wearers in this cohort of relatively young lens wearers, when comparing meibomian gland atrophy to clinical dry eye signs and symptoms. No association between meibomian gland atrophy and age was found, which is in contrast to past studies.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: To determine factors associated with contact lens related meibomian gland atrophy in a matched pair sample.
Methods: Contact lens wearers (case) and age- and gender-matched non-contact lens wearers with no significant history of contact lens use (control) were recruited across five study sites in three countries. All subjects were administered an Ocular Surface Disease Index (OSDI) questionnaire, and tear meniscus height, non-invasive tear break-up time, tear osmolarity, lid wiper epitheliopathy, lid parallel conjunctival folds, line of Marx, conjunctival staining, upper eyelid meibomian gland expressibility, Schirmer’s test, and meibomian gland atrophy were assessed. Univariate conditional logistic regression was then used to determine relationships between meibomian gland atrophy and clinical signs and symptoms.
Results: Subjects included 118 adults (59 matched pairs). Mean ± SD age was 28.4 ± 9.9 years; 69% of the subjects were female. No significant associations were found between meibomian gland atrophy and the following variables: OSDI (P = 0.55), tear meniscus height (P = 0.85), non-invasive tear break-up time (P = 0.58), tear osmolarity (P = 0.56), lid wiper epitheliopathy (P = 0.34), lid parallel conjunctival folds (P = 0.42), line of Marx (P = 0.32), conjunctival staining (P = 0.36), Schirmer’s test (P = 0.05), and meibomian gland expressibility (P = 0.81). Unpaired analysis comparing subject age and meibomian gland atrophy also found no association.
Conclusions: These data indicate that there are no significant differences between contact lens wearers and non-contact lens wearers in this cohort of relatively young lens wearers, when comparing meibomian gland atrophy to clinical dry eye signs and symptoms. No association between meibomian gland atrophy and age was found, which is in contrast to past studies.
Purpose: To determine factors associated with contact lens related meibomian gland atrophy in a matched pair sample.
Methods: Contact lens wearers (case) and age- and gender-matched non-contact lens wearers with no significant history of contact lens use (control) were recruited across five study sites in three countries. All subjects were administered an Ocular Surface Disease Index (OSDI) questionnaire, and tear meniscus height, non-invasive tear break-up time, tear osmolarity, lid wiper epitheliopathy, lid parallel conjunctival folds, line of Marx, conjunctival staining, upper eyelid meibomian gland expressibility, Schirmer’s test, and meibomian gland atrophy were assessed. Univariate conditional logistic regression was then used to determine relationships between meibomian gland atrophy and clinical signs and symptoms.
Results: Subjects included 118 adults (59 matched pairs). Mean ± SD age was 28.4 ± 9.9 years; 69% of the subjects were female. No significant associations were found between meibomian gland atrophy and the following variables: OSDI (P = 0.55), tear meniscus height (P = 0.85), non-invasive tear break-up time (P = 0.58), tear osmolarity (P = 0.56), lid wiper epitheliopathy (P = 0.34), lid parallel conjunctival folds (P = 0.42), line of Marx (P = 0.32), conjunctival staining (P = 0.36), Schirmer’s test (P = 0.05), and meibomian gland expressibility (P = 0.81). Unpaired analysis comparing subject age and meibomian gland atrophy also found no association.
Conclusions: These data indicate that there are no significant differences between contact lens wearers and non-contact lens wearers in this cohort of relatively young lens wearers, when comparing meibomian gland atrophy to clinical dry eye signs and symptoms. No association between meibomian gland atrophy and age was found, which is in contrast to past studies.
Marx, Sebastian; Schwarz, Stefan; Fahmy, Mary; Kern, Jami; Maissa, Cecile
Subjective performance of hydrogel and silicone hydrogel daily disposable contact lenses Conference
no. 145191, American Academy of Optometry 2014.
@conference{Marx2014,
title = {Subjective performance of hydrogel and silicone hydrogel daily disposable contact lenses},
author = {Sebastian Marx and Stefan Schwarz and Mary Fahmy and Jami Kern and Cecile Maissa},
url = {https://www.jenvis-research.com/wp-content/uploads/2017/09/Subjective-performance-of-hydrogel-and-silicone-hydrogel-AAO-POSTER-2014-1.pdf
http://www.aaopt.org/subjective-performance-hydrogel-and-silicone-hydrogel-daily-disposable-contact-lenses},
year = {2014},
date = {2014-11-14},
urldate = {2014-11-14},
number = {145191},
organization = {American Academy of Optometry},
abstract = {Abstract
Purpose: The purpose of this study was to evaluate subjective performance of DAILIES® AquaComfort Plus™ (nelfilcon A with 69% water content and a blink-activated moisture system; Alcon Laboratories, Inc.) and Clariti™ 1-day (Alcon II-3 with 56% water content; Saufon Pharmaceuticals) in a population of daily disposable (DD) contact lens wearers
Methods: In a subject-masked multi-center cross-over study, current DD wearers (n=316) wore the test (nelfilcon A) or control (filcon II-3) lenses bilaterally for 1 week each, in a randomized order.The subjective performance was recorded in terms of subjective ratings and preferences for comfort, dryness, vision, handling, overall satisfaction/overall preference and purchase intent.The subjects rated their subjective responses on a 1-10 point scale (1=poor/very dry/difficult, 10=excellent/not dry/easy).
Results: 316 subjects, all habitual wearers of spherical DD lenses, were enrolled at twenty two (22) sites (6 UK sites 16 German sites), 310 completed the study. After 1 week of wear, the performance of the test lenses was unsurpassed for all subjective ratings of comfort, dryness, handling, and vision compared to the control lenses. In addition, comfort during the day was significantly superior for the test lens compared to the control lens (8.0 v 7.6; <0.001). The test lenses were also shown to be superior to the control lenses for dryness throughout the day (7.7 v 7.3), handling at removal (8.0 v 7.5), all vision ratings (quality of vision during the day: 8.5 v 7.5 , quality of vision at night: 8.1 v 7.2, consistency of vision throughout the day: 8.1 v 7.2, consistency of vision at night: 8.0 v 7.3, consistency of vision from day to day: 8.6 v 8.0, and overall vision quality: 8.3 v 7.4) and overall lens satisfaction (7.8 v 6.9 p<0.001). Finally, among subjects with a preference, the test lenses were preferred for comfort during the day, comfort at the end of the day, overall comfort, overall vision, overall preference, and purchase intent (p<0.001 to 0.006).
Conclusion:The two DD lenses were well accepted, with the nelfilcon A lenses showing superior daytime comfort, handling at removal, overall lens satisfaction and all vision ratings and less dryness throughout the day when compared with the filcon II-3 lenses after one week of wear.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: The purpose of this study was to evaluate subjective performance of DAILIES® AquaComfort Plus™ (nelfilcon A with 69% water content and a blink-activated moisture system; Alcon Laboratories, Inc.) and Clariti™ 1-day (Alcon II-3 with 56% water content; Saufon Pharmaceuticals) in a population of daily disposable (DD) contact lens wearers
Methods: In a subject-masked multi-center cross-over study, current DD wearers (n=316) wore the test (nelfilcon A) or control (filcon II-3) lenses bilaterally for 1 week each, in a randomized order.The subjective performance was recorded in terms of subjective ratings and preferences for comfort, dryness, vision, handling, overall satisfaction/overall preference and purchase intent.The subjects rated their subjective responses on a 1-10 point scale (1=poor/very dry/difficult, 10=excellent/not dry/easy).
Results: 316 subjects, all habitual wearers of spherical DD lenses, were enrolled at twenty two (22) sites (6 UK sites 16 German sites), 310 completed the study. After 1 week of wear, the performance of the test lenses was unsurpassed for all subjective ratings of comfort, dryness, handling, and vision compared to the control lenses. In addition, comfort during the day was significantly superior for the test lens compared to the control lens (8.0 v 7.6; <0.001). The test lenses were also shown to be superior to the control lenses for dryness throughout the day (7.7 v 7.3), handling at removal (8.0 v 7.5), all vision ratings (quality of vision during the day: 8.5 v 7.5 , quality of vision at night: 8.1 v 7.2, consistency of vision throughout the day: 8.1 v 7.2, consistency of vision at night: 8.0 v 7.3, consistency of vision from day to day: 8.6 v 8.0, and overall vision quality: 8.3 v 7.4) and overall lens satisfaction (7.8 v 6.9 p<0.001). Finally, among subjects with a preference, the test lenses were preferred for comfort during the day, comfort at the end of the day, overall comfort, overall vision, overall preference, and purchase intent (p<0.001 to 0.006).
Conclusion:The two DD lenses were well accepted, with the nelfilcon A lenses showing superior daytime comfort, handling at removal, overall lens satisfaction and all vision ratings and less dryness throughout the day when compared with the filcon II-3 lenses after one week of wear.
Purpose: The purpose of this study was to evaluate subjective performance of DAILIES® AquaComfort Plus™ (nelfilcon A with 69% water content and a blink-activated moisture system; Alcon Laboratories, Inc.) and Clariti™ 1-day (Alcon II-3 with 56% water content; Saufon Pharmaceuticals) in a population of daily disposable (DD) contact lens wearers
Methods: In a subject-masked multi-center cross-over study, current DD wearers (n=316) wore the test (nelfilcon A) or control (filcon II-3) lenses bilaterally for 1 week each, in a randomized order.The subjective performance was recorded in terms of subjective ratings and preferences for comfort, dryness, vision, handling, overall satisfaction/overall preference and purchase intent.The subjects rated their subjective responses on a 1-10 point scale (1=poor/very dry/difficult, 10=excellent/not dry/easy).
Results: 316 subjects, all habitual wearers of spherical DD lenses, were enrolled at twenty two (22) sites (6 UK sites 16 German sites), 310 completed the study. After 1 week of wear, the performance of the test lenses was unsurpassed for all subjective ratings of comfort, dryness, handling, and vision compared to the control lenses. In addition, comfort during the day was significantly superior for the test lens compared to the control lens (8.0 v 7.6; <0.001). The test lenses were also shown to be superior to the control lenses for dryness throughout the day (7.7 v 7.3), handling at removal (8.0 v 7.5), all vision ratings (quality of vision during the day: 8.5 v 7.5 , quality of vision at night: 8.1 v 7.2, consistency of vision throughout the day: 8.1 v 7.2, consistency of vision at night: 8.0 v 7.3, consistency of vision from day to day: 8.6 v 8.0, and overall vision quality: 8.3 v 7.4) and overall lens satisfaction (7.8 v 6.9 p<0.001). Finally, among subjects with a preference, the test lenses were preferred for comfort during the day, comfort at the end of the day, overall comfort, overall vision, overall preference, and purchase intent (p<0.001 to 0.006).
Conclusion:The two DD lenses were well accepted, with the nelfilcon A lenses showing superior daytime comfort, handling at removal, overall lens satisfaction and all vision ratings and less dryness throughout the day when compared with the filcon II-3 lenses after one week of wear.
Schubert, Sebastian; Rehnert, Mario; Sickenberger, Wolfgang
Development and Evaluation of a novel Tool to measure the pupillary and contact lens decentration Conference
no. 145227, American Academy of Optometry 2014.
@conference{Schubert2014,
title = {Development and Evaluation of a novel Tool to measure the pupillary and contact lens decentration},
author = {Sebastian Schubert and Mario Rehnert and Wolfgang Sickenberger},
url = {https://www.jenvis-research.com/wp-content/uploads/2017/09/AAO-2014-SS-Development-and-Evaluation-of-a-novel-to.pdf
http://www.aaopt.org/development-and-evaluation-novel-tool-measure-pupillary-and-contact-lens-decentration},
year = {2014},
date = {2014-11-14},
urldate = {2014-11-14},
number = {145227},
organization = {American Academy of Optometry},
abstract = {Abstract
Purpose: To develop a novel tool to measure the difference between the corneal and the pupillary center as well as difference between the pupillary and the contact lens center based on a photograph of the anterior eye captured with a conventional slit lamp.
Methods: The novel tool to measure the distances was developed as a double-triangle. To evaluate the center of the pupillary, the cornea or the CL, a photograph of the eye was taken with a conventional video slit lamp. Then, the double-triangle was masked on the photograph of the eye. To find the position at least three of four edges of the triangle must touch the edge of the pupillary, the cornea and the CL. To determine the difference between the centers, the distance between the triangle centers were measured. To evaluate the tool a prospective study by means of a conventional video slit lamp and a SIRIUS - 3D Rotating Scheimpflug Camera & Topography System (bon optic) in 20 subjects (50% male; aged (54.9±6.3 years with a range of (45 to 71) years) was conducted. The differences between the pupillary center and the corneal vertex were measured with both devices.
Results: The pupillary decentration by means of the novel tool was measured by OD -0.24±0.13mm and OS -0.33±0.14mm and by means of the Rotating Scheimpflug Camera by OD -0.18±0.11mm und OS -0.21±0.12mm. Comparing both methods the mean differences were OD 0.06±0.02mm and OS 0.12±0.02mm.
Conclusion: The novel measuring tool combines the advantages of the conventional graticule and software based analyzing tools like modern video topographer. Especially for fitting simultaneous contact lenses, the difference between the CL center and pupillary center can be visualized and measured easily. Furthermore, the tool could be used for similar tasks, e.g. measuring intra ocular lens decentration.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: To develop a novel tool to measure the difference between the corneal and the pupillary center as well as difference between the pupillary and the contact lens center based on a photograph of the anterior eye captured with a conventional slit lamp.
Methods: The novel tool to measure the distances was developed as a double-triangle. To evaluate the center of the pupillary, the cornea or the CL, a photograph of the eye was taken with a conventional video slit lamp. Then, the double-triangle was masked on the photograph of the eye. To find the position at least three of four edges of the triangle must touch the edge of the pupillary, the cornea and the CL. To determine the difference between the centers, the distance between the triangle centers were measured. To evaluate the tool a prospective study by means of a conventional video slit lamp and a SIRIUS - 3D Rotating Scheimpflug Camera & Topography System (bon optic) in 20 subjects (50% male; aged (54.9±6.3 years with a range of (45 to 71) years) was conducted. The differences between the pupillary center and the corneal vertex were measured with both devices.
Results: The pupillary decentration by means of the novel tool was measured by OD -0.24±0.13mm and OS -0.33±0.14mm and by means of the Rotating Scheimpflug Camera by OD -0.18±0.11mm und OS -0.21±0.12mm. Comparing both methods the mean differences were OD 0.06±0.02mm and OS 0.12±0.02mm.
Conclusion: The novel measuring tool combines the advantages of the conventional graticule and software based analyzing tools like modern video topographer. Especially for fitting simultaneous contact lenses, the difference between the CL center and pupillary center can be visualized and measured easily. Furthermore, the tool could be used for similar tasks, e.g. measuring intra ocular lens decentration.
Purpose: To develop a novel tool to measure the difference between the corneal and the pupillary center as well as difference between the pupillary and the contact lens center based on a photograph of the anterior eye captured with a conventional slit lamp.
Methods: The novel tool to measure the distances was developed as a double-triangle. To evaluate the center of the pupillary, the cornea or the CL, a photograph of the eye was taken with a conventional video slit lamp. Then, the double-triangle was masked on the photograph of the eye. To find the position at least three of four edges of the triangle must touch the edge of the pupillary, the cornea and the CL. To determine the difference between the centers, the distance between the triangle centers were measured. To evaluate the tool a prospective study by means of a conventional video slit lamp and a SIRIUS - 3D Rotating Scheimpflug Camera & Topography System (bon optic) in 20 subjects (50% male; aged (54.9±6.3 years with a range of (45 to 71) years) was conducted. The differences between the pupillary center and the corneal vertex were measured with both devices.
Results: The pupillary decentration by means of the novel tool was measured by OD -0.24±0.13mm and OS -0.33±0.14mm and by means of the Rotating Scheimpflug Camera by OD -0.18±0.11mm und OS -0.21±0.12mm. Comparing both methods the mean differences were OD 0.06±0.02mm and OS 0.12±0.02mm.
Conclusion: The novel measuring tool combines the advantages of the conventional graticule and software based analyzing tools like modern video topographer. Especially for fitting simultaneous contact lenses, the difference between the CL center and pupillary center can be visualized and measured easily. Furthermore, the tool could be used for similar tasks, e.g. measuring intra ocular lens decentration.
Blaurock, Claudia; Oehring, Daniela; Sickenberger, Wolfgang
no. 145226, American Academy of Optometry 2014.
@conference{Blaurock2017,
title = {Standard values of the central corneal curvature and eccentricity in healthy Caucasian eyes: a retrospective study },
author = {Claudia Blaurock and Daniela Oehring and Wolfgang Sickenberger },
url = {http://www.aaopt.org/standard-values-central-corneal-curvature-and-eccentricity-healthy-caucasian-eyes-retrospective},
year = {2014},
date = {2014-11-14},
urldate = {2014-11-14},
number = {145226},
organization = {American Academy of Optometry},
abstract = {Abstract
Purpose: Corneal curvature (cc) and eccentricity is a standard method to describe the topography of the eye. The cc has an impact on the measurements of the dynamic contour tonometry. The values of the cc are fundamentally important for all kind of refractive surgery and IOL power calculation. Curvature changes are associated with a large number of corneal diseases and contact lens wearing. The purpose of the study was to evaluate standard values of the central corneal curvature and the 30-degree eccentricity (Ecc).
Methods: The central corneal radii (flattest K1 and steepest K2) and the eccentricity within 30deg were measured by means of the multifunctional topographer (Keratograph 4 Oculus, Germany). After applying the exclusion criteria and outlier labeling 4,360 right and 4,308 left eyes of 4,505 healthy Caucasian subjects were analyzed. The subjects were aged between 0-113years (mean 36.23±16.89 years). If there were more than one value for each eye available the average was calculated. Gender distribution shows 39.4% males. Differences between male and female as well as between the right and the left eye were analyzed (Shapiro-Wilk test, correlation between cc and age by means of Pearsons r).
Results: The mean corneal radii at 30deg are 43.03±1.50dpt and 44.08±1,57dpt for the K1 and the K2, respectively. The data shows a statistically significant difference between males and females (t-test, p= 0.000; K1/ K2: male 42.68±1.53dpt/ 43.68±1.58dpt, female 43.27±1.46dpt/ 44.34±1.52dpt). The mean corneal eccentricity at 30deg was 0.55±0.10. For none of the analyzed data a correlation to the age was found (K1 p=0.005; K2 p=-0.033; Ecc p=-0.026).
Conclusion: The mean cc and the eccentricity at 30deg provided by a multifunctional topographer are related to the reported average values for Caucasian subjects. The central corneal radius is lager in males than in females. The same ratios were found for the eccentricity at 30 deg. The values of the cc are relevant for the calculation of contact lenses, dynamic counter tonometry and corneal surgery. },
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: Corneal curvature (cc) and eccentricity is a standard method to describe the topography of the eye. The cc has an impact on the measurements of the dynamic contour tonometry. The values of the cc are fundamentally important for all kind of refractive surgery and IOL power calculation. Curvature changes are associated with a large number of corneal diseases and contact lens wearing. The purpose of the study was to evaluate standard values of the central corneal curvature and the 30-degree eccentricity (Ecc).
Methods: The central corneal radii (flattest K1 and steepest K2) and the eccentricity within 30deg were measured by means of the multifunctional topographer (Keratograph 4 Oculus, Germany). After applying the exclusion criteria and outlier labeling 4,360 right and 4,308 left eyes of 4,505 healthy Caucasian subjects were analyzed. The subjects were aged between 0-113years (mean 36.23±16.89 years). If there were more than one value for each eye available the average was calculated. Gender distribution shows 39.4% males. Differences between male and female as well as between the right and the left eye were analyzed (Shapiro-Wilk test, correlation between cc and age by means of Pearsons r).
Results: The mean corneal radii at 30deg are 43.03±1.50dpt and 44.08±1,57dpt for the K1 and the K2, respectively. The data shows a statistically significant difference between males and females (t-test, p= 0.000; K1/ K2: male 42.68±1.53dpt/ 43.68±1.58dpt, female 43.27±1.46dpt/ 44.34±1.52dpt). The mean corneal eccentricity at 30deg was 0.55±0.10. For none of the analyzed data a correlation to the age was found (K1 p=0.005; K2 p=-0.033; Ecc p=-0.026).
Conclusion: The mean cc and the eccentricity at 30deg provided by a multifunctional topographer are related to the reported average values for Caucasian subjects. The central corneal radius is lager in males than in females. The same ratios were found for the eccentricity at 30 deg. The values of the cc are relevant for the calculation of contact lenses, dynamic counter tonometry and corneal surgery.
Purpose: Corneal curvature (cc) and eccentricity is a standard method to describe the topography of the eye. The cc has an impact on the measurements of the dynamic contour tonometry. The values of the cc are fundamentally important for all kind of refractive surgery and IOL power calculation. Curvature changes are associated with a large number of corneal diseases and contact lens wearing. The purpose of the study was to evaluate standard values of the central corneal curvature and the 30-degree eccentricity (Ecc).
Methods: The central corneal radii (flattest K1 and steepest K2) and the eccentricity within 30deg were measured by means of the multifunctional topographer (Keratograph 4 Oculus, Germany). After applying the exclusion criteria and outlier labeling 4,360 right and 4,308 left eyes of 4,505 healthy Caucasian subjects were analyzed. The subjects were aged between 0-113years (mean 36.23±16.89 years). If there were more than one value for each eye available the average was calculated. Gender distribution shows 39.4% males. Differences between male and female as well as between the right and the left eye were analyzed (Shapiro-Wilk test, correlation between cc and age by means of Pearsons r).
Results: The mean corneal radii at 30deg are 43.03±1.50dpt and 44.08±1,57dpt for the K1 and the K2, respectively. The data shows a statistically significant difference between males and females (t-test, p= 0.000; K1/ K2: male 42.68±1.53dpt/ 43.68±1.58dpt, female 43.27±1.46dpt/ 44.34±1.52dpt). The mean corneal eccentricity at 30deg was 0.55±0.10. For none of the analyzed data a correlation to the age was found (K1 p=0.005; K2 p=-0.033; Ecc p=-0.026).
Conclusion: The mean cc and the eccentricity at 30deg provided by a multifunctional topographer are related to the reported average values for Caucasian subjects. The central corneal radius is lager in males than in females. The same ratios were found for the eccentricity at 30 deg. The values of the cc are relevant for the calculation of contact lenses, dynamic counter tonometry and corneal surgery.
Amthor, Bianca; Marx, Sebastian; Sickenberger, Wolfgang
no. 145022, American Academy of Optometry 2014.
@conference{Amthor2014,
title = {Study to measure the tear film stabilisation and possible reduction of subjective symptoms by application of lipid-containing lubricants},
author = {Bianca Amthor and Sebastian Marx and Wolfgang Sickenberger},
url = {https://www.jenvis-research.com/wp-content/uploads/2017/09/AAO-2014-Study-to-measure-the-tear-film-stabilisation-and-possible-reduction-of-subjective-symptoms-by-application-of-lipid-containing-lubricants-BA-SM.pdf
http://www.aaopt.org/study-measure-tear-film-stabilisation-and-possible-reduction-subjective-symptoms-application-lipid},
year = {2014},
date = {2014-11-13},
urldate = {2014-11-13},
number = {145022},
organization = {American Academy of Optometry},
abstract = {Abstract
Purpose: The aim of the thesis was to investigate if the application of lipid-containing lubricants can have a positive effect on the stabilisation of the tear film. Furthermore, the consistency between patients perception and stabilisation of the tear film were evaluated.
Methods: The study involved 24 patients (n = 24; with an average age of 59 +/-9 years; 66.7 % female and 33.3 % male patients). Quality and quantity tear film tests to the right eye were performed by using the K5M (Videokeratograph, Oculus) and a slit lamp (SL120, Zeiss). On each appointment a questionnaire was completed by the patient. Three appointments at a distance between 12-16 days were performed apart and the distribution of lubricants was random.
Results: The results of the NIK-BUT-measurement were normally distributed and there was no significant difference between the lubricants. An impact of both lubricant compounds has been demonstrated, it applies to both short term and long term effects. For the first group of subjects the NIK-BUT values for the baseline take place at 11.9 +/- 4.9 seconds. At the final test the NIK-BUT is 14.1 +/- 5.5 seconds. For the second group of subjects the NIK-BUT values take place to 10.4 +/- 6.1 seconds at the baseline test and for the finish test they take place at 14.3 +/-6.3 seconds.
There was a huge discrepancy between NIK-BUT-classifications and the OSDI-scores. For the tear meniscus height and OSDI-score no consistency could be demonstrated.
Conclusions: Lipid-containing lubricants lead a stabilisation of the tear film, regardless of their form of application.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: The aim of the thesis was to investigate if the application of lipid-containing lubricants can have a positive effect on the stabilisation of the tear film. Furthermore, the consistency between patients perception and stabilisation of the tear film were evaluated.
Methods: The study involved 24 patients (n = 24; with an average age of 59 +/-9 years; 66.7 % female and 33.3 % male patients). Quality and quantity tear film tests to the right eye were performed by using the K5M (Videokeratograph, Oculus) and a slit lamp (SL120, Zeiss). On each appointment a questionnaire was completed by the patient. Three appointments at a distance between 12-16 days were performed apart and the distribution of lubricants was random.
Results: The results of the NIK-BUT-measurement were normally distributed and there was no significant difference between the lubricants. An impact of both lubricant compounds has been demonstrated, it applies to both short term and long term effects. For the first group of subjects the NIK-BUT values for the baseline take place at 11.9 +/- 4.9 seconds. At the final test the NIK-BUT is 14.1 +/- 5.5 seconds. For the second group of subjects the NIK-BUT values take place to 10.4 +/- 6.1 seconds at the baseline test and for the finish test they take place at 14.3 +/-6.3 seconds.
There was a huge discrepancy between NIK-BUT-classifications and the OSDI-scores. For the tear meniscus height and OSDI-score no consistency could be demonstrated.
Conclusions: Lipid-containing lubricants lead a stabilisation of the tear film, regardless of their form of application.
Purpose: The aim of the thesis was to investigate if the application of lipid-containing lubricants can have a positive effect on the stabilisation of the tear film. Furthermore, the consistency between patients perception and stabilisation of the tear film were evaluated.
Methods: The study involved 24 patients (n = 24; with an average age of 59 +/-9 years; 66.7 % female and 33.3 % male patients). Quality and quantity tear film tests to the right eye were performed by using the K5M (Videokeratograph, Oculus) and a slit lamp (SL120, Zeiss). On each appointment a questionnaire was completed by the patient. Three appointments at a distance between 12-16 days were performed apart and the distribution of lubricants was random.
Results: The results of the NIK-BUT-measurement were normally distributed and there was no significant difference between the lubricants. An impact of both lubricant compounds has been demonstrated, it applies to both short term and long term effects. For the first group of subjects the NIK-BUT values for the baseline take place at 11.9 +/- 4.9 seconds. At the final test the NIK-BUT is 14.1 +/- 5.5 seconds. For the second group of subjects the NIK-BUT values take place to 10.4 +/- 6.1 seconds at the baseline test and for the finish test they take place at 14.3 +/-6.3 seconds.
There was a huge discrepancy between NIK-BUT-classifications and the OSDI-scores. For the tear meniscus height and OSDI-score no consistency could be demonstrated.
Conclusions: Lipid-containing lubricants lead a stabilisation of the tear film, regardless of their form of application.
Oehring, Daniela; Sickenberger, Wolfgang
no. 145029, American Academy of Optometry 2014.
@conference{Oehring2014,
title = {Prospective Study to compare two different Kinds of Illuminations by Measuring the Non-Invasive Tear Film Break-Up Time by Means of a Video Topographer},
author = {Daniela Oehring and Wolfgang Sickenberger},
url = {http://www.aaopt.org/prospective-study-compare-two-different-kinds-illuminations-measuring-non-invasive-tear-film-break},
year = {2014},
date = {2014-11-13},
urldate = {2014-11-13},
number = {145029},
organization = {American Academy of Optometry},
abstract = {Abstract
Purpose: To determine differences between two different illuminations, white light and infrared, which are available when measuring the non-invasive tear film break-up time (NIK-BUT) using a novel video topographer.
Methods: A single-center, three-visit, randomized, prospective study evaluating the NIK-BUT measured by means of an objective analyzing software of the video topographer was conducted in 37 subjects (56% male; aged (31.5+/-10.3)years (19-65 years). The NIK-BUT was measured on both eyes in randomized order with white (W) and infrared (IR) illumination, consecutively three times at each visit and at the same daytime under standardized conditions. To compare these illuminations both available BUT values, first BUT (FBUT) and average BUT (AvgBUT), as well as measurement time and the maximal area of the tear film break-up (represented by the weighted amount of affected segments) were analyzed. To determine inter-group comparisons, a two-tailed t-test was conducted.
Results: The white illumination (467 measurements) shows the average FBUT at (6.44+/-5.34)sec and AvgBUT at (9.55+/-5.48)sec. The measurement time was on average (18.04+/-6.86)sec and the maximal area was (2.6+/-3.5)segments. With infrared (374 measurements) the average FBUT was determined at (6.25+/-4.59)sec, AvgBUT at (8.78+/-4.78)sec. The measurement time was on average (18.18+/-6.90)sec and the maximal area was (2.7+/-3.7)segments. There were no statistically significant differences between white and infrared illumination in each measured variable (FBUT p=0.959; AvgBUT p=0,160; measurement time p=0.998; maximal area 0.360; two-tailed t-test).
Conclusions: There are no significant differences between both available illuminations when measuring the NIK-BUT with the K5 video topographer (Oculus). Therefore the investigator is independent in choosing the illumination. Only the patient preferences and conditions may affect this choice. Additionally, both kinds of measurements are assignable.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: To determine differences between two different illuminations, white light and infrared, which are available when measuring the non-invasive tear film break-up time (NIK-BUT) using a novel video topographer.
Methods: A single-center, three-visit, randomized, prospective study evaluating the NIK-BUT measured by means of an objective analyzing software of the video topographer was conducted in 37 subjects (56% male; aged (31.5+/-10.3)years (19-65 years). The NIK-BUT was measured on both eyes in randomized order with white (W) and infrared (IR) illumination, consecutively three times at each visit and at the same daytime under standardized conditions. To compare these illuminations both available BUT values, first BUT (FBUT) and average BUT (AvgBUT), as well as measurement time and the maximal area of the tear film break-up (represented by the weighted amount of affected segments) were analyzed. To determine inter-group comparisons, a two-tailed t-test was conducted.
Results: The white illumination (467 measurements) shows the average FBUT at (6.44+/-5.34)sec and AvgBUT at (9.55+/-5.48)sec. The measurement time was on average (18.04+/-6.86)sec and the maximal area was (2.6+/-3.5)segments. With infrared (374 measurements) the average FBUT was determined at (6.25+/-4.59)sec, AvgBUT at (8.78+/-4.78)sec. The measurement time was on average (18.18+/-6.90)sec and the maximal area was (2.7+/-3.7)segments. There were no statistically significant differences between white and infrared illumination in each measured variable (FBUT p=0.959; AvgBUT p=0,160; measurement time p=0.998; maximal area 0.360; two-tailed t-test).
Conclusions: There are no significant differences between both available illuminations when measuring the NIK-BUT with the K5 video topographer (Oculus). Therefore the investigator is independent in choosing the illumination. Only the patient preferences and conditions may affect this choice. Additionally, both kinds of measurements are assignable.
Purpose: To determine differences between two different illuminations, white light and infrared, which are available when measuring the non-invasive tear film break-up time (NIK-BUT) using a novel video topographer.
Methods: A single-center, three-visit, randomized, prospective study evaluating the NIK-BUT measured by means of an objective analyzing software of the video topographer was conducted in 37 subjects (56% male; aged (31.5+/-10.3)years (19-65 years). The NIK-BUT was measured on both eyes in randomized order with white (W) and infrared (IR) illumination, consecutively three times at each visit and at the same daytime under standardized conditions. To compare these illuminations both available BUT values, first BUT (FBUT) and average BUT (AvgBUT), as well as measurement time and the maximal area of the tear film break-up (represented by the weighted amount of affected segments) were analyzed. To determine inter-group comparisons, a two-tailed t-test was conducted.
Results: The white illumination (467 measurements) shows the average FBUT at (6.44+/-5.34)sec and AvgBUT at (9.55+/-5.48)sec. The measurement time was on average (18.04+/-6.86)sec and the maximal area was (2.6+/-3.5)segments. With infrared (374 measurements) the average FBUT was determined at (6.25+/-4.59)sec, AvgBUT at (8.78+/-4.78)sec. The measurement time was on average (18.18+/-6.90)sec and the maximal area was (2.7+/-3.7)segments. There were no statistically significant differences between white and infrared illumination in each measured variable (FBUT p=0.959; AvgBUT p=0,160; measurement time p=0.998; maximal area 0.360; two-tailed t-test).
Conclusions: There are no significant differences between both available illuminations when measuring the NIK-BUT with the K5 video topographer (Oculus). Therefore the investigator is independent in choosing the illumination. Only the patient preferences and conditions may affect this choice. Additionally, both kinds of measurements are assignable.
Henker, Eric; Kolbe, Oliver; Sickenberger, Wolfgang
no. 145159, American Academy of Optometry 2014.
@conference{Henker2014,
title = {Development of a new display based testing method for the measurement of the dynamic visual acuity (DVA)},
author = {Eric Henker and Oliver Kolbe and Wolfgang Sickenberger},
url = {http://www.aaopt.org/development-new-display-based-testing-method-measurement-dynamic-visual-acuity-dva
https://www.jenvis-research.com/wp-content/uploads/2016/07/Poster-AAO_DVA_2_klein.pdf},
year = {2014},
date = {2014-11-13},
urldate = {2014-11-13},
number = {145159},
organization = {American Academy of Optometry},
abstract = {Abstract
Purpose: The dynamic visual acuity (DVA) defines the ability to detect details in moving objects. Available digital testing devices suffer from a poor display performance, such as motion blur and afterimages. Considering the technological progress of visual display units a new, standardized testing method for the measurement of the DVA should be achieved.
Methods: A market analysis and a feasibility analysis clarified if the display performance of modern VDUs last the demands of a reliable test. Different possibilities of the presentation of optotypes were tested experimentally, several coding languages compared.
Results: Presenting moving objects in an acceptable display performance is realizable with the Foris FG2421 (Eizo) display unit (23.5”) using the 240 Hz turbo mode. A refresh rate of 120 Hz combined with blinking backlight (240 Hz turbo mode) guarantees great motion clarity and not notable afterimages. The foundation for a standardized test procedure was developed based on the testing method for the static visual acuity. Five moving optotypes (Landolt C) are presented on a sphere for each velocity level and size for a fixed presentation time of each 2 seconds. The starting point, the direction of movement (clockwise, counterclockwise) as well as the gap of the Landolt C is randomized. The test is measuring in the range of the smooth pursuit eye movements. The test scenarios are programmed with Flash CS 6 and transformed into single video clips. The field of view is limited by the screen size, display resolution and computer performance.
Conclusions: Due to the technological progress DVA measurements could be realized using VDUs. The new standardized testing method needs to be enhanced. Further studies should determine defined velocities and sizes of the moving objects. The test should be recoded in C++ to minimize the randomization and presentation effort and to lower the required computer performance. A validation study should be run as well as new technologies (4K, HDMI 2.0) observed.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: The dynamic visual acuity (DVA) defines the ability to detect details in moving objects. Available digital testing devices suffer from a poor display performance, such as motion blur and afterimages. Considering the technological progress of visual display units a new, standardized testing method for the measurement of the DVA should be achieved.
Methods: A market analysis and a feasibility analysis clarified if the display performance of modern VDUs last the demands of a reliable test. Different possibilities of the presentation of optotypes were tested experimentally, several coding languages compared.
Results: Presenting moving objects in an acceptable display performance is realizable with the Foris FG2421 (Eizo) display unit (23.5”) using the 240 Hz turbo mode. A refresh rate of 120 Hz combined with blinking backlight (240 Hz turbo mode) guarantees great motion clarity and not notable afterimages. The foundation for a standardized test procedure was developed based on the testing method for the static visual acuity. Five moving optotypes (Landolt C) are presented on a sphere for each velocity level and size for a fixed presentation time of each 2 seconds. The starting point, the direction of movement (clockwise, counterclockwise) as well as the gap of the Landolt C is randomized. The test is measuring in the range of the smooth pursuit eye movements. The test scenarios are programmed with Flash CS 6 and transformed into single video clips. The field of view is limited by the screen size, display resolution and computer performance.
Conclusions: Due to the technological progress DVA measurements could be realized using VDUs. The new standardized testing method needs to be enhanced. Further studies should determine defined velocities and sizes of the moving objects. The test should be recoded in C++ to minimize the randomization and presentation effort and to lower the required computer performance. A validation study should be run as well as new technologies (4K, HDMI 2.0) observed.
Purpose: The dynamic visual acuity (DVA) defines the ability to detect details in moving objects. Available digital testing devices suffer from a poor display performance, such as motion blur and afterimages. Considering the technological progress of visual display units a new, standardized testing method for the measurement of the DVA should be achieved.
Methods: A market analysis and a feasibility analysis clarified if the display performance of modern VDUs last the demands of a reliable test. Different possibilities of the presentation of optotypes were tested experimentally, several coding languages compared.
Results: Presenting moving objects in an acceptable display performance is realizable with the Foris FG2421 (Eizo) display unit (23.5”) using the 240 Hz turbo mode. A refresh rate of 120 Hz combined with blinking backlight (240 Hz turbo mode) guarantees great motion clarity and not notable afterimages. The foundation for a standardized test procedure was developed based on the testing method for the static visual acuity. Five moving optotypes (Landolt C) are presented on a sphere for each velocity level and size for a fixed presentation time of each 2 seconds. The starting point, the direction of movement (clockwise, counterclockwise) as well as the gap of the Landolt C is randomized. The test is measuring in the range of the smooth pursuit eye movements. The test scenarios are programmed with Flash CS 6 and transformed into single video clips. The field of view is limited by the screen size, display resolution and computer performance.
Conclusions: Due to the technological progress DVA measurements could be realized using VDUs. The new standardized testing method needs to be enhanced. Further studies should determine defined velocities and sizes of the moving objects. The test should be recoded in C++ to minimize the randomization and presentation effort and to lower the required computer performance. A validation study should be run as well as new technologies (4K, HDMI 2.0) observed.
Jendrusch, Gernot; Platz, Andreas; Sickenberger, Wolfgang
02.07.2014.
@misc{Jendrusch2014,
title = {Shutter glasses as a training tool in sports vision training - changes in visual perception according to frequency and duty ratio},
author = {Gernot Jendrusch and Andreas Platz and Wolfgang Sickenberger },
url = {https://www.jenvis-research.com/ecss-2014-amsterdamshutterglassesfinal06-06-2014/},
year = {2014},
date = {2014-07-02},
urldate = {2014-07-02},
abstract = {Abstract
Introduction: Shutter glasses seem to be a tool for training visual functions in the context of sports vision training to increase movement coordination. Several studies discussed effects and non-effects of training with shutter glasses e.g. within coincidence anticipation (Smith & Mittroff, 2012; Reichow et al., 2010), motion cognition or short-time memory (Appelbaum et al., 2011 and 2012). No investigation justifies the training settings and strobe settings yet. Based on the necessity of an adequate load dosage to allow training effects, the present study intends to assess which strobe settings lead to a significant decrease of visual/perceptual performance.
Methods: 62 subjects (31m, 31f, median of age=25, median of visual acuity 1.6 (logMAR=-0.20)) took part in 13 test series to determine afferent motion perception (DTDS, Wist et al., 2000), reaction and anticipatory dynamic vision (Jendrusch & Ehrenstein, 2008), dynamic depth perception (three-rodtest according to Helmholtz) and peripheral awareness (Oculus Twinfield 2). The results with different randomized strobe rates (level 1-8) of shutter glasses (Nike Vapor Strobe) currently used in sports vision training have been compared.
Results: By increasing level (lower frequency and higher duty ratio) the afferent motion perception performance for stimulus motion duration of 280 and 420 ms decreases. Depth perception declines between level 2 and 8 respectively between level 5 and 8 according to the test velocity (7 vs. 2 mm/s). Maximum visual field decreases for blue stimuli between level 2 and 8 and for red stimuli between level 2 and 5. There is a larger decrease for red stimuli. These differences are statistically significant (p<=0.05). Reaction and anticipatory dynamic vision (timing) show no significant differences.
Conclusion: For different visual performance skills lower frequency and higher duty ratio leads to increasing perceptual stress. No discrete levels for changes in performance were found. The combination of different requirements in sports needs an adjustment of training for each skill/sport-specific demand. However, generalized (nonspecific) training with the shutter glasses lacks effect focused specificity.},
keywords = {},
pubstate = {published},
tppubtype = {presentation}
}
Abstract
Introduction: Shutter glasses seem to be a tool for training visual functions in the context of sports vision training to increase movement coordination. Several studies discussed effects and non-effects of training with shutter glasses e.g. within coincidence anticipation (Smith & Mittroff, 2012; Reichow et al., 2010), motion cognition or short-time memory (Appelbaum et al., 2011 and 2012). No investigation justifies the training settings and strobe settings yet. Based on the necessity of an adequate load dosage to allow training effects, the present study intends to assess which strobe settings lead to a significant decrease of visual/perceptual performance.
Methods: 62 subjects (31m, 31f, median of age=25, median of visual acuity 1.6 (logMAR=-0.20)) took part in 13 test series to determine afferent motion perception (DTDS, Wist et al., 2000), reaction and anticipatory dynamic vision (Jendrusch & Ehrenstein, 2008), dynamic depth perception (three-rodtest according to Helmholtz) and peripheral awareness (Oculus Twinfield 2). The results with different randomized strobe rates (level 1-8) of shutter glasses (Nike Vapor Strobe) currently used in sports vision training have been compared.
Results: By increasing level (lower frequency and higher duty ratio) the afferent motion perception performance for stimulus motion duration of 280 and 420 ms decreases. Depth perception declines between level 2 and 8 respectively between level 5 and 8 according to the test velocity (7 vs. 2 mm/s). Maximum visual field decreases for blue stimuli between level 2 and 8 and for red stimuli between level 2 and 5. There is a larger decrease for red stimuli. These differences are statistically significant (p<=0.05). Reaction and anticipatory dynamic vision (timing) show no significant differences.
Conclusion: For different visual performance skills lower frequency and higher duty ratio leads to increasing perceptual stress. No discrete levels for changes in performance were found. The combination of different requirements in sports needs an adjustment of training for each skill/sport-specific demand. However, generalized (nonspecific) training with the shutter glasses lacks effect focused specificity.
Introduction: Shutter glasses seem to be a tool for training visual functions in the context of sports vision training to increase movement coordination. Several studies discussed effects and non-effects of training with shutter glasses e.g. within coincidence anticipation (Smith & Mittroff, 2012; Reichow et al., 2010), motion cognition or short-time memory (Appelbaum et al., 2011 and 2012). No investigation justifies the training settings and strobe settings yet. Based on the necessity of an adequate load dosage to allow training effects, the present study intends to assess which strobe settings lead to a significant decrease of visual/perceptual performance.
Methods: 62 subjects (31m, 31f, median of age=25, median of visual acuity 1.6 (logMAR=-0.20)) took part in 13 test series to determine afferent motion perception (DTDS, Wist et al., 2000), reaction and anticipatory dynamic vision (Jendrusch & Ehrenstein, 2008), dynamic depth perception (three-rodtest according to Helmholtz) and peripheral awareness (Oculus Twinfield 2). The results with different randomized strobe rates (level 1-8) of shutter glasses (Nike Vapor Strobe) currently used in sports vision training have been compared.
Results: By increasing level (lower frequency and higher duty ratio) the afferent motion perception performance for stimulus motion duration of 280 and 420 ms decreases. Depth perception declines between level 2 and 8 respectively between level 5 and 8 according to the test velocity (7 vs. 2 mm/s). Maximum visual field decreases for blue stimuli between level 2 and 8 and for red stimuli between level 2 and 5. There is a larger decrease for red stimuli. These differences are statistically significant (p<=0.05). Reaction and anticipatory dynamic vision (timing) show no significant differences.
Conclusion: For different visual performance skills lower frequency and higher duty ratio leads to increasing perceptual stress. No discrete levels for changes in performance were found. The combination of different requirements in sports needs an adjustment of training for each skill/sport-specific demand. However, generalized (nonspecific) training with the shutter glasses lacks effect focused specificity.
2013
Höffel, Christopher; Oehring, Daniela; Sickenberger, Wolfgang
Experimental study to assess the influence of air draught on the lower tear meniscus height Conference
BCLA Abstract Book 2013, vol. 36, British Contact Lens Association Elsevier, 2013.
@conference{Höffel2013,
title = {Experimental study to assess the influence of air draught on the lower tear meniscus height},
author = {Christopher Höffel and Daniela Oehring and Wolfgang Sickenberger},
url = {https://www.jenvis-research.com/wp-content/uploads/2017/09/Höffel-BCLA-2013-Experimental-study-to-assess-the-influence-of-air-draught-on-the-lower-meniscus-height.pdf
http://www.contactlensjournal.com/article/S1367-0484(13)00197-5/abstract},
doi = {http://dx.doi.org/10.1016/j.clae.2013.08.083},
year = {2013},
date = {2013-12-01},
urldate = {2013-12-01},
booktitle = {BCLA Abstract Book 2013},
volume = {36},
pages = {e22},
publisher = {Elsevier},
organization = {British Contact Lens Association},
abstract = {Abstract
Purpose: The measurement of the tear meniscus height (TMH) is one of the standard tests to assess the quantity of the tear film. Aim of this study was to determine the influence of wind or air draught to the tear meniscus height.
Methods: A prospective, randomised study (n=40; 53% female, 47% male; aged (25.2+/-1.8)years) was conducted to measure central, nasal and temporal lower TMH on both eyes by means of a video-topographer (Keratograph5M, Oculus) with infrared illumination (Oculus, TF-Scan V2.2.18) under normal conditions (NC-TMH) and with wind stimulation (W-TMH), performing three consecutive measurements each. Both the nasal and temporal TMH were quantified two millimetres off the vertical pupillary centre, respectively. The air draught was generated by a wind tunnel (Sziols Inc.). The mean wind velocity was (0.8 +/- 0.2)m/s at a distance of three metres between patient and wind tunnel. Patients were exposed to air draught for one minute.
Results: The average of the central NC-TMH was determined by (0.29+/-0.13)mm, nasal by (0.27+/-0.12)mm and temporal by (0.30+/-0.13)mm. The mean value of the W-TMH was calculated central by (0.36+/-0.17)mm, nasal by (0.35+/-0.18)mm and temporal by (0.40+/-0.20)mm. There are statically significant differences between the NC-TMH and the W-TMH in all measured locations (central p=0.000, nasal p=0.000, temporal p=0.000; Wilcoxon test). The W-TMH is significantly higher than the NC-TMH (95% confidence interval of the mean: central (-0.10 to -0.05)mm, nasal (-0.10 to -0.06)mm and temporal (-0.12 to -0.07)mm).
Conclusion: The central, nasal and temporal TMHs are significantly higher under wind stimulation as under normal conditions. Based on that, it is obvious that mistakes during the assessment of the TMH may occur if the patient is exposed to air draught before. Hence, to avoid or minimise this influence, it is necessary to ask if the patient was exposed to such conditions before tear film assessment.
Additional comments: Experimental study to assess the influence of air draught on the lower tear meniscus height. },
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: The measurement of the tear meniscus height (TMH) is one of the standard tests to assess the quantity of the tear film. Aim of this study was to determine the influence of wind or air draught to the tear meniscus height.
Methods: A prospective, randomised study (n=40; 53% female, 47% male; aged (25.2+/-1.8)years) was conducted to measure central, nasal and temporal lower TMH on both eyes by means of a video-topographer (Keratograph5M, Oculus) with infrared illumination (Oculus, TF-Scan V2.2.18) under normal conditions (NC-TMH) and with wind stimulation (W-TMH), performing three consecutive measurements each. Both the nasal and temporal TMH were quantified two millimetres off the vertical pupillary centre, respectively. The air draught was generated by a wind tunnel (Sziols Inc.). The mean wind velocity was (0.8 +/- 0.2)m/s at a distance of three metres between patient and wind tunnel. Patients were exposed to air draught for one minute.
Results: The average of the central NC-TMH was determined by (0.29+/-0.13)mm, nasal by (0.27+/-0.12)mm and temporal by (0.30+/-0.13)mm. The mean value of the W-TMH was calculated central by (0.36+/-0.17)mm, nasal by (0.35+/-0.18)mm and temporal by (0.40+/-0.20)mm. There are statically significant differences between the NC-TMH and the W-TMH in all measured locations (central p=0.000, nasal p=0.000, temporal p=0.000; Wilcoxon test). The W-TMH is significantly higher than the NC-TMH (95% confidence interval of the mean: central (-0.10 to -0.05)mm, nasal (-0.10 to -0.06)mm and temporal (-0.12 to -0.07)mm).
Conclusion: The central, nasal and temporal TMHs are significantly higher under wind stimulation as under normal conditions. Based on that, it is obvious that mistakes during the assessment of the TMH may occur if the patient is exposed to air draught before. Hence, to avoid or minimise this influence, it is necessary to ask if the patient was exposed to such conditions before tear film assessment.
Additional comments: Experimental study to assess the influence of air draught on the lower tear meniscus height.
Purpose: The measurement of the tear meniscus height (TMH) is one of the standard tests to assess the quantity of the tear film. Aim of this study was to determine the influence of wind or air draught to the tear meniscus height.
Methods: A prospective, randomised study (n=40; 53% female, 47% male; aged (25.2+/-1.8)years) was conducted to measure central, nasal and temporal lower TMH on both eyes by means of a video-topographer (Keratograph5M, Oculus) with infrared illumination (Oculus, TF-Scan V2.2.18) under normal conditions (NC-TMH) and with wind stimulation (W-TMH), performing three consecutive measurements each. Both the nasal and temporal TMH were quantified two millimetres off the vertical pupillary centre, respectively. The air draught was generated by a wind tunnel (Sziols Inc.). The mean wind velocity was (0.8 +/- 0.2)m/s at a distance of three metres between patient and wind tunnel. Patients were exposed to air draught for one minute.
Results: The average of the central NC-TMH was determined by (0.29+/-0.13)mm, nasal by (0.27+/-0.12)mm and temporal by (0.30+/-0.13)mm. The mean value of the W-TMH was calculated central by (0.36+/-0.17)mm, nasal by (0.35+/-0.18)mm and temporal by (0.40+/-0.20)mm. There are statically significant differences between the NC-TMH and the W-TMH in all measured locations (central p=0.000, nasal p=0.000, temporal p=0.000; Wilcoxon test). The W-TMH is significantly higher than the NC-TMH (95% confidence interval of the mean: central (-0.10 to -0.05)mm, nasal (-0.10 to -0.06)mm and temporal (-0.12 to -0.07)mm).
Conclusion: The central, nasal and temporal TMHs are significantly higher under wind stimulation as under normal conditions. Based on that, it is obvious that mistakes during the assessment of the TMH may occur if the patient is exposed to air draught before. Hence, to avoid or minimise this influence, it is necessary to ask if the patient was exposed to such conditions before tear film assessment.
Additional comments: Experimental study to assess the influence of air draught on the lower tear meniscus height.
Wiedemann, Doreen; Sinnig, Martina; Sickenberger, Wolfgang
BCLA Abstract Book 2013, vol. 36, British Contact Lens Association Elsevier, 2013.
@conference{Wiedemann2013,
title = {Development of the tear film analysis system of a modified topographer (Keratograph5 M, Oculus) for the assessment of the lipid layer},
author = {Doreen Wiedemann and Martina Sinnig and Wolfgang Sickenberger},
url = {https://www.jenvis-research.com/wp-content/uploads/2017/09/D.Wiedemann_Poster_BCLA2013.pdf
http://www.sciencedirect.com/science/article/pii/S136704841300266X},
year = {2013},
date = {2013-12-01},
urldate = {2013-12-01},
booktitle = {BCLA Abstract Book 2013},
volume = {36},
pages = {e46},
publisher = {Elsevier},
organization = {British Contact Lens Association},
abstract = {Abstract
Purpose: To realise a new technique for the assessment of the tear-film interference pattern using the video-topographer (Keratograph5 M, Oculus) in comparison to standard tests.
Method: The illumination system of the video-topographer has been modified and a high-resolution colour camera was integrated. The typical red ring illumination was replaced and additionally white LEDs were installed on different positions. These new applications were proofed in a study (n = 41, 46% female, 54% male, age 27.2+/- 5.9 years). As reference measurements, slit lamp (SL) and the Keeler Tearscope (KT) were used. In total 369 photographs and 123 videos of the tear-film lipid layer were evaluated by three independent observers. All results were evaluated regarding to their appearance (E), interference colour (I) and quantity (K). For the inter-observer comparison between the video-topographer, the Tearscope and the slit lamp 95% confidence interval for the difference (t-Test) were calculated.
Results: The area of observation using the K5 is 9 mm. This is considerably larger than the area of the slit lamp (0.5 mm) and the Tearscope (4 mm). This enables an evaluation of the total spreading characteristic of the tear film lipid layer. There was no significant difference in the inter-observer variation of the results (95% CI of differences: observer1 (-0.4;0.3), observer2 (-0.4;0.3), observer3 (- 0.3;0.3)). A low correlation between all results was found (KT vs. K5: E r = 0.137 p = 0.408, I r = 0.371 p = 0.021, K r = 0.140 p = 0.430; SL vs. K5: E r = 0.119 p = 0.596, I r = 0.353 p = 0.045, K r = 0.071 p = 0.396).
Conclusions: Inter-observer comparisons with well established procedures show that the developed system can be an alternative for the assessment of the interference patterns. The modified video-topographer enables real-time measurements within a wider spatial range in comparison to Tearscope or slit lamp. Due to this is also possible to evaluate the inter-blink spreading characteristic of the tear film lipid layer.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: To realise a new technique for the assessment of the tear-film interference pattern using the video-topographer (Keratograph5 M, Oculus) in comparison to standard tests.
Method: The illumination system of the video-topographer has been modified and a high-resolution colour camera was integrated. The typical red ring illumination was replaced and additionally white LEDs were installed on different positions. These new applications were proofed in a study (n = 41, 46% female, 54% male, age 27.2+/- 5.9 years). As reference measurements, slit lamp (SL) and the Keeler Tearscope (KT) were used. In total 369 photographs and 123 videos of the tear-film lipid layer were evaluated by three independent observers. All results were evaluated regarding to their appearance (E), interference colour (I) and quantity (K). For the inter-observer comparison between the video-topographer, the Tearscope and the slit lamp 95% confidence interval for the difference (t-Test) were calculated.
Results: The area of observation using the K5 is 9 mm. This is considerably larger than the area of the slit lamp (0.5 mm) and the Tearscope (4 mm). This enables an evaluation of the total spreading characteristic of the tear film lipid layer. There was no significant difference in the inter-observer variation of the results (95% CI of differences: observer1 (-0.4;0.3), observer2 (-0.4;0.3), observer3 (- 0.3;0.3)). A low correlation between all results was found (KT vs. K5: E r = 0.137 p = 0.408, I r = 0.371 p = 0.021, K r = 0.140 p = 0.430; SL vs. K5: E r = 0.119 p = 0.596, I r = 0.353 p = 0.045, K r = 0.071 p = 0.396).
Conclusions: Inter-observer comparisons with well established procedures show that the developed system can be an alternative for the assessment of the interference patterns. The modified video-topographer enables real-time measurements within a wider spatial range in comparison to Tearscope or slit lamp. Due to this is also possible to evaluate the inter-blink spreading characteristic of the tear film lipid layer.
Purpose: To realise a new technique for the assessment of the tear-film interference pattern using the video-topographer (Keratograph5 M, Oculus) in comparison to standard tests.
Method: The illumination system of the video-topographer has been modified and a high-resolution colour camera was integrated. The typical red ring illumination was replaced and additionally white LEDs were installed on different positions. These new applications were proofed in a study (n = 41, 46% female, 54% male, age 27.2+/- 5.9 years). As reference measurements, slit lamp (SL) and the Keeler Tearscope (KT) were used. In total 369 photographs and 123 videos of the tear-film lipid layer were evaluated by three independent observers. All results were evaluated regarding to their appearance (E), interference colour (I) and quantity (K). For the inter-observer comparison between the video-topographer, the Tearscope and the slit lamp 95% confidence interval for the difference (t-Test) were calculated.
Results: The area of observation using the K5 is 9 mm. This is considerably larger than the area of the slit lamp (0.5 mm) and the Tearscope (4 mm). This enables an evaluation of the total spreading characteristic of the tear film lipid layer. There was no significant difference in the inter-observer variation of the results (95% CI of differences: observer1 (-0.4;0.3), observer2 (-0.4;0.3), observer3 (- 0.3;0.3)). A low correlation between all results was found (KT vs. K5: E r = 0.137 p = 0.408, I r = 0.371 p = 0.021, K r = 0.140 p = 0.430; SL vs. K5: E r = 0.119 p = 0.596, I r = 0.353 p = 0.045, K r = 0.071 p = 0.396).
Conclusions: Inter-observer comparisons with well established procedures show that the developed system can be an alternative for the assessment of the interference patterns. The modified video-topographer enables real-time measurements within a wider spatial range in comparison to Tearscope or slit lamp. Due to this is also possible to evaluate the inter-blink spreading characteristic of the tear film lipid layer.
Oehring, Daniela; Hoeffel, Christoph; Sickenberger, Wolfgang
no. 135241, American Academy of Optometry 2013.
@conference{Oehring2013,
title = {Experimental study to assess the influence of diffuse slit lamp illumination on the lower and upper tear meniscus height },
author = { Daniela Oehring and Christoph Hoeffel and Wolfgang Sickenberger },
url = {http://www.aaopt.org/experimental-study-assess-influence-diffuse-slit-lamp-illumination-lower-and-upper-tear-meniscus},
year = {2013},
date = {2013-10-25},
urldate = {2013-10-25},
number = {135241},
organization = {American Academy of Optometry},
abstract = {Abstract
Purpose:
Measurement of tear meniscus height is performed to quantify the tear film. Aim of the study was to determine the influence of diffuse illumination on the lower and upper tear meniscus height (LTMH and UTMH) of both eyes.
Methods:
A prospective, randomized study (n=38; 55% female, 45% male; aged (25.2+/-1.8)years) was conducted to measure LTMH and UTMH on both eyes by means of a video topographer (Keratograph 5M, Oculus) with infrared illumination (Oculus, TF-Scan V2.2.18) under normal conditions (NC-LTMH and NC-UTMH) and with diffuse illumination (I-LTMH and I-UTMH). Both the nasal and temporal TMH were quantified two millimeters off the central measurement. The central point was located at the vertical pupillary center. All locations were consecutively measured at three times. Each tested eye was exposed the diffuse slit lamp light (1300+/-100)lux) for ten sec in ten cm distance. The lighting device of the slit lamp was located at an angle of 25 degrees.
Results:
There are statistically significant differences between both eyes (NC-UTMH: nasal p=0.045; I-LTMH: central p=0.010 and nasal p=0.007, Wilcoxon test). In contrast there are no statistically significant differences between both eyes at the following locations (NC-LTMH: central p=0.728, nasal p=0.898, temporal p=0.438; NC-UTMH: central p=0.124, temporal p=0.635; I-LTMH: temporal p=0.392; I-UTMH: central p=0.451, nasal p=0.380, temporal p=0.922, Wilcoxon test). The nasal NC-UTMH-OS is higher than nasal NC-UTMH-OD (95% confidence interval of the mean (95%CI): (-0.04 to 0.00)mm). Both the central I-LTMH-OD and nasal I-LTMH-OD are higher than central I-LTMH-OS and nasal I-LTMH-OS (95%CI: central (0.01 to 0.06)mm and nasal (0.02 to 0.07)mm).
Conclusions:
The nasal NC-UTMH as well as the central and nasal I-LTMH are significantly different in both eyes. This indicates that the assessment of the tear film should be performed on both eyes because physiological differences of the TMH may exist. In addition, the determination of the temporal tear meniscus height prevents inaccuracies. It is expected that especially the anatomy of the lower eye lid influences the TMH.
Additional comments:
This study was performed as Bachelor of Science thesis at the Ernst-Abbe University of Applied Sciences Jena, Germany.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose:
Measurement of tear meniscus height is performed to quantify the tear film. Aim of the study was to determine the influence of diffuse illumination on the lower and upper tear meniscus height (LTMH and UTMH) of both eyes.
Methods:
A prospective, randomized study (n=38; 55% female, 45% male; aged (25.2+/-1.8)years) was conducted to measure LTMH and UTMH on both eyes by means of a video topographer (Keratograph 5M, Oculus) with infrared illumination (Oculus, TF-Scan V2.2.18) under normal conditions (NC-LTMH and NC-UTMH) and with diffuse illumination (I-LTMH and I-UTMH). Both the nasal and temporal TMH were quantified two millimeters off the central measurement. The central point was located at the vertical pupillary center. All locations were consecutively measured at three times. Each tested eye was exposed the diffuse slit lamp light (1300+/-100)lux) for ten sec in ten cm distance. The lighting device of the slit lamp was located at an angle of 25 degrees.
Results:
There are statistically significant differences between both eyes (NC-UTMH: nasal p=0.045; I-LTMH: central p=0.010 and nasal p=0.007, Wilcoxon test). In contrast there are no statistically significant differences between both eyes at the following locations (NC-LTMH: central p=0.728, nasal p=0.898, temporal p=0.438; NC-UTMH: central p=0.124, temporal p=0.635; I-LTMH: temporal p=0.392; I-UTMH: central p=0.451, nasal p=0.380, temporal p=0.922, Wilcoxon test). The nasal NC-UTMH-OS is higher than nasal NC-UTMH-OD (95% confidence interval of the mean (95%CI): (-0.04 to 0.00)mm). Both the central I-LTMH-OD and nasal I-LTMH-OD are higher than central I-LTMH-OS and nasal I-LTMH-OS (95%CI: central (0.01 to 0.06)mm and nasal (0.02 to 0.07)mm).
Conclusions:
The nasal NC-UTMH as well as the central and nasal I-LTMH are significantly different in both eyes. This indicates that the assessment of the tear film should be performed on both eyes because physiological differences of the TMH may exist. In addition, the determination of the temporal tear meniscus height prevents inaccuracies. It is expected that especially the anatomy of the lower eye lid influences the TMH.
Additional comments:
This study was performed as Bachelor of Science thesis at the Ernst-Abbe University of Applied Sciences Jena, Germany.
Purpose:
Measurement of tear meniscus height is performed to quantify the tear film. Aim of the study was to determine the influence of diffuse illumination on the lower and upper tear meniscus height (LTMH and UTMH) of both eyes.
Methods:
A prospective, randomized study (n=38; 55% female, 45% male; aged (25.2+/-1.8)years) was conducted to measure LTMH and UTMH on both eyes by means of a video topographer (Keratograph 5M, Oculus) with infrared illumination (Oculus, TF-Scan V2.2.18) under normal conditions (NC-LTMH and NC-UTMH) and with diffuse illumination (I-LTMH and I-UTMH). Both the nasal and temporal TMH were quantified two millimeters off the central measurement. The central point was located at the vertical pupillary center. All locations were consecutively measured at three times. Each tested eye was exposed the diffuse slit lamp light (1300+/-100)lux) for ten sec in ten cm distance. The lighting device of the slit lamp was located at an angle of 25 degrees.
Results:
There are statistically significant differences between both eyes (NC-UTMH: nasal p=0.045; I-LTMH: central p=0.010 and nasal p=0.007, Wilcoxon test). In contrast there are no statistically significant differences between both eyes at the following locations (NC-LTMH: central p=0.728, nasal p=0.898, temporal p=0.438; NC-UTMH: central p=0.124, temporal p=0.635; I-LTMH: temporal p=0.392; I-UTMH: central p=0.451, nasal p=0.380, temporal p=0.922, Wilcoxon test). The nasal NC-UTMH-OS is higher than nasal NC-UTMH-OD (95% confidence interval of the mean (95%CI): (-0.04 to 0.00)mm). Both the central I-LTMH-OD and nasal I-LTMH-OD are higher than central I-LTMH-OS and nasal I-LTMH-OS (95%CI: central (0.01 to 0.06)mm and nasal (0.02 to 0.07)mm).
Conclusions:
The nasal NC-UTMH as well as the central and nasal I-LTMH are significantly different in both eyes. This indicates that the assessment of the tear film should be performed on both eyes because physiological differences of the TMH may exist. In addition, the determination of the temporal tear meniscus height prevents inaccuracies. It is expected that especially the anatomy of the lower eye lid influences the TMH.
Additional comments:
This study was performed as Bachelor of Science thesis at the Ernst-Abbe University of Applied Sciences Jena, Germany.
Marx, Sebastian; Sinnig, Martina; Sickenberger, Wolfgang
no. 130287, American Academy of Optometry 2013.
@conference{Marx2013,
title = {Assessment of the wettability of different silicone hydrogel contact lenses using a novel in vitro method},
author = {Sebastian Marx and Martina Sinnig and Wolfgang Sickenberger},
url = {https://www.jenvis-research.com/wp-content/uploads/2017/09/Marx-Sinnig-WS-Assessment-of-the-wettability-of-different-silicone-hydrogel-contact-lenses-using-a-novel-in-vitro-method.pdf
http://www.aaopt.org/assessment-wettability-different-silicone-hydrogel-contact-lenses-using-novel-vitro-method},
year = {2013},
date = {2013-10-23},
urldate = {2013-10-23},
number = {130287},
organization = {American Academy of Optometry},
abstract = {Abstract
Purpose: The aim of the study was to determine differences between the surface wettability of various lens/solution combinations in terms of the drying-up time measured in vitro using a modified corneal topographer (Non-Invasive Keratograph – Drying-Up Time (NIK-DUT)).
Methods: Five market-leading silicone hydrogel (SiHy) contact lenses were tested out of the blister solution or after a washing procedure and subsequent soak in renu fresh® MPS, OPTI-FREE® PureMoist® MPDS (OFPM) or Bausch and Lomb Sensitive Eyes saline (control). The NIK-DUT was measured ten times for every combination by evaluating the reflected placido-ring image objectively. The focus was on the measurement of the NIK-DUT value derived when 25% of the entire measurement segments showed dry-up during the measuring time (NIK-DUT_S25). Based on an asymptotic, normally distributed mean value an analysis of variance (ANOVA, alpha=0.05) and subsequently a 2-tailed t-test was conducted to determine inter-group comparisons.
Results: The average NIK-DUT_S25 value among the 5 test lenses (Balafilcon A, Lotrafilcon B with Aqua Technology, Lotrafilcon A, Comfilcon A and Senolfilcon A) in combination with saline solution was 124.8±3.5s. The same lenses showed average increases of 8.7% out of the blister solution (135.6±11.6s), 7.0% with renu fresh (133.6±23.6s), and 22.9% with OFPM (153.4±23.3s). With saline as reference the results of the t-test are p=0,05 to OFPM; 0,11 to blister solution and 0,45 to renu fresh.
Conclusion: There are relevant differences between lens packaging and care solution regarding the wettability of the SiHy lenses. Increasing lens wettability through use of a lens care solution with a wetting agent designed to interact with silicone material may have a positive impact on the patient’s lens wearing experience.
Additional comments: The study was financially supported by Alcon Research Ltd.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: The aim of the study was to determine differences between the surface wettability of various lens/solution combinations in terms of the drying-up time measured in vitro using a modified corneal topographer (Non-Invasive Keratograph – Drying-Up Time (NIK-DUT)).
Methods: Five market-leading silicone hydrogel (SiHy) contact lenses were tested out of the blister solution or after a washing procedure and subsequent soak in renu fresh® MPS, OPTI-FREE® PureMoist® MPDS (OFPM) or Bausch and Lomb Sensitive Eyes saline (control). The NIK-DUT was measured ten times for every combination by evaluating the reflected placido-ring image objectively. The focus was on the measurement of the NIK-DUT value derived when 25% of the entire measurement segments showed dry-up during the measuring time (NIK-DUT_S25). Based on an asymptotic, normally distributed mean value an analysis of variance (ANOVA, alpha=0.05) and subsequently a 2-tailed t-test was conducted to determine inter-group comparisons.
Results: The average NIK-DUT_S25 value among the 5 test lenses (Balafilcon A, Lotrafilcon B with Aqua Technology, Lotrafilcon A, Comfilcon A and Senolfilcon A) in combination with saline solution was 124.8±3.5s. The same lenses showed average increases of 8.7% out of the blister solution (135.6±11.6s), 7.0% with renu fresh (133.6±23.6s), and 22.9% with OFPM (153.4±23.3s). With saline as reference the results of the t-test are p=0,05 to OFPM; 0,11 to blister solution and 0,45 to renu fresh.
Conclusion: There are relevant differences between lens packaging and care solution regarding the wettability of the SiHy lenses. Increasing lens wettability through use of a lens care solution with a wetting agent designed to interact with silicone material may have a positive impact on the patient’s lens wearing experience.
Additional comments: The study was financially supported by Alcon Research Ltd.
Purpose: The aim of the study was to determine differences between the surface wettability of various lens/solution combinations in terms of the drying-up time measured in vitro using a modified corneal topographer (Non-Invasive Keratograph – Drying-Up Time (NIK-DUT)).
Methods: Five market-leading silicone hydrogel (SiHy) contact lenses were tested out of the blister solution or after a washing procedure and subsequent soak in renu fresh® MPS, OPTI-FREE® PureMoist® MPDS (OFPM) or Bausch and Lomb Sensitive Eyes saline (control). The NIK-DUT was measured ten times for every combination by evaluating the reflected placido-ring image objectively. The focus was on the measurement of the NIK-DUT value derived when 25% of the entire measurement segments showed dry-up during the measuring time (NIK-DUT_S25). Based on an asymptotic, normally distributed mean value an analysis of variance (ANOVA, alpha=0.05) and subsequently a 2-tailed t-test was conducted to determine inter-group comparisons.
Results: The average NIK-DUT_S25 value among the 5 test lenses (Balafilcon A, Lotrafilcon B with Aqua Technology, Lotrafilcon A, Comfilcon A and Senolfilcon A) in combination with saline solution was 124.8±3.5s. The same lenses showed average increases of 8.7% out of the blister solution (135.6±11.6s), 7.0% with renu fresh (133.6±23.6s), and 22.9% with OFPM (153.4±23.3s). With saline as reference the results of the t-test are p=0,05 to OFPM; 0,11 to blister solution and 0,45 to renu fresh.
Conclusion: There are relevant differences between lens packaging and care solution regarding the wettability of the SiHy lenses. Increasing lens wettability through use of a lens care solution with a wetting agent designed to interact with silicone material may have a positive impact on the patient’s lens wearing experience.
Additional comments: The study was financially supported by Alcon Research Ltd.
Schubert, Sebastian; Rehnert, Mario; Sickenberger, Wolfgang
no. 135124, American Academy of Optometry 2013.
@conference{Schubert2013,
title = {Prospective study on success rates of fitting simultaneous multifocal contact lenses in relation to physiological circumstances},
author = {Sebastian Schubert and Mario Rehnert and Wolfgang Sickenberger},
url = {https://www.jenvis-research.com/wp-content/uploads/2017/09/AAO-2013-SS-Prospective-study-on-success-rates-of-fitting-simultanous-multifocal-contact-lenses-in-relation-to-physiological-circumstances.pdf
http://www.aaopt.org/prospective-study-success-rates-fitting-simultaneous-multifocal-contact-lenses-relation},
year = {2013},
date = {2013-10-23},
urldate = {2013-10-23},
number = {135124},
organization = {American Academy of Optometry},
abstract = {Abstract
Purpose: The Purpose of this study was to prove a significant influence of the parameters amplitude of pupillary light reflex, decentration of contact lenses and anterior chamber depth on the success of fitting simultaneous multifocal contact lenses with “near-in-centre” design.
Methods: All variables were measured at n=20 successful users (54.9 ± 6.3 years). The anterior chamber depth were determined by a Scheimpflug-camera and the amplitude of pupillary light reflex on fotopic and scotopic conditions were gauged by an integrated pupillograph. The decentration of contact lenses were assessed on slit lamp pictures by using a virtual measuring device. Additionally, the subjects had to evaluate the visual performance for both far and near vision, and in general.
Results: The contact lens decentration was OD -0.14 ± 0.23mm, OS +0.03 ± 0.19mm in horizontal direction and -0.09 ± 0.27mm in vertical orientation on both eyes. Comparing to related studies the contact lens decentration is significantly different (p<0,001). Furthermore, an anterior chamber depth of 2.67 ± 0,35mm and an amplitude of pupillary light reflex of 1.96 ± 0.49mm were measured. The evaluation of the visual performance showed a significant correlation of anterior chamber depth for far vision (r= -0,47 ; p= 0,037)
Conclusion: The amplitude of pupillary light reflex and anterior chamber depth may have a highly potential influence on a successful fitting of multifocal contact lenses. Moreover, the amplitude of pupillary light reflex up to 1.5mm can be beneficial.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: The Purpose of this study was to prove a significant influence of the parameters amplitude of pupillary light reflex, decentration of contact lenses and anterior chamber depth on the success of fitting simultaneous multifocal contact lenses with “near-in-centre” design.
Methods: All variables were measured at n=20 successful users (54.9 ± 6.3 years). The anterior chamber depth were determined by a Scheimpflug-camera and the amplitude of pupillary light reflex on fotopic and scotopic conditions were gauged by an integrated pupillograph. The decentration of contact lenses were assessed on slit lamp pictures by using a virtual measuring device. Additionally, the subjects had to evaluate the visual performance for both far and near vision, and in general.
Results: The contact lens decentration was OD -0.14 ± 0.23mm, OS +0.03 ± 0.19mm in horizontal direction and -0.09 ± 0.27mm in vertical orientation on both eyes. Comparing to related studies the contact lens decentration is significantly different (p<0,001). Furthermore, an anterior chamber depth of 2.67 ± 0,35mm and an amplitude of pupillary light reflex of 1.96 ± 0.49mm were measured. The evaluation of the visual performance showed a significant correlation of anterior chamber depth for far vision (r= -0,47 ; p= 0,037)
Conclusion: The amplitude of pupillary light reflex and anterior chamber depth may have a highly potential influence on a successful fitting of multifocal contact lenses. Moreover, the amplitude of pupillary light reflex up to 1.5mm can be beneficial.
Purpose: The Purpose of this study was to prove a significant influence of the parameters amplitude of pupillary light reflex, decentration of contact lenses and anterior chamber depth on the success of fitting simultaneous multifocal contact lenses with “near-in-centre” design.
Methods: All variables were measured at n=20 successful users (54.9 ± 6.3 years). The anterior chamber depth were determined by a Scheimpflug-camera and the amplitude of pupillary light reflex on fotopic and scotopic conditions were gauged by an integrated pupillograph. The decentration of contact lenses were assessed on slit lamp pictures by using a virtual measuring device. Additionally, the subjects had to evaluate the visual performance for both far and near vision, and in general.
Results: The contact lens decentration was OD -0.14 ± 0.23mm, OS +0.03 ± 0.19mm in horizontal direction and -0.09 ± 0.27mm in vertical orientation on both eyes. Comparing to related studies the contact lens decentration is significantly different (p<0,001). Furthermore, an anterior chamber depth of 2.67 ± 0,35mm and an amplitude of pupillary light reflex of 1.96 ± 0.49mm were measured. The evaluation of the visual performance showed a significant correlation of anterior chamber depth for far vision (r= -0,47 ; p= 0,037)
Conclusion: The amplitude of pupillary light reflex and anterior chamber depth may have a highly potential influence on a successful fitting of multifocal contact lenses. Moreover, the amplitude of pupillary light reflex up to 1.5mm can be beneficial.
2012
Wittekind, Julia; Marx, Sebastian; Sickenberger, Wolfgang
BCLA Abstract Book 2012, vol. 35, 2012.
@conference{Wittekind2012,
title = {Study determining the reproducibility of the non-invasive break- up time by corneal topographer (NIK-BUT) method for infrared, red and white illumination},
author = {Julia Wittekind and Sebastian Marx and Wolfgang Sickenberger},
url = {https://www.jenvis-research.com/wp-content/uploads/2017/09/Poster_BCLA_2012_JuliaWittekind.pdf
http://www.contactlensjournal.com/article/S1367-0484(12)00203-2/abstract},
doi = {http://dx.doi.org/10.1016/j.clae.2012.08.101},
year = {2012},
date = {2012-12-01},
urldate = {2012-12-01},
booktitle = {BCLA Abstract Book 2012},
volume = {35},
pages = {e32},
abstract = {Abstract
Purpose: The aim of the study was to measure the reproducibility of the non-invasive break-up time (NIK-BUT) method using three different illumination colours.
Methods: 48 subjects were enrolled (mean age 34,8 ± 15,2 years; 50% female, 50% male). The reproducibility of NIK-BUT (OCULUS Keratograph 4, Version: 1.76b53rH) was tested on three consecutive days at the same day time. Infrared, red and white illumination was examined in a randomized order. A comparison of the first break-up (NIKf-BUT) and the average of all affected areas (NIKav-BUT) was made.
Results: The normal distribution (n=48, Shapiro-Wilk-test) of the results was yielded for the NIKav-BUT with red illumination. The other results of the examination are not normally distributed. Results show that there is no statistical difference regardless of the illumination, which was used on three consecutive days (infrared illumination without a glare ring: NIKfBUT p=0,09, NIKav-BUT p=0,243; white illumination with a glare ring: NIKf-BUT p=0,558, NIKav-BUT p=0,864; red illumination: NIKf-BUT p=0,763, NIKav-BUT p=0,781).
Conclusion: The results of the non-invasive keratographic break-up time on three successive days were equal.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: The aim of the study was to measure the reproducibility of the non-invasive break-up time (NIK-BUT) method using three different illumination colours.
Methods: 48 subjects were enrolled (mean age 34,8 ± 15,2 years; 50% female, 50% male). The reproducibility of NIK-BUT (OCULUS Keratograph 4, Version: 1.76b53rH) was tested on three consecutive days at the same day time. Infrared, red and white illumination was examined in a randomized order. A comparison of the first break-up (NIKf-BUT) and the average of all affected areas (NIKav-BUT) was made.
Results: The normal distribution (n=48, Shapiro-Wilk-test) of the results was yielded for the NIKav-BUT with red illumination. The other results of the examination are not normally distributed. Results show that there is no statistical difference regardless of the illumination, which was used on three consecutive days (infrared illumination without a glare ring: NIKfBUT p=0,09, NIKav-BUT p=0,243; white illumination with a glare ring: NIKf-BUT p=0,558, NIKav-BUT p=0,864; red illumination: NIKf-BUT p=0,763, NIKav-BUT p=0,781).
Conclusion: The results of the non-invasive keratographic break-up time on three successive days were equal.
Purpose: The aim of the study was to measure the reproducibility of the non-invasive break-up time (NIK-BUT) method using three different illumination colours.
Methods: 48 subjects were enrolled (mean age 34,8 ± 15,2 years; 50% female, 50% male). The reproducibility of NIK-BUT (OCULUS Keratograph 4, Version: 1.76b53rH) was tested on three consecutive days at the same day time. Infrared, red and white illumination was examined in a randomized order. A comparison of the first break-up (NIKf-BUT) and the average of all affected areas (NIKav-BUT) was made.
Results: The normal distribution (n=48, Shapiro-Wilk-test) of the results was yielded for the NIKav-BUT with red illumination. The other results of the examination are not normally distributed. Results show that there is no statistical difference regardless of the illumination, which was used on three consecutive days (infrared illumination without a glare ring: NIKfBUT p=0,09, NIKav-BUT p=0,243; white illumination with a glare ring: NIKf-BUT p=0,558, NIKav-BUT p=0,864; red illumination: NIKf-BUT p=0,763, NIKav-BUT p=0,781).
Conclusion: The results of the non-invasive keratographic break-up time on three successive days were equal.
Kuntz, Jörg; Michel, Martina; Sickenberger, Wolfgang
Novel method to evaluate the tear flow velocity by using a corneal topographer Conference
BCLA Abstract Book 2012, vol. 35, 2012.
@conference{Kuntz2012,
title = {Novel method to evaluate the tear flow velocity by using a corneal topographer},
author = {Jörg Kuntz and Martina Michel and Wolfgang Sickenberger},
url = {https://www.jenvis-research.com/wp-content/uploads/2016/07/Poster_Joerg_Kuntz.pdf
http://www.sciencedirect.com/science/article/pii/S1367048412002020
http://www.contactlensjournal.com/article/S1367-0484(12)00202-0/abstract},
doi = {http://dx.doi.org/10.1016/j.clae.2012.08.100},
year = {2012},
date = {2012-12-01},
urldate = {2012-12-01},
booktitle = {BCLA Abstract Book 2012},
volume = {35},
pages = {e32},
abstract = {Abstract
Purpose: Aim of the study was to develop and test a novel method to evaluate the tear flow rate with a corneal topographer. The results were used in preparation for a subsequent objective analysis to classify tear film quality.
Methods: An appropriate application of the corneal topographer was developed to evaluate tear flow behavior of tear film by means of particles contained therein. 34 subjects (mean age 37.1± 19.1; male 38% female 62%) participated in this pilot study. A slitlamp observation was used for reference. To classify the flow behavior, established methods for tear film analysis were used (TMH; Interference; PRT). Particles were tracked manually to establish a base for the later development of automatic tracking.
Results. The median of the tear flow with the topographer was 1.19 mm/s (mean= 1.10± 0,39 mm/s) after 1 second, the median of the slitlamp was 1.15 mm/s (mean= 1.24± 0.47 mm/s). A normal distribution (Shapiro-Wilk-Test) was found for the new method (p=0.365) and the reference (p=0.216). No significant difference between the methods (p=0.113; T-Test) was found. A correlation between them (p=0.044) became obvious. However no correlation between these velocities and the established methods (TMH; Interference; PRT) was proved.
Conclusion: The modified illumination of the topographer allows a subjective assessment of the tear flow and its comparison with the reference. The objective analysis is due to this pilot study
limited. To develop a classification of this method, further studies are required.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: Aim of the study was to develop and test a novel method to evaluate the tear flow rate with a corneal topographer. The results were used in preparation for a subsequent objective analysis to classify tear film quality.
Methods: An appropriate application of the corneal topographer was developed to evaluate tear flow behavior of tear film by means of particles contained therein. 34 subjects (mean age 37.1± 19.1; male 38% female 62%) participated in this pilot study. A slitlamp observation was used for reference. To classify the flow behavior, established methods for tear film analysis were used (TMH; Interference; PRT). Particles were tracked manually to establish a base for the later development of automatic tracking.
Results. The median of the tear flow with the topographer was 1.19 mm/s (mean= 1.10± 0,39 mm/s) after 1 second, the median of the slitlamp was 1.15 mm/s (mean= 1.24± 0.47 mm/s). A normal distribution (Shapiro-Wilk-Test) was found for the new method (p=0.365) and the reference (p=0.216). No significant difference between the methods (p=0.113; T-Test) was found. A correlation between them (p=0.044) became obvious. However no correlation between these velocities and the established methods (TMH; Interference; PRT) was proved.
Conclusion: The modified illumination of the topographer allows a subjective assessment of the tear flow and its comparison with the reference. The objective analysis is due to this pilot study
limited. To develop a classification of this method, further studies are required.
Purpose: Aim of the study was to develop and test a novel method to evaluate the tear flow rate with a corneal topographer. The results were used in preparation for a subsequent objective analysis to classify tear film quality.
Methods: An appropriate application of the corneal topographer was developed to evaluate tear flow behavior of tear film by means of particles contained therein. 34 subjects (mean age 37.1± 19.1; male 38% female 62%) participated in this pilot study. A slitlamp observation was used for reference. To classify the flow behavior, established methods for tear film analysis were used (TMH; Interference; PRT). Particles were tracked manually to establish a base for the later development of automatic tracking.
Results. The median of the tear flow with the topographer was 1.19 mm/s (mean= 1.10± 0,39 mm/s) after 1 second, the median of the slitlamp was 1.15 mm/s (mean= 1.24± 0.47 mm/s). A normal distribution (Shapiro-Wilk-Test) was found for the new method (p=0.365) and the reference (p=0.216). No significant difference between the methods (p=0.113; T-Test) was found. A correlation between them (p=0.044) became obvious. However no correlation between these velocities and the established methods (TMH; Interference; PRT) was proved.
Conclusion: The modified illumination of the topographer allows a subjective assessment of the tear flow and its comparison with the reference. The objective analysis is due to this pilot study
limited. To develop a classification of this method, further studies are required.
Jerchel, Nicole; Sickenberger, Wolfgang; Schulze, Marc M.
Objective classification and documentation of bulbar redness using a corneal topographer Conference
BCLA Abstract Book 2012, vol. 35, Elsevier, 2012.
@conference{Jerchel2012,
title = {Objective classification and documentation of bulbar redness using a corneal topographer},
author = {Nicole Jerchel and Wolfgang Sickenberger and Marc M. Schulze},
url = {http://www.sciencedirect.com/science/article/pii/S1367048412001609
http://www.contactlensjournal.com/article/S1367-0484(12)00160-9/abstract},
doi = {http://dx.doi.org/10.1016/j.clae.2012.08.058},
year = {2012},
date = {2012-12-01},
urldate = {2012-12-01},
booktitle = {BCLA Abstract Book 2012},
volume = {35},
pages = {e18},
publisher = {Elsevier},
abstract = {Abstract
Purpose: To develop a novel automated method for objective classification and documentation of bulbar redness.
Method: The Oculus Keratograph, a corneal topographer was modified regarding illumination, camera and region of interest. 50 eyes of 25 subjects were imaged using the topographer and a slit lamp. 28 digital photographs of bulbar conjunctiva taken with the topographer and 10 images of the same eyes taken during the slit lamp examination were chosen. These 38 images were graded by 18 independent observers on a 100-point sliding scale through a world wide web-based survey. In addition, 25 of the 28 images taken with the topographer were digitally analysed to extract the following objective variables: proportion of area occupied by vessels (va), number of vessels (nv), proportion of area occupied by thin vessels (tva).
Results: The comparison of means for the subjective grading of both imaging methods showed significant differences in six of ten cases. (Wilcoxon test and t-test: p < 0.035). In general, subjective gradings of the slit lamp images showed a higher standard deviation than for the topographer images. There were significant associations between subjective grading estimates and all of the objective variables, with r(va) = 0.79, r(nv) = 0.843 and r(tva) = 0.811 (Spearman-Rank test; all p < 0.001).
Conclusions: Using a modified corneal topographer for imaging conjunctival redness is a novel approach that allows a more uniform and constant illumination compared to other imaging techniques. The objective quantification of redness was highly correlated to subjective grading, and might provide a better alternative in daily practice because it reduces the inherent variability of subjective assessments.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: To develop a novel automated method for objective classification and documentation of bulbar redness.
Method: The Oculus Keratograph, a corneal topographer was modified regarding illumination, camera and region of interest. 50 eyes of 25 subjects were imaged using the topographer and a slit lamp. 28 digital photographs of bulbar conjunctiva taken with the topographer and 10 images of the same eyes taken during the slit lamp examination were chosen. These 38 images were graded by 18 independent observers on a 100-point sliding scale through a world wide web-based survey. In addition, 25 of the 28 images taken with the topographer were digitally analysed to extract the following objective variables: proportion of area occupied by vessels (va), number of vessels (nv), proportion of area occupied by thin vessels (tva).
Results: The comparison of means for the subjective grading of both imaging methods showed significant differences in six of ten cases. (Wilcoxon test and t-test: p < 0.035). In general, subjective gradings of the slit lamp images showed a higher standard deviation than for the topographer images. There were significant associations between subjective grading estimates and all of the objective variables, with r(va) = 0.79, r(nv) = 0.843 and r(tva) = 0.811 (Spearman-Rank test; all p < 0.001).
Conclusions: Using a modified corneal topographer for imaging conjunctival redness is a novel approach that allows a more uniform and constant illumination compared to other imaging techniques. The objective quantification of redness was highly correlated to subjective grading, and might provide a better alternative in daily practice because it reduces the inherent variability of subjective assessments.
Purpose: To develop a novel automated method for objective classification and documentation of bulbar redness.
Method: The Oculus Keratograph, a corneal topographer was modified regarding illumination, camera and region of interest. 50 eyes of 25 subjects were imaged using the topographer and a slit lamp. 28 digital photographs of bulbar conjunctiva taken with the topographer and 10 images of the same eyes taken during the slit lamp examination were chosen. These 38 images were graded by 18 independent observers on a 100-point sliding scale through a world wide web-based survey. In addition, 25 of the 28 images taken with the topographer were digitally analysed to extract the following objective variables: proportion of area occupied by vessels (va), number of vessels (nv), proportion of area occupied by thin vessels (tva).
Results: The comparison of means for the subjective grading of both imaging methods showed significant differences in six of ten cases. (Wilcoxon test and t-test: p < 0.035). In general, subjective gradings of the slit lamp images showed a higher standard deviation than for the topographer images. There were significant associations between subjective grading estimates and all of the objective variables, with r(va) = 0.79, r(nv) = 0.843 and r(tva) = 0.811 (Spearman-Rank test; all p < 0.001).
Conclusions: Using a modified corneal topographer for imaging conjunctival redness is a novel approach that allows a more uniform and constant illumination compared to other imaging techniques. The objective quantification of redness was highly correlated to subjective grading, and might provide a better alternative in daily practice because it reduces the inherent variability of subjective assessments.
Sickenberger, Wolfgang; Oehring, Daniela
Validation of a novel morphing software to classify different slit lamp findings Conference
BCLA Abstract Book 2012, vol. 35, Elsevier, 2012.
@conference{Sickenberger2012,
title = {Validation of a novel morphing software to classify different slit lamp findings},
author = {Wolfgang Sickenberger and Daniela Oehring},
url = {https://www.jenvis-research.com/wp-content/uploads/2017/09/Poster_BCLA_2012_DO_final-1.pdf
http://www.contactlensjournal.com/article/S1367-0484(12)00167-1/abstract},
doi = {http://dx.doi.org/10.1016/j.clae.2012.08.065},
year = {2012},
date = {2012-12-01},
urldate = {2012-12-01},
booktitle = {BCLA Abstract Book 2012},
volume = {35},
pages = {e20-21},
publisher = {Elsevier},
abstract = {Abstract
Purpose: To validate a novel morphing software for classification of slit lamp findings and to then compare grades obtained with the new morphing software and with a printed grading scale.
Method: To develop the morphing software, 101 images each of eight different slit lamp findings, showing increasing severity from normal to severe, were provided and converted into a video clip; the image number was coded into running time. The study was divided in three phases. First, 67 participants (22 students, 45 professionals) were asked to evaluate five actual-scale images using the JenVis printed grading scale. Second, the participants were asked to identify the limits of the morphing software grades (using the video position for conversion to grades), and to then grade the same actual-scale images now using the morphing software.
Results: The limits of grades were on average: Grade 1 (17 ± 8), 2 (39 ± 8), 3 (62 ± 7) and 4 (81 ± 8). All the findings were graded similarly irrespective of whether the grading scales or the morphing software was used (t-test paired samples; all p > 0.667), with the exception of corneal neovascularization for which grades were higher when using the grading scale (t-test paired sample; p = 0.012). Both subgroups had no significant deviation between grade of actual-scale image and grading by participant (p = 0.089 t-test unpaired samples).
Conclusions: Limits of grades of findings for morphing software could be determined and were integrated in the software. An exact grading is possible by use of grading scale and morphing software},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Abstract
Purpose: To validate a novel morphing software for classification of slit lamp findings and to then compare grades obtained with the new morphing software and with a printed grading scale.
Method: To develop the morphing software, 101 images each of eight different slit lamp findings, showing increasing severity from normal to severe, were provided and converted into a video clip; the image number was coded into running time. The study was divided in three phases. First, 67 participants (22 students, 45 professionals) were asked to evaluate five actual-scale images using the JenVis printed grading scale. Second, the participants were asked to identify the limits of the morphing software grades (using the video position for conversion to grades), and to then grade the same actual-scale images now using the morphing software.
Results: The limits of grades were on average: Grade 1 (17 ± 8), 2 (39 ± 8), 3 (62 ± 7) and 4 (81 ± 8). All the findings were graded similarly irrespective of whether the grading scales or the morphing software was used (t-test paired samples; all p > 0.667), with the exception of corneal neovascularization for which grades were higher when using the grading scale (t-test paired sample; p = 0.012). Both subgroups had no significant deviation between grade of actual-scale image and grading by participant (p = 0.089 t-test unpaired samples).
Conclusions: Limits of grades of findings for morphing software could be determined and were integrated in the software. An exact grading is possible by use of grading scale and morphing software
Purpose: To validate a novel morphing software for classification of slit lamp findings and to then compare grades obtained with the new morphing software and with a printed grading scale.
Method: To develop the morphing software, 101 images each of eight different slit lamp findings, showing increasing severity from normal to severe, were provided and converted into a video clip; the image number was coded into running time. The study was divided in three phases. First, 67 participants (22 students, 45 professionals) were asked to evaluate five actual-scale images using the JenVis printed grading scale. Second, the participants were asked to identify the limits of the morphing software grades (using the video position for conversion to grades), and to then grade the same actual-scale images now using the morphing software.
Results: The limits of grades were on average: Grade 1 (17 ± 8), 2 (39 ± 8), 3 (62 ± 7) and 4 (81 ± 8). All the findings were graded similarly irrespective of whether the grading scales or the morphing software was used (t-test paired samples; all p > 0.667), with the exception of corneal neovascularization for which grades were higher when using the grading scale (t-test paired sample; p = 0.012). Both subgroups had no significant deviation between grade of actual-scale image and grading by participant (p = 0.089 t-test unpaired samples).
Conclusions: Limits of grades of findings for morphing software could be determined and were integrated in the software. An exact grading is possible by use of grading scale and morphing software